RO87157B1 - Procedeu de obtinere a glicoproteinelor antitumorale - Google Patents
Procedeu de obtinere a glicoproteinelor antitumoraleInfo
- Publication number
- RO87157B1 RO87157B1 RO111816A RO11181683A RO87157B1 RO 87157 B1 RO87157 B1 RO 87157B1 RO 111816 A RO111816 A RO 111816A RO 11181683 A RO11181683 A RO 11181683A RO 87157 B1 RO87157 B1 RO 87157B1
- Authority
- RO
- Romania
- Prior art keywords
- glycoproteins
- tri
- sodium
- acid
- bromide
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 3
- 108090000288 Glycoproteins Proteins 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- -1 sodium hydrobromide tri-n-butylphosphine Chemical compound 0.000 abstract 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 abstract 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 abstract 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 abstract 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 235000010265 sodium sulphite Nutrition 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 abstract 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a glicoproteinelor antitumorale, procedeu ce consta în faptul ca glicoproteinele cu greutate moleculara cuprinsa între 7000-90000 sunt supuse degradarii în prezenta unui agent de reducere ales dintre 2.mercaptoetanol, ditiotreitol, diticeritriol, acid trioglicolic, acid monotiofosforic, bromhidrura de sodiu tri-n-butilfosfina, tri-dietil-aminoetilfosfina, sulfit de sodiu, ionul argint sau bromura de cianogen, la 0...37 degree C de preferinta 15....25 degree C, timp de 10....120 min pH 5,5....7,5 cu sau fara prezenta unui agent de suprafata ales dintre dodecilsulfatul de sodiu, acid calcic, bromura de dodeciltrimerilamoniu, deoxilisolecitina, Tween, Span, Triton, dupa care urmeaza purificarea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO111816A RO87157B1 (ro) | 1983-08-04 | 1983-08-04 | Procedeu de obtinere a glicoproteinelor antitumorale |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO111816A RO87157B1 (ro) | 1983-08-04 | 1983-08-04 | Procedeu de obtinere a glicoproteinelor antitumorale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO87157B1 true RO87157B1 (ro) | 1985-07-31 |
Family
ID=40903818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO111816A RO87157B1 (ro) | 1983-08-04 | 1983-08-04 | Procedeu de obtinere a glicoproteinelor antitumorale |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO87157B1 (ro) |
-
1983
- 1983-08-04 RO RO111816A patent/RO87157B1/ro unknown
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