RO81118B1 - Conjugat progesteron-histaminic si procedeu de obtinere a acestuia - Google Patents
Conjugat progesteron-histaminic si procedeu de obtinere a acestuiaInfo
- Publication number
- RO81118B1 RO81118B1 RO102696A RO10269680A RO81118B1 RO 81118 B1 RO81118 B1 RO 81118B1 RO 102696 A RO102696 A RO 102696A RO 10269680 A RO10269680 A RO 10269680A RO 81118 B1 RO81118 B1 RO 81118B1
- Authority
- RO
- Romania
- Prior art keywords
- progesterone
- histaminic
- treated
- reflux temperature
- resulting
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 4
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- 229960003387 progesterone Drugs 0.000 abstract 2
- 239000000186 progesterone Substances 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 abstract 2
- HFSZYSZYZVKKOX-UHPWKVKZSA-N (8s,9s,10r,13s,14s,17s)-17-acetyl-6-bromo-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1C(Br)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 HFSZYSZYZVKKOX-UHPWKVKZSA-N 0.000 abstract 1
- CQWXKASOCUAEOW-UHFFFAOYSA-N 2-[2-(carboxymethoxy)ethoxy]acetic acid Chemical compound OC(=O)COCCOCC(O)=O CQWXKASOCUAEOW-UHFFFAOYSA-N 0.000 abstract 1
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical compound ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003418 antiprogestin Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 230000003623 progesteronic effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
Conjugat progesteron histaminic, caracterizat prin aceea ca, are formula generala I: (vezi formula) cu aspect cristalin solubil în toluen, prezinta activitate specifica 810 miu e miu g serul antiprogesteron, de asemenea, se aduce în reactie progesteron cu N-hemisuccinamida în raport în greutate de circa 1,7:1 la temperatura de reflux a amestecului de reactie folosind ca solvent tetraclorura de carbon, apoi 6-brom-progesterona rezultata cu acid triglicolic, în prezenta de hidroxid alcalin, la temperatura de reflux în mediu metanolic, iar produsul rezultat este tratat cu histamina în prezenta de N-metilmorfolina si cloroformiat de etil la circa 5 degree C, iar produsul rezultat dizolvat în solutia tampon fosfat 0,5 miu cu pH=7,4 este tratat cu solutia de NaI 125 în cloramina, obtinîndu-se produsul de reactie marcat, care este izolat în mod cunoscut.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO80102696A RO81118A2 (ro) | 1980-11-27 | 1980-11-27 | Conjugat progesteron-histaminic si procedeu de obtinere a acestuia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO80102696A RO81118A2 (ro) | 1980-11-27 | 1980-11-27 | Conjugat progesteron-histaminic si procedeu de obtinere a acestuia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO81118B1 true RO81118B1 (ro) | 1983-01-30 |
| RO81118A2 RO81118A2 (ro) | 1983-02-01 |
Family
ID=20109205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO80102696A RO81118A2 (ro) | 1980-11-27 | 1980-11-27 | Conjugat progesteron-histaminic si procedeu de obtinere a acestuia |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO81118A2 (ro) |
-
1980
- 1980-11-27 RO RO80102696A patent/RO81118A2/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO81118A2 (ro) | 1983-02-01 |
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