GR3023898T3 - Methods of producing hybrid g protein-coupled receptors - Google Patents

Methods of producing hybrid g protein-coupled receptors

Info

Publication number
GR3023898T3
GR3023898T3 GR970401545T GR970401545T GR3023898T3 GR 3023898 T3 GR3023898 T3 GR 3023898T3 GR 970401545 T GR970401545 T GR 970401545T GR 970401545 T GR970401545 T GR 970401545T GR 3023898 T3 GR3023898 T3 GR 3023898T3
Authority
GR
Greece
Prior art keywords
protein
domain
coupled
methods
coupled receptors
Prior art date
Application number
GR970401545T
Other languages
English (en)
Inventor
Andrzej Z Sledziewski
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of GR3023898T3 publication Critical patent/GR3023898T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR970401545T 1990-02-08 1997-06-26 Methods of producing hybrid g protein-coupled receptors GR3023898T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/478,100 US5284746A (en) 1990-02-08 1990-02-08 Methods of producing hybrid G protein-coupled receptors
PCT/US1991/000909 WO1991012273A2 (en) 1990-02-08 1991-02-08 Methods of producing hybrid g protein-coupled receptors

Publications (1)

Publication Number Publication Date
GR3023898T3 true GR3023898T3 (en) 1997-09-30

Family

ID=23898515

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401545T GR3023898T3 (en) 1990-02-08 1997-06-26 Methods of producing hybrid g protein-coupled receptors

Country Status (14)

Country Link
US (2) US5284746A (el)
EP (1) EP0594594B1 (el)
JP (1) JP3333506B2 (el)
AT (1) ATE152479T1 (el)
AU (1) AU7333691A (el)
CA (1) CA2074837C (el)
CS (1) CS31391A2 (el)
DE (1) DE69125953T2 (el)
DK (1) DK0594594T3 (el)
ES (1) ES2100947T3 (el)
GR (1) GR3023898T3 (el)
IE (1) IE63987B1 (el)
PT (1) PT96714B (el)
WO (1) WO1991012273A2 (el)

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AU652576B2 (en) * 1990-09-13 1994-09-01 Duke University Expression of G protein coupled receptors in yeast
US5264565A (en) * 1991-01-22 1993-11-23 Affymax Technologies, N.V. Nucleic acid encoding the D2 /Ml chimeric receptor
AU655850B2 (en) * 1991-10-01 1995-01-12 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The A method of identifying ligands and antagonists of ligands
DE4138621A1 (de) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
ATE207118T1 (de) * 1993-03-31 2001-11-15 Cadus Pharmaceutical Corp Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer
US7235648B1 (en) 1993-03-31 2007-06-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US7416881B1 (en) * 1993-03-31 2008-08-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6255059B1 (en) * 1993-03-31 2001-07-03 Cadus Pharmaceutical Corporation Methods for identifying G protein coupled receptor effectors
US20030054402A1 (en) * 1993-03-31 2003-03-20 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US6864060B1 (en) * 1993-03-31 2005-03-08 Cadus Technologies, Inc. Yeast cells expressing modified G proteins and methods of use therefor
US6100042A (en) * 1993-03-31 2000-08-08 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6537764B1 (en) * 1995-01-19 2003-03-25 Children's Medical Center Corporation Method of identifying inhibitors of C—C chemokine receptor 3
US6806061B1 (en) 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor
US6881545B1 (en) 1995-12-28 2005-04-19 Takeda Chemical Industries, Ltd. Polypeptides, their production and use
CN1149286C (zh) 1995-12-28 2004-05-12 武田药品工业株式会社 G蛋白偶联受体蛋白的配体多肽及其生产方法和用途
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6355473B1 (en) 1998-05-06 2002-03-12 Cadus Pharmaceutical Corp. Yeast cells having mutations in stp22 and uses therefor
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US7081360B2 (en) * 1998-07-28 2006-07-25 Cadus Technologies, Inc. Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
US7273747B2 (en) 1998-08-27 2007-09-25 Cadus Technologies, Inc. Cell having amplified signal transduction pathway responses and uses therefor
US7094593B1 (en) * 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
US6251605B1 (en) 1998-10-27 2001-06-26 Cadus Pharmaceutical Corporation Yeast cells having mutations in Cav1 and uses therefor
WO2000031261A2 (en) 1998-11-25 2000-06-02 Cadus Pharmaceutical Corporation Methods and compositions for identifying effectors of the formyl peptide receptor like-1 (fprl-1) receptor
US6504008B1 (en) 1999-02-01 2003-01-07 Cadus Technologies, Inc. Cell based signal generation
WO2000075660A1 (en) * 1999-06-08 2000-12-14 The Regents Of The University Of California Methods and compositions for identifying inhibitors of osteoclastic bone reabsorption
US6555325B1 (en) 1999-06-14 2003-04-29 Cadus Technologies, Inc. System for detection of a functional interaction between a compound and a cellular signal transduction component
US7223533B2 (en) 1999-09-10 2007-05-29 Cadus Technologies, Inc. Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
US7324236B2 (en) * 2000-02-01 2008-01-29 Canon Kabushiki Kaisha Discrepancy correction method and apparatus for correcting difference in levels of image signals obtained by an image sensor having a multiple output channels
US20040219525A1 (en) 2000-08-25 2004-11-04 Heiko Haertel Plant polynucleotides encoding novel prenyl proteases
US20050136431A1 (en) * 2000-11-03 2005-06-23 Oakley Robert H. Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7163800B2 (en) * 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7018812B2 (en) 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
EP1326076A3 (en) * 2001-10-26 2004-01-28 Millenium Pharmaceuticals, Inc. Methods for indentification of ligands or modulators of 2871 receptor, a g-protein coupled receptor
AU2003202297C1 (en) 2002-01-25 2006-05-18 G2 Therapies Ltd Anti-C5aR antibodies and uses thereof
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
CN1894581B (zh) * 2003-07-09 2012-02-01 生命技术公司 检测蛋白-蛋白相互作用的方法
MXPA06000176A (es) 2003-12-10 2006-06-27 Millennium Pharm Inc Anticuerpos anti-ccr2 humanizados y sus metodos de uso.
WO2006135382A2 (en) * 2004-08-04 2006-12-21 Chemocentryx, Inc. Enzymatic activities in chemokine-mediated inflammation
MX2008013394A (es) * 2006-04-21 2008-10-31 Wyeth Corp Metodos para tamizado de alta emision de lineas celulares.
CA2660156A1 (en) * 2006-08-22 2008-02-28 G2 Inflammation Pty Ltd Anti-c5ar antibodies with improved properties
KR20100117120A (ko) 2008-02-20 2010-11-02 지투 인플레메이션 피티와이 엘티디 인간화된 항-Ｃ5ａＲ 항체
ES2693647T3 (es) 2011-06-06 2018-12-13 Novo Nordisk A/S Anticuerpos terapéuticos
US9809862B2 (en) * 2014-08-11 2017-11-07 Georgia Tech Research Corporation G-protein coupled receptor (GPCR)-based biosensors and uses thereof

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US4745057A (en) * 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
US4931373A (en) * 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
EP0351921A3 (en) * 1988-07-22 1991-07-17 Merck & Co. Inc. Modified beta adrenergic receptor
US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal

Also Published As

Publication number Publication date
US5284746A (en) 1994-02-08
EP0594594B1 (en) 1997-05-02
ES2100947T3 (es) 1997-07-01
PT96714B (pt) 1998-07-31
DK0594594T3 (da) 1997-09-29
WO1991012273A3 (en) 1991-10-03
WO1991012273A2 (en) 1991-08-22
DE69125953D1 (de) 1997-06-05
DE69125953T2 (de) 1997-08-21
US5576210A (en) 1996-11-19
CA2074837A1 (en) 1991-08-09
CA2074837C (en) 2001-11-27
IE63987B1 (en) 1995-06-28
EP0594594A1 (en) 1994-05-04
PT96714A (pt) 1991-10-31
ATE152479T1 (de) 1997-05-15
CS31391A2 (en) 1991-11-12
IE910430A1 (en) 1991-08-14
JPH05504258A (ja) 1993-07-08
AU7333691A (en) 1991-09-03
JP3333506B2 (ja) 2002-10-15

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