RO72312B - Procedeu de obtinere a unui derivat de tiouree - Google Patents

Procedeu de obtinere a unui derivat de tiouree

Info

Publication number
RO72312B
RO72312B RO87167A RO8716776A RO72312B RO 72312 B RO72312 B RO 72312B RO 87167 A RO87167 A RO 87167A RO 8716776 A RO8716776 A RO 8716776A RO 72312 B RO72312 B RO 72312B
Authority
RO
Romania
Prior art keywords
thiourea derivative
obtaining
formula
see formulas
amine
Prior art date
Application number
RO87167A
Other languages
English (en)
Other versions
RO72312A (ro
Inventor
George Raymond White
Original Assignee
Smith Kline & French Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline & French Laboratories Limited filed Critical Smith Kline & French Laboratories Limited
Publication of RO72312A publication Critical patent/RO72312A/ro
Publication of RO72312B publication Critical patent/RO72312B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedeu de obtinere a unui derivat de tiouree, farmacologic activ, cu formula I : (vezi formu. în desc.)caracterizat prin aceea ca se trateaza o amina cu formula II:(vezi form. în desc.) cu izocianat de metil, în solutie apoasa etanolica, la temperatura de reflux a amestecului de reactie.
RO87167A 1975-07-31 1976-07-31 Procedeu de obtinere a unui derivat de tiouree RO72312B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB31968/75A GB1565647A (en) 1975-07-31 1975-07-31 Pharmacologically active compounds 4-substituted-imidazole-5-methanols

Publications (2)

Publication Number Publication Date
RO72312A RO72312A (ro) 1984-03-15
RO72312B true RO72312B (ro) 1984-03-31

Family

ID=10331071

Family Applications (1)

Application Number Title Priority Date Filing Date
RO87167A RO72312B (ro) 1975-07-31 1976-07-31 Procedeu de obtinere a unui derivat de tiouree

Country Status (28)

Country Link
JP (1) JPS5219663A (ro)
AR (1) AR213100A1 (ro)
AT (1) AT356668B (ro)
AU (1) AU508262B2 (ro)
BE (1) BE843840A (ro)
CA (1) CA1075702A (ro)
CS (1) CS203054B2 (ro)
DD (1) DD125205A5 (ro)
DE (1) DE2634430A1 (ro)
DK (1) DK316376A (ro)
ES (1) ES450309A1 (ro)
FI (1) FI762191A (ro)
FR (1) FR2319341A1 (ro)
GB (1) GB1565647A (ro)
GR (1) GR61114B (ro)
HU (1) HU174068B (ro)
IL (1) IL50006A0 (ro)
LU (1) LU75495A1 (ro)
NL (1) NL7608505A (ro)
NO (1) NO762659L (ro)
OA (1) OA05405A (ro)
PH (1) PH13417A (ro)
PT (1) PT65377B (ro)
RO (1) RO72312B (ro)
SE (1) SE7608478L (ro)
SU (1) SU655310A3 (ro)
ZA (1) ZA763686B (ro)
ZM (1) ZM9676A1 (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4112234A (en) 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
US4233302A (en) 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
EP0008596A1 (fr) * 1978-09-04 1980-03-19 DEVINTER Europe S.A. Société anonyme dite: Procédé de préparation de dérivés du type 4-hydroxyméthyl imidazole à partir d'esters d'acides 4-imidazole carboxyliques correspondants
US4200760A (en) * 1978-09-26 1980-04-29 Bristol-Myers Company Imidazolylalkylthioalkylamino-ethylene derivatives
JPS5914460B2 (ja) * 1978-12-27 1984-04-04 相互薬工株式会社 Ｈ↓２受容体「きつ」抗剤シメチジンの製造法
CN103288742A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种高纯度英加韦林原料的制备方法
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA938556A (en) * 1970-06-25 1973-12-18 Smith Kline And French Laboratories Limited Pharmaceutical compositions containing thiourea derivatives

Also Published As

Publication number Publication date
SU655310A3 (ru) 1979-03-30
OA05405A (fr) 1981-02-28
JPS5219663A (en) 1977-02-15
AU1644776A (en) 1978-02-02
ES450309A1 (es) 1977-12-01
BE843840A (fr) 1977-01-06
PH13417A (en) 1980-03-30
NO762659L (ro) 1977-02-01
AU508262B2 (en) 1980-03-13
DE2634430A1 (de) 1977-02-10
NL7608505A (nl) 1977-02-02
ATA552376A (de) 1979-10-15
DK316376A (da) 1977-02-01
IL50006A0 (en) 1976-09-30
FR2319341B1 (ro) 1979-01-12
AR213100A1 (es) 1978-12-15
AT356668B (de) 1980-05-12
RO72312A (ro) 1984-03-15
CA1075702A (en) 1980-04-15
PT65377A (en) 1976-08-01
LU75495A1 (ro) 1977-03-03
GR61114B (en) 1978-09-13
FI762191A (ro) 1977-02-01
FR2319341A1 (fr) 1977-02-25
ZA763686B (en) 1977-05-25
DD125205A5 (ro) 1977-04-06
HU174068B (hu) 1979-10-28
CS203054B2 (en) 1981-02-27
GB1565647A (en) 1980-04-23
PT65377B (en) 1978-01-19
SE7608478L (sv) 1977-02-01
ZM9676A1 (en) 1977-07-21

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