RO85450B - Process for preparing aminobenzylic acid derivatives - Google Patents

Process for preparing aminobenzylic acid derivatives

Info

Publication number
RO85450B
RO85450B RO105166A RO10516681A RO85450B RO 85450 B RO85450 B RO 85450B RO 105166 A RO105166 A RO 105166A RO 10516681 A RO10516681 A RO 10516681A RO 85450 B RO85450 B RO 85450B
Authority
RO
Romania
Prior art keywords
aminobenzylic
preparing
acid derivatives
general formula
formula
Prior art date
Application number
RO105166A
Other languages
Romanian (ro)
Other versions
RO85450A (en
Inventor
Pamela Koenig Baker
Jane Ann Kiernan
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/219,054 external-priority patent/US4404222A/en
Priority claimed from US06/219,055 external-priority patent/US4407819A/en
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of RO85450A publication Critical patent/RO85450A/en
Publication of RO85450B publication Critical patent/RO85450B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu de preparare a unor derivati ai alcoolului aminobenzilic cu formula generala I: (vezi formula) din bromura de fenacil, corespunzatoare formulei generale II: (vezi formula) în etanol, la 10...20 degree C, amestecul reducîndu-se cu borohidrura de sodiu sau cianborohidrura de sodiu la 0...20 degree C si apoi extrîgîndu-se cu un solvent, ales dintre clorura de metilen si cloroform.The invention relates to a process for the preparation of aminobenzyl alcohol derivatives of general formula I (see formula) from phenacyl bromide of general formula II: (see formula) in ethanol at 10-20 ° C, the mixture reducing with sodium borohydride or sodium cyanoborohydride at 0 DEG-20 DEG C. and then extruding with a solvent selected from methylene chloride and chloroform.

RO105166A 1980-08-25 1981-08-25 Process for preparing aminobenzylic acid derivatives RO85450B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18125480A 1980-08-25 1980-08-25
US18125580A 1980-08-25 1980-08-25
US06/219,054 US4404222A (en) 1980-08-25 1980-12-22 Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby
US06/219,055 US4407819A (en) 1980-08-25 1980-12-22 Phenylethanolamine derivatives and acid addition salts thereof for the depression of fat deposition in warm blooded animals

Publications (2)

Publication Number Publication Date
RO85450A RO85450A (en) 1984-11-25
RO85450B true RO85450B (en) 1984-11-30

Family

ID=27497440

Family Applications (1)

Application Number Title Priority Date Filing Date
RO105166A RO85450B (en) 1980-08-25 1981-08-25 Process for preparing aminobenzylic acid derivatives

Country Status (10)

Country Link
KR (1) KR860001829B1 (en)
AT (1) AT379055B (en)
DD (1) DD208758A5 (en)
DK (1) DK171124B1 (en)
GR (1) GR75746B (en)
HU (1) HU188686B (en)
LU (1) LU83580A1 (en)
NZ (1) NZ196249A (en)
PT (1) PT73560B (en)
RO (1) RO85450B (en)

Also Published As

Publication number Publication date
LU83580A1 (en) 1981-12-01
AT379055B (en) 1985-11-11
ATA368581A (en) 1985-04-15
KR830005656A (en) 1983-09-09
DK374381A (en) 1982-02-26
GR75746B (en) 1984-08-02
DK171124B1 (en) 1996-06-24
HU188686B (en) 1986-05-28
PT73560B (en) 1982-11-09
NZ196249A (en) 1984-09-28
KR860001829B1 (en) 1986-10-24
RO85450A (en) 1984-11-25
PT73560A (en) 1981-09-01
DD208758A5 (en) 1984-04-11

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