PT96714A - Processo para a preparacao de receptores acoplados a proteina g hibrida - Google Patents

Processo para a preparacao de receptores acoplados a proteina g hibrida

Info

Publication number
PT96714A
PT96714A PT96714A PT9671491A PT96714A PT 96714 A PT96714 A PT 96714A PT 96714 A PT96714 A PT 96714A PT 9671491 A PT9671491 A PT 9671491A PT 96714 A PT96714 A PT 96714A
Authority
PT
Portugal
Prior art keywords
protein
coupled
domain
receptors
hybrid
Prior art date
Application number
PT96714A
Other languages
English (en)
Other versions
PT96714B (pt
Inventor
Andrzej Z Sledziewski
Paul O Sheppard
Original Assignee
Zymogenetics In
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics In filed Critical Zymogenetics In
Publication of PT96714A publication Critical patent/PT96714A/pt
Publication of PT96714B publication Critical patent/PT96714B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT96714A 1990-02-08 1991-02-08 Processo para a preparacao de receptores acoplados a proteina g hibrida PT96714B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/478,100 US5284746A (en) 1990-02-08 1990-02-08 Methods of producing hybrid G protein-coupled receptors

Publications (2)

Publication Number Publication Date
PT96714A true PT96714A (pt) 1991-10-31
PT96714B PT96714B (pt) 1998-07-31

Family

ID=23898515

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96714A PT96714B (pt) 1990-02-08 1991-02-08 Processo para a preparacao de receptores acoplados a proteina g hibrida

Country Status (14)

Country Link
US (2) US5284746A (pt)
EP (1) EP0594594B1 (pt)
JP (1) JP3333506B2 (pt)
AT (1) ATE152479T1 (pt)
AU (1) AU7333691A (pt)
CA (1) CA2074837C (pt)
CS (1) CS31391A2 (pt)
DE (1) DE69125953T2 (pt)
DK (1) DK0594594T3 (pt)
ES (1) ES2100947T3 (pt)
GR (1) GR3023898T3 (pt)
IE (1) IE63987B1 (pt)
PT (1) PT96714B (pt)
WO (1) WO1991012273A2 (pt)

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ATE207118T1 (de) * 1993-03-31 2001-11-15 Cadus Pharmaceutical Corp Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer
US7235648B1 (en) 1993-03-31 2007-06-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US7416881B1 (en) * 1993-03-31 2008-08-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6255059B1 (en) * 1993-03-31 2001-07-03 Cadus Pharmaceutical Corporation Methods for identifying G protein coupled receptor effectors
US20030054402A1 (en) * 1993-03-31 2003-03-20 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US6864060B1 (en) * 1993-03-31 2005-03-08 Cadus Technologies, Inc. Yeast cells expressing modified G proteins and methods of use therefor
US6100042A (en) * 1993-03-31 2000-08-08 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6537764B1 (en) * 1995-01-19 2003-03-25 Children's Medical Center Corporation Method of identifying inhibitors of C—C chemokine receptor 3
US6806061B1 (en) 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor
US6881545B1 (en) 1995-12-28 2005-04-19 Takeda Chemical Industries, Ltd. Polypeptides, their production and use
CN1149286C (zh) 1995-12-28 2004-05-12 武田药品工业株式会社 G蛋白偶联受体蛋白的配体多肽及其生产方法和用途
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6355473B1 (en) 1998-05-06 2002-03-12 Cadus Pharmaceutical Corp. Yeast cells having mutations in stp22 and uses therefor
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US7081360B2 (en) * 1998-07-28 2006-07-25 Cadus Technologies, Inc. Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
US7273747B2 (en) 1998-08-27 2007-09-25 Cadus Technologies, Inc. Cell having amplified signal transduction pathway responses and uses therefor
US7094593B1 (en) * 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
US6251605B1 (en) 1998-10-27 2001-06-26 Cadus Pharmaceutical Corporation Yeast cells having mutations in Cav1 and uses therefor
WO2000031261A2 (en) 1998-11-25 2000-06-02 Cadus Pharmaceutical Corporation Methods and compositions for identifying effectors of the formyl peptide receptor like-1 (fprl-1) receptor
US6504008B1 (en) 1999-02-01 2003-01-07 Cadus Technologies, Inc. Cell based signal generation
WO2000075660A1 (en) * 1999-06-08 2000-12-14 The Regents Of The University Of California Methods and compositions for identifying inhibitors of osteoclastic bone reabsorption
US6555325B1 (en) 1999-06-14 2003-04-29 Cadus Technologies, Inc. System for detection of a functional interaction between a compound and a cellular signal transduction component
US7223533B2 (en) 1999-09-10 2007-05-29 Cadus Technologies, Inc. Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
US7324236B2 (en) * 2000-02-01 2008-01-29 Canon Kabushiki Kaisha Discrepancy correction method and apparatus for correcting difference in levels of image signals obtained by an image sensor having a multiple output channels
US20040219525A1 (en) 2000-08-25 2004-11-04 Heiko Haertel Plant polynucleotides encoding novel prenyl proteases
US20050136431A1 (en) * 2000-11-03 2005-06-23 Oakley Robert H. Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7163800B2 (en) * 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7018812B2 (en) 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
EP1326076A3 (en) * 2001-10-26 2004-01-28 Millenium Pharmaceuticals, Inc. Methods for indentification of ligands or modulators of 2871 receptor, a g-protein coupled receptor
AU2003202297C1 (en) 2002-01-25 2006-05-18 G2 Therapies Ltd Anti-C5aR antibodies and uses thereof
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
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MX2008013394A (es) * 2006-04-21 2008-10-31 Wyeth Corp Metodos para tamizado de alta emision de lineas celulares.
CA2660156A1 (en) * 2006-08-22 2008-02-28 G2 Inflammation Pty Ltd Anti-c5ar antibodies with improved properties
KR20100117120A (ko) 2008-02-20 2010-11-02 지투 인플레메이션 피티와이 엘티디 인간화된 항-Ｃ5ａＲ 항체
ES2693647T3 (es) 2011-06-06 2018-12-13 Novo Nordisk A/S Anticuerpos terapéuticos
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US4745057A (en) * 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
US4931373A (en) * 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
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US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal

Also Published As

Publication number Publication date
US5284746A (en) 1994-02-08
EP0594594B1 (en) 1997-05-02
ES2100947T3 (es) 1997-07-01
PT96714B (pt) 1998-07-31
DK0594594T3 (da) 1997-09-29
WO1991012273A3 (en) 1991-10-03
WO1991012273A2 (en) 1991-08-22
DE69125953D1 (de) 1997-06-05
DE69125953T2 (de) 1997-08-21
US5576210A (en) 1996-11-19
CA2074837A1 (en) 1991-08-09
CA2074837C (en) 2001-11-27
IE63987B1 (en) 1995-06-28
EP0594594A1 (en) 1994-05-04
ATE152479T1 (de) 1997-05-15
CS31391A2 (en) 1991-11-12
IE910430A1 (en) 1991-08-14
GR3023898T3 (en) 1997-09-30
JPH05504258A (ja) 1993-07-08
AU7333691A (en) 1991-09-03
JP3333506B2 (ja) 2002-10-15

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Legal Events

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BB1A Laying open of patent application

Effective date: 19910702

FG3A Patent granted, date of granting

Effective date: 19980406

PD3A Change of proprietorship

Free format text: WYETH HOLDINGS CORPORATION US

Effective date: 20031117

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20111006