PT89746B - Processo para a preparacao de derivados de isoquinolina - Google Patents
Processo para a preparacao de derivados de isoquinolinaInfo
- Publication number
- PT89746B PT89746B PT89746A PT8974689A PT89746B PT 89746 B PT89746 B PT 89746B PT 89746 A PT89746 A PT 89746A PT 8974689 A PT8974689 A PT 8974689A PT 89746 B PT89746 B PT 89746B
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- group
- hydrogen
- same
- different
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888803919A GB8803919D0 (en) | 1988-02-19 | 1988-02-19 | Novel compounds |
GB888815089A GB8815089D0 (en) | 1988-06-24 | 1988-06-24 | Novel compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
PT89746A PT89746A (pt) | 1989-10-04 |
PT89746B true PT89746B (pt) | 1994-03-31 |
Family
ID=26293513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT89746A PT89746B (pt) | 1988-02-19 | 1989-02-17 | Processo para a preparacao de derivados de isoquinolina |
Country Status (12)
Country | Link |
---|---|
US (1) | US4954509A (pt) |
EP (1) | EP0330360B1 (pt) |
JP (1) | JPH0219379A (pt) |
AT (1) | ATE97893T1 (pt) |
AU (1) | AU620845B2 (pt) |
CA (1) | CA1333067C (pt) |
DE (1) | DE68910999T2 (pt) |
DK (1) | DK75589A (pt) |
ES (1) | ES2061972T3 (pt) |
IE (1) | IE62031B1 (pt) |
NZ (1) | NZ228032A (pt) |
PT (1) | PT89746B (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT89780A (pt) * | 1988-02-23 | 1989-10-04 | Glaxo Group Ltd | Processo para a preparacao de derivados da tetrahidroisoquinolina |
GB8824400D0 (en) * | 1988-10-18 | 1988-11-23 | Glaxo Group Ltd | Chemical compounds |
GB8827479D0 (en) * | 1988-11-24 | 1988-12-29 | Zambeletti Spa L | Novel compounds |
DE3935371A1 (de) * | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | Stickstoffhaltige ringverbindungen |
GB8830219D0 (en) * | 1988-12-23 | 1989-02-22 | Zambeletti Spa L | Novel compounds |
GB8916395D0 (en) * | 1989-07-18 | 1989-09-06 | Zambeletti Spa L | Pharmaceuticals |
CA2069423A1 (en) * | 1989-11-24 | 1991-05-25 | Roberto Colle | Azacyclic derivatives |
GB8926560D0 (en) * | 1989-11-24 | 1990-01-17 | Zambeletti Spa L | Pharmaceuticals |
US5532243A (en) * | 1992-02-14 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Antipsychotic nitrogen-containing bicyclic compounds |
US5389638A (en) * | 1993-09-10 | 1995-02-14 | Abbott Laboratories | Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors |
TW427978B (en) * | 1996-02-03 | 2001-04-01 | Hoffmann La Roche | Tetrahydroisoquinoline derivatives |
TW436484B (en) * | 1996-04-24 | 2001-05-28 | Dev Center Biotechnology | 1,2,3,4-tetrahydroisoquinoline derivatives having a nitrogen-containing heterocyclic methyl substituent, the preparation process and pharmaceutical composition thereof |
CA2505783A1 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of 4-phenyl-substituted tetrahydroisoquinolines in the treatment of pain, migraine headaches and urinary incontinence |
WO2004050629A2 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence |
AU2003283646A1 (en) * | 2002-12-02 | 2004-06-23 | Pharmacia & Upjohn Company Llc | The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence |
JO3316B1 (ar) | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
TWI725408B (zh) | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2361390A1 (de) * | 1973-12-10 | 1975-06-19 | Merck Patent Gmbh | Isochinolinderivate und verfahren zu ihrer herstellung |
DE2504250A1 (de) * | 1975-02-01 | 1976-08-05 | Merck Patent Gmbh | Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung |
US4232160A (en) * | 1978-10-18 | 1980-11-04 | Miles Laboratories, Inc. | Isoquinoline propionamides exhibiting analgesic properties |
US4518779A (en) * | 1982-09-27 | 1985-05-21 | Pennwalt Corporation | 1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines |
GB8531615D0 (en) * | 1985-12-23 | 1986-02-05 | Zambeletti Spa L | Compounds |
GB8601796D0 (en) * | 1986-01-24 | 1986-02-26 | Zambeletti Spa L | Compounds |
PT89780A (pt) * | 1988-02-23 | 1989-10-04 | Glaxo Group Ltd | Processo para a preparacao de derivados da tetrahidroisoquinolina |
DE3935371A1 (de) * | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | Stickstoffhaltige ringverbindungen |
-
1989
- 1989-02-14 DE DE89301374T patent/DE68910999T2/de not_active Expired - Fee Related
- 1989-02-14 AT AT89301374T patent/ATE97893T1/de not_active IP Right Cessation
- 1989-02-14 ES ES89301374T patent/ES2061972T3/es not_active Expired - Lifetime
- 1989-02-14 EP EP89301374A patent/EP0330360B1/en not_active Expired - Lifetime
- 1989-02-17 AU AU30070/89A patent/AU620845B2/en not_active Ceased
- 1989-02-17 PT PT89746A patent/PT89746B/pt not_active IP Right Cessation
- 1989-02-17 IE IE51989A patent/IE62031B1/en not_active IP Right Cessation
- 1989-02-17 CA CA000591455A patent/CA1333067C/en not_active Expired - Fee Related
- 1989-02-17 DK DK075589A patent/DK75589A/da not_active Application Discontinuation
- 1989-02-17 US US07/312,648 patent/US4954509A/en not_active Expired - Fee Related
- 1989-02-17 NZ NZ228032A patent/NZ228032A/en unknown
- 1989-02-20 JP JP8938504A patent/JPH0219379A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA1333067C (en) | 1994-11-15 |
AU3007089A (en) | 1989-08-24 |
ATE97893T1 (de) | 1993-12-15 |
DK75589A (da) | 1989-08-20 |
DK75589D0 (da) | 1989-02-17 |
AU620845B2 (en) | 1992-02-27 |
DE68910999T2 (de) | 1994-03-24 |
IE890519L (en) | 1989-08-19 |
DE68910999D1 (de) | 1994-01-13 |
PT89746A (pt) | 1989-10-04 |
ES2061972T3 (es) | 1994-12-16 |
EP0330360B1 (en) | 1993-12-01 |
NZ228032A (en) | 1991-12-23 |
EP0330360A1 (en) | 1989-08-30 |
US4954509A (en) | 1990-09-04 |
IE62031B1 (en) | 1994-12-14 |
JPH0219379A (ja) | 1990-01-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19930924 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19970331 |