PT91057A - Processo de preparacao de composicoes farmaceuticas com actividade broncodilatadora, a base de derivados de benzotiofeno, benzofurano, di- hidronaftaleno e de indeno - Google Patents
Processo de preparacao de composicoes farmaceuticas com actividade broncodilatadora, a base de derivados de benzotiofeno, benzofurano, di- hidronaftaleno e de indenoInfo
- Publication number
- PT91057A PT91057A PT91057A PT9105789A PT91057A PT 91057 A PT91057 A PT 91057A PT 91057 A PT91057 A PT 91057A PT 9105789 A PT9105789 A PT 9105789A PT 91057 A PT91057 A PT 91057A
- Authority
- PT
- Portugal
- Prior art keywords
- dihydrofolatalene
- bronchodylating
- benzotiophene
- indigenous
- benzofuran
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/16—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88306121 | 1988-07-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT91057A true PT91057A (pt) | 1990-02-08 |
| PT91057B PT91057B (pt) | 1994-12-30 |
Family
ID=8200128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT91057A PT91057B (pt) | 1988-07-05 | 1989-07-04 | Processo de preparacao de composicoes farmaceuticas com actividade broncodilatadora, a base de derivados de benzotiofeno, benzofurano, di- hidronaftaleno e de indeno |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5026724A (pt) |
| EP (1) | EP0352832B1 (pt) |
| JP (1) | JPH0285241A (pt) |
| KR (1) | KR900001675A (pt) |
| AU (1) | AU619567B2 (pt) |
| DE (1) | DE68901424D1 (pt) |
| DK (1) | DK332489A (pt) |
| ES (1) | ES2051986T3 (pt) |
| FI (1) | FI893248A (pt) |
| GR (1) | GR3005347T3 (pt) |
| IE (1) | IE60969B1 (pt) |
| NZ (1) | NZ229773A (pt) |
| PT (1) | PT91057B (pt) |
| ZA (1) | ZA894880B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE913683A1 (en) * | 1990-10-26 | 1992-05-22 | Akzo Nv | USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE |
| US5276052A (en) * | 1990-10-26 | 1994-01-04 | Akzo N.V. | Use of a benzo[b]thiopene-2-carboximidamide derivative |
| US5340833A (en) * | 1992-05-01 | 1994-08-23 | Eisai Co., Ltd. | Urokinase inhibitors |
| DE4321444A1 (de) * | 1993-06-28 | 1995-01-05 | Bernd Prof Dr Clement | Pharmazeutische Zubereitung |
| US5955495A (en) * | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
| US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| MX2007013977A (es) | 2005-05-10 | 2008-02-05 | Incyte Corp | Moduladores de 2,3-dioxigenasa indolamina y metodos de uso de los mismos. |
| CA2634198C (en) | 2005-12-20 | 2014-06-03 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| ES2444574T3 (es) | 2006-09-19 | 2014-02-25 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa |
| KR101847107B1 (ko) | 2008-07-08 | 2018-04-10 | 인사이트 홀딩스 코포레이션 | 인돌아민 ２,３-디옥시게나아제의 억제제로서의 １,２,５-옥사디아졸 |
| TWI696618B (zh) | 2013-11-08 | 2020-06-21 | 美商英塞特控股公司 | 用於合成吲哚胺2,3-雙加氧酶抑制劑之方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1229580A (pt) * | 1967-12-15 | 1971-04-28 | ||
| US3910955A (en) * | 1970-12-21 | 1975-10-07 | Aspro Nicholas Ltd | Benzothiophene-ethylamines |
| US4158015A (en) * | 1978-08-16 | 1979-06-12 | Mobil Oil Corporation | Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes |
| US4737519A (en) * | 1983-12-14 | 1988-04-12 | The Upjohn Company | Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors |
| GB8406906D0 (en) * | 1984-03-16 | 1984-04-18 | Akzo Nv | Benzo-thiazole and benzothiophene derivatives |
| GB8508588D0 (en) * | 1985-04-02 | 1985-05-09 | Akzo Nv | Indene & napthalene derivatives |
-
1989
- 1989-06-21 EP EP89201621A patent/EP0352832B1/en not_active Expired - Lifetime
- 1989-06-21 DE DE8989201621T patent/DE68901424D1/de not_active Expired - Fee Related
- 1989-06-21 ES ES89201621T patent/ES2051986T3/es not_active Expired - Lifetime
- 1989-06-22 IE IE203889A patent/IE60969B1/en not_active IP Right Cessation
- 1989-06-27 ZA ZA894880A patent/ZA894880B/xx unknown
- 1989-06-29 NZ NZ229773A patent/NZ229773A/en unknown
- 1989-07-04 AU AU37837/89A patent/AU619567B2/en not_active Ceased
- 1989-07-04 DK DK332489A patent/DK332489A/da not_active Application Discontinuation
- 1989-07-04 PT PT91057A patent/PT91057B/pt active IP Right Grant
- 1989-07-04 FI FI893248A patent/FI893248A/fi not_active Application Discontinuation
- 1989-07-04 KR KR1019890009472A patent/KR900001675A/ko not_active Application Discontinuation
- 1989-07-05 US US07/375,654 patent/US5026724A/en not_active Expired - Fee Related
- 1989-07-05 JP JP1173892A patent/JPH0285241A/ja active Pending
-
1992
- 1992-08-05 GR GR920401685T patent/GR3005347T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI893248A (fi) | 1990-01-06 |
| EP0352832A1 (en) | 1990-01-31 |
| DK332489A (da) | 1990-01-06 |
| ES2051986T3 (es) | 1994-07-01 |
| DE68901424D1 (de) | 1992-06-11 |
| IE892038L (en) | 1990-01-05 |
| AU3783789A (en) | 1990-01-11 |
| KR900001675A (ko) | 1990-02-27 |
| IE60969B1 (en) | 1994-09-07 |
| PT91057B (pt) | 1994-12-30 |
| ZA894880B (en) | 1990-03-28 |
| US5026724A (en) | 1991-06-25 |
| DK332489D0 (da) | 1989-07-04 |
| EP0352832B1 (en) | 1992-05-06 |
| FI893248A0 (fi) | 1989-07-04 |
| JPH0285241A (ja) | 1990-03-26 |
| GR3005347T3 (pt) | 1993-05-24 |
| NZ229773A (en) | 1991-12-23 |
| AU619567B2 (en) | 1992-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19940620 |