PT896534E - Formulacoes para injeccao de avermectinas e milbemicinas a base de oleo de ricino - Google Patents
Formulacoes para injeccao de avermectinas e milbemicinas a base de oleo de ricinoInfo
- Publication number
- PT896534E PT896534E PT97916406T PT97916406T PT896534E PT 896534 E PT896534 E PT 896534E PT 97916406 T PT97916406 T PT 97916406T PT 97916406 T PT97916406 T PT 97916406T PT 896534 E PT896534 E PT 896534E
- Authority
- PT
- Portugal
- Prior art keywords
- avermectins
- formulations
- milbemicines
- injection
- pct
- Prior art date
Links
- 239000005660 Abamectin Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 abstract 1
- ZLBGSRMUSVULIE-GSMJGMFJSA-N milbemycin A3 Chemical class O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 ZLBGSRMUSVULIE-GSMJGMFJSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19613972A DE19613972A1 (de) | 1996-04-09 | 1996-04-09 | Injektionsformulierungen von Avermectinen und Milbemycinen auf Basis von Rizinusöl |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT896534E true PT896534E (pt) | 2005-04-29 |
Family
ID=7790774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97916406T PT896534E (pt) | 1996-04-09 | 1997-03-27 | Formulacoes para injeccao de avermectinas e milbemicinas a base de oleo de ricino |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6063394A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0896534B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4257870B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN1095662C (cg-RX-API-DMAC10.html) |
| AT (1) | ATE285233T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU718807B2 (cg-RX-API-DMAC10.html) |
| BR (1) | BR9708540B1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2251087C (cg-RX-API-DMAC10.html) |
| DE (2) | DE19613972A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2235230T3 (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ332224A (cg-RX-API-DMAC10.html) |
| PT (1) | PT896534E (cg-RX-API-DMAC10.html) |
| WO (1) | WO1997037653A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19638045A1 (de) * | 1996-09-18 | 1998-03-19 | Bayer Ag | Injektionsformulierungen von Avermectinen und Milbemycinen |
| HU228617B1 (en) * | 1997-12-03 | 2013-04-29 | Merial Llc | Long acting injectable formulations containing hydrogenated castor oil |
| US6174540B1 (en) | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
| GB9827727D0 (en) * | 1998-12-16 | 1999-02-10 | Pfizer Ltd | Antiparasitic formulations |
| GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
| AU781682B2 (en) * | 2000-03-20 | 2005-06-09 | Zoetis Services Llc | Sustained-release compositions for parenteral administration |
| US20050009762A1 (en) * | 2003-06-06 | 2005-01-13 | Strobel Michael Albert | Application of water and organic solvent soluble ivermectin for topical and oral use |
| CN1275589C (zh) * | 2002-05-31 | 2006-09-20 | 王玉万 | 含抗寄生虫药物的缓释注射剂 |
| US7262214B2 (en) | 2003-02-26 | 2007-08-28 | Merial Limited | 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases |
| US20050271459A1 (en) * | 2004-06-03 | 2005-12-08 | World Wide Stationery Mfg. Co., Ltd. | Interlocking ring tip formations for paired ring members of a ring binder mechanism |
| NZ534939A (en) * | 2004-08-26 | 2007-04-27 | Bomac Research Ltd | Injectable formulation comprising an anthelmintic compound with complexing compound for improved solubility |
| DE102004053964A1 (de) * | 2004-11-09 | 2006-05-11 | Bayer Healthcare Ag | Mittel gegen Demodikose |
| CN101842079B (zh) * | 2007-08-31 | 2012-09-05 | 阿基米德开发有限公司 | 非水性药物组合物 |
| WO2010008891A2 (en) * | 2008-06-24 | 2010-01-21 | Merial Limited | Anthelminthic formulations |
| EP2396006B1 (en) | 2009-02-16 | 2012-12-19 | Pfizer Inc. | High dosage doramectin formulation |
| CN101773467B (zh) * | 2010-01-20 | 2015-09-09 | 北京大北农动物保健科技有限责任公司 | 一种美贝霉素或美贝霉素肟的兽用缓释注射液及制备方法 |
| KR101805087B1 (ko) * | 2010-09-16 | 2017-12-05 | 주식회사 엘지화학 | 높은 방부력을 제공하는 오일 주사 제형 |
| KR20140136005A (ko) * | 2012-03-13 | 2014-11-27 | 바이엘 뉴질랜드 리미티드 | 지속성 조성물 |
| WO2016022066A1 (en) | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| CN119157876A (zh) | 2017-12-15 | 2024-12-20 | 塔苏斯制药有限公司 | 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法 |
| AU2020231319A1 (en) * | 2019-03-01 | 2021-10-21 | Boehringer Ingelheim Animal Health USA Inc. | Injectable clorsulon compositions, methods and uses thereof |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| US11638714B2 (en) | 2020-11-10 | 2023-05-02 | Mountain Valley Md Inc | Water dissolvable macrocyclic lactone cyclodextrin complexes |
| US11077134B1 (en) | 2020-11-10 | 2021-08-03 | Mountain Valley Md Inc | Water dissolvable macrocyclic lactone cyclodextrin complexes |
| US11918572B2 (en) * | 2022-01-28 | 2024-03-05 | Rebel Medicine Inc | Pharmaceutical compositions for treating pain |
| CN114642632A (zh) * | 2022-02-25 | 2022-06-21 | 河北科技大学 | 一种莫西克汀注射液及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4914624A (cg-RX-API-DMAC10.html) * | 1972-06-08 | 1974-02-08 | ||
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| OA06863A (fr) * | 1980-08-04 | 1983-02-28 | Merck & Co Inc | Solubilisation de l'invermectine dans l'eau. |
| NZ210505A (en) * | 1983-12-22 | 1988-06-30 | Merck & Co Inc | Parasiticidal compositions containing avermectin or milbemycin derivatives |
| DE3727648A1 (de) * | 1987-08-19 | 1989-03-02 | Bayer Ag | Neue avermectin derivate, verfahren zu ihrer herstellung und ihre verwendung |
| US5510117A (en) * | 1989-03-09 | 1996-04-23 | Micro-Pak, Inc. | Entrapment vehicle and method |
| ES2052173T3 (es) * | 1989-04-11 | 1994-07-01 | Pfizer | Composiciones inyectables que contienen 25-cyclohexil-avermectina b1. |
| NZ234802A (en) * | 1989-08-14 | 1992-11-25 | Merck & Co Inc | Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals |
| DE69208765T2 (de) * | 1991-07-23 | 1996-09-26 | American Cyanamid Co | Stabile Zusammensetzungen für parenterale Verabrechung und ihre Verwendung |
| ES2131515T3 (es) * | 1991-09-30 | 1999-08-01 | Merck & Co Inc | Formulados inyectables de accion prolongada que contienen aceite de ricino hidrogenado. |
| WO1994008566A1 (en) * | 1992-10-21 | 1994-04-28 | Micro Vesicular Systems, Inc. | Entrapment vehicle and method |
-
1996
- 1996-04-09 DE DE19613972A patent/DE19613972A1/de not_active Withdrawn
-
1997
- 1997-03-27 PT PT97916406T patent/PT896534E/pt unknown
- 1997-03-27 CN CN97193700A patent/CN1095662C/zh not_active Expired - Lifetime
- 1997-03-27 US US09/155,836 patent/US6063394A/en not_active Expired - Lifetime
- 1997-03-27 EP EP97916406A patent/EP0896534B1/de not_active Expired - Lifetime
- 1997-03-27 CA CA002251087A patent/CA2251087C/en not_active Expired - Lifetime
- 1997-03-27 AT AT97916406T patent/ATE285233T1/de active
- 1997-03-27 NZ NZ332224A patent/NZ332224A/en not_active IP Right Cessation
- 1997-03-27 DE DE59712134T patent/DE59712134D1/de not_active Expired - Lifetime
- 1997-03-27 WO PCT/EP1997/001569 patent/WO1997037653A1/de not_active Ceased
- 1997-03-27 BR BRPI9708540-5A patent/BR9708540B1/pt active IP Right Grant
- 1997-03-27 AU AU25066/97A patent/AU718807B2/en not_active Expired
- 1997-03-27 ES ES97916406T patent/ES2235230T3/es not_active Expired - Lifetime
- 1997-03-27 JP JP53579597A patent/JP4257870B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2235230T3 (es) | 2005-07-01 |
| US6063394A (en) | 2000-05-16 |
| AU718807B2 (en) | 2000-04-20 |
| DE59712134D1 (de) | 2005-01-27 |
| JP2000508301A (ja) | 2000-07-04 |
| NZ332224A (en) | 2000-06-23 |
| BR9708540B1 (pt) | 2010-07-27 |
| CA2251087C (en) | 2008-01-15 |
| WO1997037653A1 (de) | 1997-10-16 |
| JP4257870B2 (ja) | 2009-04-22 |
| HK1019404A1 (en) | 2000-02-11 |
| EP0896534B1 (de) | 2004-12-22 |
| BR9708540A (pt) | 1999-08-03 |
| ATE285233T1 (de) | 2005-01-15 |
| DE19613972A1 (de) | 1997-10-16 |
| CN1095662C (zh) | 2002-12-11 |
| CA2251087A1 (en) | 1997-10-16 |
| CN1215331A (zh) | 1999-04-28 |
| AU2506697A (en) | 1997-10-29 |
| EP0896534A1 (de) | 1999-02-17 |
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