PT942754E - Conjugados uteis no tratamento do cancro da prostata - Google Patents
Conjugados uteis no tratamento do cancro da prostataInfo
- Publication number
- PT942754E PT942754E PT97946296T PT97946296T PT942754E PT 942754 E PT942754 E PT 942754E PT 97946296 T PT97946296 T PT 97946296T PT 97946296 T PT97946296 T PT 97946296T PT 942754 E PT942754 E PT 942754E
- Authority
- PT
- Portugal
- Prior art keywords
- ugly
- conjugates
- treatment
- prostate cancer
- prostate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2922496P | 1996-10-30 | 1996-10-30 | |
| GBGB9626309.0A GB9626309D0 (en) | 1996-12-18 | 1996-12-18 | Conjugates useful in the treatment of prostate cancer |
| US4292197P | 1997-04-04 | 1997-04-04 | |
| GBGB9718160.6A GB9718160D0 (en) | 1997-08-28 | 1997-08-28 | Conjugates useful in the treatment of prostate cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT942754E true PT942754E (pt) | 2003-08-29 |
Family
ID=27451580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97946296T PT942754E (pt) | 1996-10-30 | 1997-10-27 | Conjugados uteis no tratamento do cancro da prostata |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0942754B1 (pt) |
| JP (1) | JP2000509407A (pt) |
| KR (1) | KR100508199B1 (pt) |
| AR (1) | AR008907A1 (pt) |
| AT (1) | ATE239509T1 (pt) |
| AU (1) | AU726434B2 (pt) |
| BG (1) | BG64768B1 (pt) |
| BR (1) | BR9712589A (pt) |
| CA (1) | CA2268738A1 (pt) |
| CO (1) | CO4930281A1 (pt) |
| CZ (1) | CZ155599A3 (pt) |
| DE (1) | DE69721810T2 (pt) |
| DK (1) | DK0942754T3 (pt) |
| DZ (1) | DZ2333A1 (pt) |
| EA (1) | EA002066B1 (pt) |
| EE (1) | EE03858B1 (pt) |
| ES (1) | ES2196374T3 (pt) |
| HK (1) | HK1024876A1 (pt) |
| HR (1) | HRP970566A2 (pt) |
| HU (1) | HUP0000651A3 (pt) |
| ID (1) | ID21358A (pt) |
| IL (1) | IL129356A0 (pt) |
| IS (1) | IS5025A (pt) |
| NO (1) | NO992069L (pt) |
| PE (1) | PE17399A1 (pt) |
| PL (1) | PL333004A1 (pt) |
| PT (1) | PT942754E (pt) |
| SK (1) | SK57399A3 (pt) |
| TR (1) | TR199901485T2 (pt) |
| TW (1) | TW425286B (pt) |
| WO (1) | WO1998018493A2 (pt) |
| YU (1) | YU21399A (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001525337A (ja) * | 1997-12-02 | 2001-12-11 | メルク エンド カムパニー インコーポレーテッド | 前立腺癌の治療に有効なコンジュゲート |
| CA2238257A1 (en) * | 1998-05-22 | 1999-11-22 | Universite De Montreal | Endocytosis of amf-r and uses thereof in cancer therapy |
| AU764603B2 (en) * | 1998-07-17 | 2003-08-21 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Water-soluble drugs and methods for their production |
| US6174858B1 (en) | 1998-11-17 | 2001-01-16 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| PT1144011E (pt) * | 1998-12-11 | 2010-06-16 | Coulter Pharm Inc | Compostos pró-fármacos e processo para a sua preparação |
| CA2388700A1 (en) | 1999-10-19 | 2001-04-26 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| GB9924759D0 (en) * | 1999-10-19 | 1999-12-22 | Merck Sharp & Dohme | Process for preparing peptide intermediates |
| AU781531B2 (en) * | 1999-10-27 | 2005-05-26 | Merck & Co., Inc. | Salt form of a conjugate useful in the treatment of prostate cancer |
| AU4583601A (en) * | 2000-03-15 | 2001-09-24 | Du Pont Pharm Co | Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use |
| CN1649614A (zh) * | 2002-02-22 | 2005-08-03 | 新河药品股份有限公司 | 活性剂传递系统和保护及施用活性剂的方法 |
| WO2005035003A2 (en) * | 2003-09-22 | 2005-04-21 | Dihedron Corporation | Compositions and methods for increasing drug efficiency |
| CN100372862C (zh) * | 2003-11-05 | 2008-03-05 | 天津和美生物技术有限公司 | 具有抗癌活性的阿霉素衍生物及其制备方法和应用 |
| US8518891B2 (en) * | 2006-11-29 | 2013-08-27 | Longqin Hu | Chemotherapeutic conjugates and methods of use |
| CN101225094A (zh) * | 2007-01-18 | 2008-07-23 | 天津和美生物技术有限公司 | 具有抗癌活性的蒽醌四环类化合物 |
| AU2010223565B2 (en) * | 2009-03-09 | 2016-06-23 | Ktb Tumorforschungsgesellschaft Mbh | Prodrugs |
| CN103561771B (zh) | 2011-03-17 | 2019-01-04 | 伯明翰大学 | 重新定向的免疫治疗 |
| CN117736134A (zh) | 2012-01-12 | 2024-03-22 | 耶鲁大学 | 通过e3泛素连接酶增强靶蛋白质及其他多肽降解的化合物和方法 |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US10441649B2 (en) | 2015-02-02 | 2019-10-15 | The University Of Birmingham | Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes |
| CN112807429A (zh) | 2015-11-19 | 2021-05-18 | 雷维托普有限公司 | 用于对非所要细胞进行重定向杀灭的两组分系统的功能性抗体片段互补作用 |
| CA3203072A1 (en) | 2020-12-22 | 2022-06-30 | Andrea CASAZZA | Compounds comprising a tetrapeptidic moiety |
| WO2022167664A1 (en) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143864A (en) * | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
| US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| AU708475B2 (en) * | 1995-10-18 | 1999-08-05 | Merck & Co., Inc. | Conjugates useful in the treatment of benign prostatic hyperplasia |
-
1997
- 1997-10-24 HR HR9718160.6A patent/HRP970566A2/hr not_active Application Discontinuation
- 1997-10-27 TR TR1999/01485T patent/TR199901485T2/xx unknown
- 1997-10-27 CZ CZ991555A patent/CZ155599A3/cs unknown
- 1997-10-27 YU YU21399A patent/YU21399A/sh unknown
- 1997-10-27 CA CA002268738A patent/CA2268738A1/en not_active Abandoned
- 1997-10-27 SK SK573-99A patent/SK57399A3/sk unknown
- 1997-10-27 IL IL12935697A patent/IL129356A0/xx not_active IP Right Cessation
- 1997-10-27 ES ES97946296T patent/ES2196374T3/es not_active Expired - Lifetime
- 1997-10-27 EE EEP199900179A patent/EE03858B1/xx not_active IP Right Cessation
- 1997-10-27 PL PL97333004A patent/PL333004A1/xx unknown
- 1997-10-27 KR KR10-1999-7003846A patent/KR100508199B1/ko not_active IP Right Cessation
- 1997-10-27 AT AT97946296T patent/ATE239509T1/de not_active IP Right Cessation
- 1997-10-27 BR BR9712589-0A patent/BR9712589A/pt not_active Application Discontinuation
- 1997-10-27 WO PCT/US1997/019225 patent/WO1998018493A2/en not_active Application Discontinuation
- 1997-10-27 ID IDW990259A patent/ID21358A/id unknown
- 1997-10-27 EA EA199900428A patent/EA002066B1/ru not_active IP Right Cessation
- 1997-10-27 DK DK97946296T patent/DK0942754T3/da active
- 1997-10-27 PT PT97946296T patent/PT942754E/pt unknown
- 1997-10-27 AU AU51497/98A patent/AU726434B2/en not_active Ceased
- 1997-10-27 DE DE69721810T patent/DE69721810T2/de not_active Expired - Fee Related
- 1997-10-27 HU HU0000651A patent/HUP0000651A3/hu unknown
- 1997-10-27 EP EP97946296A patent/EP0942754B1/en not_active Expired - Lifetime
- 1997-10-27 JP JP10520593A patent/JP2000509407A/ja not_active Ceased
- 1997-10-28 TW TW086115986A patent/TW425286B/zh not_active IP Right Cessation
- 1997-10-28 CO CO97063170A patent/CO4930281A1/es unknown
- 1997-10-29 PE PE1997000970A patent/PE17399A1/es not_active Application Discontinuation
- 1997-10-29 AR ARP970105032A patent/AR008907A1/es not_active Application Discontinuation
- 1997-10-29 DZ DZ970183A patent/DZ2333A1/xx active
-
1999
- 1999-04-13 IS IS5025A patent/IS5025A/is unknown
- 1999-04-29 NO NO992069A patent/NO992069L/no not_active Application Discontinuation
- 1999-05-26 BG BG103436A patent/BG64768B1/bg unknown
-
2000
- 2000-07-07 HK HK00104189A patent/HK1024876A1/xx not_active IP Right Cessation
Also Published As
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