RO72511B - Process for the hydrogenation of methylene-exocyclic group from 6-methylene-tetracyclic - Google Patents
Process for the hydrogenation of methylene-exocyclic group from 6-methylene-tetracyclicInfo
- Publication number
- RO72511B RO72511B RO77638A RO7763874A RO72511B RO 72511 B RO72511 B RO 72511B RO 77638 A RO77638 A RO 77638A RO 7763874 A RO7763874 A RO 7763874A RO 72511 B RO72511 B RO 72511B
- Authority
- RO
- Romania
- Prior art keywords
- methylene
- hydrogenation
- atom
- carbon atoms
- general formula
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedeu de hidrogenare a grupei metil-exociclice din 6 metilen-tetracicline cu hidrogen gazos, în prezenta de catalizatori, caracterizat prin aceea ca se aduc în reactie tetracicline cu formula generala I: (vezi form. in desc.) în care Y reprezinta un atom de hidrogen, sau o grupa hidroxil, Z reprezinta un atom de hidrogen sau un atom de clor, cu hidrogen gazos sub presiune de 1....120 at, la temperatura de 20....85 degree C, în prezenta unui complex cu formula generala:(vezi form. in desc.) în care R1 si R2 reprezinta radicali inferioara cu 1..4 atomi de carbon, eventual, în prezenta de bromura sau iodura de potasiu în proportie de 0,25....1% greutate fata de masa complecsului, într-un solvent ales din eter-etilenglicol-monometilic, eter etilenglicol-monoetilic, N,N-dimetilformamida sau alcool cu 1....4 atomi de carbon, luat singur sau în amestec, apoi amestecul de reactie este prelucrat, în mod cunoscut, în vederea separarii produsului de reactie.Hydrogenation of the methyl-exocyclic 6-methylene-tetracycline group with hydrogen gas in the presence of catalysts, characterized in that tetracyclines of general formula I are reacted in which Y represents an atom a hydrogen atom or a hydroxyl group, Z represents a hydrogen atom or a chlorine atom, with hydrogen gas under pressure of 1 ... 120 atm at a temperature of 20 ... 85 ° C, in the presence of a complex with the general formula: wherein R 1 and R 2 represent lower radicals of 1 to 4 carbon atoms, optionally in the presence of potassium bromide or iodide in a proportion of 0.25 ... 1 % by weight of the composition in a solvent selected from ethyleneglycol monomethyl ether, ethylene glycol monoethyl ether, N, N-dimethylformamide or alcohol of 1-4 carbon atoms, taken alone or in admixture, then the mixture The reaction is worked up in a known manner to separate the reaction product.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36806073A | 1973-06-08 | 1973-06-08 | |
| US42827873A | 1973-12-26 | 1973-12-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO72511A RO72511A (en) | 1983-04-29 |
| RO72511B true RO72511B (en) | 1983-04-30 |
Family
ID=27004030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO77638A RO72511B (en) | 1973-06-08 | 1974-02-12 | Process for the hydrogenation of methylene-exocyclic group from 6-methylene-tetracyclic |
Country Status (3)
| Country | Link |
|---|---|
| BG (1) | BG29137A3 (en) |
| EG (1) | EG11064A (en) |
| RO (1) | RO72511B (en) |
-
1974
- 1974-02-12 RO RO77638A patent/RO72511B/en unknown
- 1974-02-21 BG BG7425858A patent/BG29137A3/en unknown
- 1974-05-13 EG EG17274A patent/EG11064A/en active
Also Published As
| Publication number | Publication date |
|---|---|
| EG11064A (en) | 1976-11-30 |
| RO72511A (en) | 1983-04-29 |
| BG29137A3 (en) | 1980-09-15 |
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