RO98111B1 - Procedeu pentru prepararea unui hidrat cristalin al acidului 7beta-[(z)-2-(2-aminotiazol-4-il)-4-carboxibutil-2-enoilamino]-3-cefem-4-carboxilic - Google Patents
Procedeu pentru prepararea unui hidrat cristalin al acidului 7beta-[(z)-2-(2-aminotiazol-4-il)-4-carboxibutil-2-enoilamino]-3-cefem-4-carboxilicInfo
- Publication number
- RO98111B1 RO98111B1 RO128826A RO12882687A RO98111B1 RO 98111 B1 RO98111 B1 RO 98111B1 RO 128826 A RO128826 A RO 128826A RO 12882687 A RO12882687 A RO 12882687A RO 98111 B1 RO98111 B1 RO 98111B1
- Authority
- RO
- Romania
- Prior art keywords
- acid
- enoylamino
- beta
- carboxylic acid
- carboxybutyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- -1 2-aminothiazol-4-yl Chemical group 0.000 abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 abstract 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- AVVAPFZUJJISAX-UHFFFAOYSA-N azanium N,N-diethylethanamine hydroxide Chemical compound C(C)N(CC)CC.[OH-].[NH4+] AVVAPFZUJJISAX-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011736 potassium bicarbonate Substances 0.000 abstract 1
- 235000015497 potassium bicarbonate Nutrition 0.000 abstract 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 235000011181 potassium carbonates Nutrition 0.000 abstract 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 abstract 1
- 235000011118 potassium hydroxide Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unui hidrat cristalin al acidului 7-beta-[(Z)-2-(2-aminotiazol-4-il)-4-carboxibutil-2-enoil-amino]-3-cefem-4-carboxilic, caracterizat prin aceea ca, în scopul realizarii unor cristale cu un continutde 7...14% apa de cristalizare, se dizolva 7-beta-[(Z)-2-(2-aminotiazol-4-il)-4-carboxibut-2-enoilamino]-3-cefem-4-carboxilic, pâna la o concentratie de 2...15% într-o solutie apoasa de acid, ales dintre acid clorhidric, acidul fumaric, acid citric, acid metansulfonic, acid etansulfonic, acid toluensulfonic, la temperatura camerei, aducerea pH-ului la valori 1,5...5, prin adaosul unei baze, alese dintre trietilamin-hidroxid de amoniu, hidroxid de sodiu, hidroxid de potasiu, carbonat de potasiu, carbonat de sodiu, bicarbonat de sodiu, bicarbonat de potasiu sau prin adaos de apa, separarea cristalelor umede obtinute si uscarea lor la temperatura de 10...60 degree C, într-un gaz inert, cu o umiditate spre 15%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO128826A RO98111B1 (ro) | 1987-06-29 | 1987-06-29 | Procedeu pentru prepararea unui hidrat cristalin al acidului 7beta-[(z)-2-(2-aminotiazol-4-il)-4-carboxibutil-2-enoilamino]-3-cefem-4-carboxilic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO128826A RO98111B1 (ro) | 1987-06-29 | 1987-06-29 | Procedeu pentru prepararea unui hidrat cristalin al acidului 7beta-[(z)-2-(2-aminotiazol-4-il)-4-carboxibutil-2-enoilamino]-3-cefem-4-carboxilic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO98111B1 true RO98111B1 (ro) | 1989-10-30 |
Family
ID=40906227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO128826A RO98111B1 (ro) | 1987-06-29 | 1987-06-29 | Procedeu pentru prepararea unui hidrat cristalin al acidului 7beta-[(z)-2-(2-aminotiazol-4-il)-4-carboxibutil-2-enoilamino]-3-cefem-4-carboxilic |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO98111B1 (ro) |
-
1987
- 1987-06-29 RO RO128826A patent/RO98111B1/ro unknown
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