RO85130B - Procedeu pentru prepararea unui complex destinat pentru inhibarea proliferarii si migrarii celulelor tumorale - Google Patents

Procedeu pentru prepararea unui complex destinat pentru inhibarea proliferarii si migrarii celulelor tumorale

Info

Publication number
RO85130B
RO85130B RO109102A RO10910282A RO85130B RO 85130 B RO85130 B RO 85130B RO 109102 A RO109102 A RO 109102A RO 10910282 A RO10910282 A RO 10910282A RO 85130 B RO85130 B RO 85130B
Authority
RO
Romania
Prior art keywords
migration
preparation
inhibit
cell proliferation
complex
Prior art date
Application number
RO109102A
Other languages
English (en)
Other versions
RO85130A (ro
Inventor
Richard James Douthart
Walter John Kleinschmidt
Richard Michael Schultz
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/324,241 external-priority patent/US4400375A/en
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO85130A publication Critical patent/RO85130A/ro
Publication of RO85130B publication Critical patent/RO85130B/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedeul pentru prepararea unui complex, destinat pentru inhibarea proliferarii si migrarii celulelor tumorale, consta în aceea ca se combina o aminoglicozida care contine cel putin 5 atomi de azot ionizabil, aleasa dintre tobramicina, streptomicina, neomicina sau apramcina cu acid ribonucleic dublu rasucit, ales dintre poli I: poli C sau derivat din particulele unui virus ce se gaseste în Penicillum chrysogenum, proportia molara dintre aminoglicozida si fosforacid ribonucleic dublu rasucit fiind de 1...40:1, reactia avînd loc la temperatura camerei, timp de o ora, într-un tampon neutru.
RO109102A 1981-11-23 1982-11-23 Procedeu pentru prepararea unui complex destinat pentru inhibarea proliferarii si migrarii celulelor tumorale RO85130B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32424381A 1981-11-23 1981-11-23
US06/324,241 US4400375A (en) 1981-11-23 1981-11-23 Tobramycin-double stranded RNA complex suitable for inducing interferon

Publications (2)

Publication Number Publication Date
RO85130A RO85130A (ro) 1984-09-29
RO85130B true RO85130B (ro) 1984-10-30

Family

ID=26984355

Family Applications (1)

Application Number Title Priority Date Filing Date
RO109102A RO85130B (ro) 1981-11-23 1982-11-23 Procedeu pentru prepararea unui complex destinat pentru inhibarea proliferarii si migrarii celulelor tumorale

Country Status (16)

Country Link
EP (1) EP0080357A1 (ro)
AR (1) AR229715A1 (ro)
AU (1) AU9036082A (ro)
BG (1) BG37077A3 (ro)
CA (1) CA1190492A (ro)
CS (1) CS836982A2 (ro)
DD (1) DD204945A5 (ro)
DK (1) DK519682A (ro)
ES (1) ES517581A0 (ro)
GB (1) GB2110220B (ro)
GR (1) GR77032B (ro)
IL (1) IL67316A0 (ro)
NZ (1) NZ202454A (ro)
PL (1) PL239178A1 (ro)
PT (1) PT75879B (ro)
RO (1) RO85130B (ro)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1170929A (en) * 1965-12-28 1969-11-19 Glaxo Lab Ltd Antirival Nucleic Acids.
US3582469A (en) * 1968-09-27 1971-06-01 Merck & Co Inc Production of double-stranded ribonucleic acid
BE790953A (fr) * 1971-11-05 1973-05-03 Beecham Group Ltd Matiere biologiquement active
GB1440626A (ro) * 1973-05-02 1976-06-23 Farmaceutici Italia

Also Published As

Publication number Publication date
CA1190492A (en) 1985-07-16
CS836982A2 (en) 1985-07-16
NZ202454A (en) 1985-10-11
DK519682A (da) 1983-05-24
PT75879B (en) 1986-01-15
IL67316A0 (en) 1983-03-31
ES8401986A1 (es) 1984-01-01
RO85130A (ro) 1984-09-29
DD204945A5 (de) 1983-12-14
GR77032B (ro) 1984-09-04
GB2110220A (en) 1983-06-15
GB2110220B (en) 1985-02-13
PT75879A (en) 1982-12-01
PL239178A1 (en) 1983-08-01
AU9036082A (en) 1983-06-02
EP0080357A1 (en) 1983-06-01
ES517581A0 (es) 1984-01-01
AR229715A1 (es) 1983-10-31
BG37077A3 (en) 1985-03-15

Similar Documents

Publication Publication Date Title
ES8606289A1 (es) Un procedimiento para la preparacion de piridazinaminas.
UA26437A (uk) Поліолефіhова композиція та спосіб її одержаhhя
IE830227L (en) Pyrazolooxazines
IT1225762B (it) Composti farmacologicamente attivi, procedimenti per la loro preparazione e composizioni che li contengono.
MY102025A (en) Improvements in or relating to novel difluoro antiviral agents
EP0140781A3 (en) Compositions containing heparin derivatives, especially useful in the treatment of disturbances by cell proliferation
IT1147852B (it) Impianto di avviso di prossimita' del suolo per aerei,con commutazione di modo in base al tempo
ES8705403A1 (es) Un procedimiento para la preparacion de bencenoacetonitrilos
ES8604258A1 (es) Un procedimiento para preparar una adenosina sustituida en n6
GB1537566A (en) Restoration of soft contact lenses
PH21350A (en) Tumor cell growth imhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes
ES8606015A1 (es) Un metodo de sintetizar un oxido cristalino utilizable como catalizador para la conversion de compuestos organicos
RO85130B (ro) Procedeu pentru prepararea unui complex destinat pentru inhibarea proliferarii si migrarii celulelor tumorale
EP0058697A4 (en) NOVEL TYPE OF NONA- AND DECA (H -) - RUTINE SULFATES, PROCESSES FOR PREPARING SUCH NEW TYPES OF SALTS, AND USE THEREOF AS COMPLEMENTARY INHIBITORS.
IT1229991B (it) Miglioramenti nella,o relativi alla produzione di semi ibridi
JPS52136159A (en) Anti/malignanttumor containing the same as active ingredients
IT8320921A0 (it) Derivati dall'acido carbazico, procedimento per la loro preparazione e composizioni che ne contengono.
MY101961A (en) 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterease fraction iii inhibiting properties and/or renal vasodilating properties
DE3569371D1 (en) Diphenyl hydrantoin silver complex and uses thereof
BE747476A (fr) Composes d'argent utiles notamment comme agent antibacteriens
BE790380A (fr) Nouvelles (p-chloro) phenyl-1 methyl-3 imidazolidines, 2,4-disubstituees utiles notamment comme agents diuretiques antialdosterone et leur procede de preparation
IT1203115B (it) Sostanza antibiotica,procedimento per fabbricarla e composizioni che la contengono efficaci nell'impedire la crescita di batteri gram-positivi
AU582206B2 (en) Imidazole derivatives,their preparation and therapeutic use
ES8505351A1 (es) Un procedimiento para preparar nuevas aroilimidazolonas
SE8802193D0 (sv) Externally applicable, antiviral pharmaceutical composition accumulating in the skin and process for the preparation of the same