RO117318B1 - Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de n,n-dimetilaminoetanol - Google Patents

Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de n,n-dimetilaminoetanol

Info

Publication number
RO117318B1
RO117318B1 RO97-01207A RO9701207A RO117318B1 RO 117318 B1 RO117318 B1 RO 117318B1 RO 9701207 A RO9701207 A RO 9701207A RO 117318 B1 RO117318 B1 RO 117318B1
Authority
RO
Romania
Prior art keywords
dimethyl
sulphonyl
amido
chloro
preparing
Prior art date
Application number
RO97-01207A
Other languages
English (en)
Inventor
Corneliu Oniscu
Cilianu Paul Ştefan Bibian
Dumitru Dobrescu
Lucian Sergiu Harles
Ioana Virginia Dicu
Gabriela Funieru
Alexandru Cârstea
Original Assignee
S.C. " Sintofarm " S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S.C. " Sintofarm " S.A. filed Critical S.C. " Sintofarm " S.A.
Priority to RO97-01207A priority Critical patent/RO117318B1/ro
Priority to PCT/RO1998/000009 priority patent/WO1999000358A1/en
Priority to MD99-0158A priority patent/MD990158A/ro
Priority to EP98932660A priority patent/EP0922026A1/en
Publication of RO117318B1 publication Critical patent/RO117318B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Invenţia se referă la un procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de N,N-dimetilaminoetanol, care constă în transesterificarea esterului 2-clor-4-dimetilamido-sulfonil-fenoxiacetat cu N,N-dimetilaminoetanol la 100°C, timp de 4 h, în prezenţa N,N-dimetilaminoetoxidului de sodiu, drept catalizator, după care esterul uleios, rezultat, se separă din mediul de reacţie, se extrage şi se anhidrizează cu benzen la temperatura de până la 10°C, apoi se tratează soluţia benzenică anhidră cu acid clorhidric gazos, la rece, produsul final fiind purificat prinrecristalizare dintr-un amestec de etanol şi dimetilformamidă.
RO97-01207A 1997-06-30 1997-06-30 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de n,n-dimetilaminoetanol RO117318B1 (ro)

Priority Applications (4)

Application Number Priority Date Filing Date Title
RO97-01207A RO117318B1 (ro) 1997-06-30 1997-06-30 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de n,n-dimetilaminoetanol
PCT/RO1998/000009 WO1999000358A1 (en) 1997-06-30 1998-06-23 Procedure to prepare n,n-dimethylaminoethanol 2-chlor-4-dimethyl-amidosulfonyl-fenoxyacetate hydrochloride
MD99-0158A MD990158A (ro) 1997-06-30 1998-06-23 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amidosulfonil-fenoxiacetat de N,N-dimetilaminoetanol
EP98932660A EP0922026A1 (en) 1997-06-30 1998-06-23 Procedure to prepare n,n-dimethylaminoethanol 2-chlor-4-dimethyl-amidosulfonyl-fenoxyacetate hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO97-01207A RO117318B1 (ro) 1997-06-30 1997-06-30 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de n,n-dimetilaminoetanol

Publications (1)

Publication Number Publication Date
RO117318B1 true RO117318B1 (ro) 2002-01-30

Family

ID=20105274

Family Applications (1)

Application Number Title Priority Date Filing Date
RO97-01207A RO117318B1 (ro) 1997-06-30 1997-06-30 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de n,n-dimetilaminoetanol

Country Status (4)

Country Link
EP (1) EP0922026A1 (ro)
MD (1) MD990158A (ro)
RO (1) RO117318B1 (ro)
WO (1) WO1999000358A1 (ro)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103214382B (zh) * 2013-04-24 2014-04-02 四川省惠达药业有限公司 一种盐酸甲氯芬酯化合物及其药物组合物
CN105106189A (zh) * 2015-09-30 2015-12-02 杨献美 一种促进脑能量代谢的药物盐酸甲氯芬酯组合物
CN105106190A (zh) * 2015-10-09 2015-12-02 杨献美 一种中枢兴奋药盐酸甲氯芬酯组合物
CN105287410A (zh) * 2015-12-01 2016-02-03 青岛华之草医药科技有限公司 治疗外伤性昏迷的药物盐酸甲氯芬酯组合物冻干粉针剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO61526A2 (ro) * 1974-11-22 1977-01-15
RO78977A2 (ro) * 1980-09-20 1982-04-12 Institutul De Cercetari Chimico-Farmaceutice,Ro Procedeu de obtinere a esterilor dimetilaminoetilici ai acizilor amidosulfonilfenoxiacetici
RO110060B1 (ro) * 1993-07-19 1995-01-30 Sc Sintofarm Sa Procedeu de obținere a clorhidraților esterilor dimetilaminoetilici ai acizilor amidosulfonilfenoxiacetici

Also Published As

Publication number Publication date
EP0922026A1 (en) 1999-06-16
WO1999000358A1 (en) 1999-01-07
MD990158A (ro) 2000-09-30

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