PT97659A - Processo biocatalitico para a preparacao de l-(-)-carnitina a partir de crotonobetaina e estirpes de proteus mirabilis para utilizacao no referido processo - Google Patents

Processo biocatalitico para a preparacao de l-(-)-carnitina a partir de crotonobetaina e estirpes de proteus mirabilis para utilizacao no referido processo

Info

Publication number
PT97659A
PT97659A PT97659A PT9765991A PT97659A PT 97659 A PT97659 A PT 97659A PT 97659 A PT97659 A PT 97659A PT 9765991 A PT9765991 A PT 9765991A PT 97659 A PT97659 A PT 97659A
Authority
PT
Portugal
Prior art keywords
carnitine
crotonobetain
structures
proteus mirabilis
preparation
Prior art date
Application number
PT97659A
Other languages
English (en)
Other versions
PT97659B (pt
Inventor
Stuart Shapiro
Manrico Bernardini
Charles J Sih
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of PT97659A publication Critical patent/PT97659A/pt
Publication of PT97659B publication Critical patent/PT97659B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/873—Proteus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT97659A 1990-05-14 1991-05-14 Processo biocatalitico para a preparacao de l-(-)-carnitina a partir de crotonobetaina e estirpes de proteus mirabilis para utilizacao no referido processo PT97659B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47953A IT1240833B (it) 1990-05-14 1990-05-14 Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento

Publications (2)

Publication Number Publication Date
PT97659A true PT97659A (pt) 1992-05-29
PT97659B PT97659B (pt) 1998-09-30

Family

ID=11263576

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97659A PT97659B (pt) 1990-05-14 1991-05-14 Processo biocatalitico para a preparacao de l-(-)-carnitina a partir de crotonobetaina e estirpes de proteus mirabilis para utilizacao no referido processo

Country Status (14)

Country Link
US (1) US5300430A (pt)
EP (1) EP0457735B1 (pt)
JP (1) JP3167739B2 (pt)
KR (1) KR0135116B1 (pt)
AT (1) ATE125570T1 (pt)
CA (1) CA2042425C (pt)
DE (1) DE69111511T2 (pt)
DK (1) DK0457735T3 (pt)
ES (1) ES2075408T3 (pt)
HK (1) HK1005888A1 (pt)
IE (1) IE62149B1 (pt)
IT (1) IT1240833B (pt)
PT (1) PT97659B (pt)
ZA (1) ZA913530B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
ATE257515T1 (de) * 1993-10-08 2004-01-15 Lonza Ag Gene für den butyrobetain/crotonobetain-l- carnitin-stoffwechsel und ihre verwendung zur mikrobiologischen herstellung von l-carnitin
EP0735143B1 (en) * 1995-03-28 1998-11-18 Tanabe Seiyaku Co., Ltd. Process for preparing D-amino acids
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
US6337197B2 (en) * 1998-10-27 2002-01-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Coenzymes useful for the synthesis of L-carnitine
SI1151130T1 (en) 1998-10-27 2005-06-30 Sigma-Tau Coenzyme useful for the synthesis of l-carnitine
US6746530B2 (en) 2001-08-02 2004-06-08 Chunghwa Pictures Tubes, Ltd. High contrast, moisture resistant antistatic/antireflective coating for CRT display screen
EP1869199B1 (en) * 2005-04-15 2010-01-06 Council Of Scientific And Industrial Research A chemoenzymatic process for the stereoselective preparation of (r)-gamma-amino-beta-hydroxybutyric acid ((r) -gabob) and (r)-carnitine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
EP0320460B1 (en) * 1987-10-26 1994-04-27 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Process for isolating the enzyme carnitinehydrolyase from strains belonging to the family enterobacteriaceae and use of the immobilized enzyme for producing L(-)-carnitine
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento

Also Published As

Publication number Publication date
EP0457735A1 (en) 1991-11-21
JP3167739B2 (ja) 2001-05-21
PT97659B (pt) 1998-09-30
IE62149B1 (en) 1994-12-14
KR910020171A (ko) 1991-12-19
HK1005888A1 (en) 1999-01-29
ATE125570T1 (de) 1995-08-15
CA2042425C (en) 2000-07-11
IT1240833B (it) 1993-12-17
ES2075408T3 (es) 1995-10-01
JPH04228065A (ja) 1992-08-18
KR0135116B1 (ko) 1998-04-15
IE911637A1 (en) 1991-11-20
DE69111511T2 (de) 1996-01-04
IT9047953A0 (it) 1990-05-14
IT9047953A1 (it) 1991-11-14
ZA913530B (en) 1992-02-26
US5300430A (en) 1994-04-05
DK0457735T3 (da) 1995-09-11
CA2042425A1 (en) 1991-11-15
DE69111511D1 (de) 1995-08-31
EP0457735B1 (en) 1995-07-26

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920106

FG3A Patent granted, date of granting

Effective date: 19980602

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20061204