PT89363B - Processo para a preparacao de sequencias de dna especificas da malaria, dos seus produtos de expressao e de meios de diagnostico que os contem - Google Patents
Processo para a preparacao de sequencias de dna especificas da malaria, dos seus produtos de expressao e de meios de diagnostico que os contem Download PDFInfo
- Publication number
- PT89363B PT89363B PT89363A PT8936388A PT89363B PT 89363 B PT89363 B PT 89363B PT 89363 A PT89363 A PT 89363A PT 8936388 A PT8936388 A PT 8936388A PT 89363 B PT89363 B PT 89363B
- Authority
- PT
- Portugal
- Prior art keywords
- clone
- amino acid
- malaria
- acid sequence
- nucleotide sequence
- Prior art date
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims description 27
- 201000004792 malaria Diseases 0.000 title claims description 24
- 238000002360 preparation method Methods 0.000 title claims description 12
- 230000008569 process Effects 0.000 title claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 102
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 43
- 241000223960 Plasmodium falciparum Species 0.000 claims abstract description 28
- 239000000427 antigen Substances 0.000 claims abstract description 25
- 102000036639 antigens Human genes 0.000 claims abstract description 25
- 108091007433 antigens Proteins 0.000 claims abstract description 25
- 108020004414 DNA Proteins 0.000 claims description 63
- 238000003780 insertion Methods 0.000 claims description 39
- 230000037431 insertion Effects 0.000 claims description 39
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 32
- 239000002773 nucleotide Substances 0.000 claims description 22
- 125000003729 nucleotide group Chemical group 0.000 claims description 22
- 102000037865 fusion proteins Human genes 0.000 claims description 11
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- FVFVNNKYKYZTJU-UHFFFAOYSA-N 6-chloro-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(Cl)=N1 FVFVNNKYKYZTJU-UHFFFAOYSA-N 0.000 description 1
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- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
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- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 description 1
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- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 230000012173 estrus Effects 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000005188 flotation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
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- 230000002163 immunogen Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
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- 230000002934 lysing effect Effects 0.000 description 1
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- 238000013507 mapping Methods 0.000 description 1
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- 230000036285 pathological change Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000003415 peat Substances 0.000 description 1
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- 239000011886 peripheral blood Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
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- 150000007949 saponins Chemical class 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N serine Chemical group OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
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- 230000001360 synchronised effect Effects 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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- 238000002604 ultrasonography Methods 0.000 description 1
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- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3744495 | 1987-12-30 | ||
| DE3831351A DE3831351A1 (de) | 1987-12-30 | 1988-09-15 | Malaria-spezifische dna-sequenzen, ihre expressionsprodukte und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT89363A PT89363A (pt) | 1989-12-29 |
| PT89363B true PT89363B (pt) | 1993-08-31 |
Family
ID=25863316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT89363A PT89363B (pt) | 1987-12-30 | 1988-12-29 | Processo para a preparacao de sequencias de dna especificas da malaria, dos seus produtos de expressao e de meios de diagnostico que os contem |
Country Status (11)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4041836A1 (de) * | 1990-12-24 | 1992-06-25 | Behringwerke Ag | Protektive plasmodium falciparum hybridproteine, die teilsequenzen der malaria-antigene hrpii und serp enthalten, ihre herstellung und verwendung |
| WO1994003604A1 (en) * | 1992-08-07 | 1994-02-17 | Schering Corporation | PfEMP3 MALARIA ANTIGEN, ANALOGS, ANTIBODIES AND USES THEREOF |
| US6350933B1 (en) * | 1997-01-10 | 2002-02-26 | The Regents Of The University Of California | RG polynucleotides for conferring powdery mildew resistance in plants |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK79985A (da) * | 1984-02-22 | 1985-08-23 | Wellcome Found | Kloning af dna for protozoelle antigener og dets anvendelse |
| EP0309746A1 (de) * | 1987-09-08 | 1989-04-05 | F. Hoffmann-La Roche Ag | Antimalaria-Vakzine |
-
1988
- 1988-09-15 DE DE3831351A patent/DE3831351A1/de not_active Withdrawn
- 1988-12-20 EP EP88121299A patent/EP0322712B1/de not_active Expired - Lifetime
- 1988-12-20 DE DE8888121299T patent/DE3876227D1/de not_active Expired - Fee Related
- 1988-12-20 ES ES88121299T patent/ES2045075T3/es not_active Expired - Lifetime
- 1988-12-28 IL IL8881888A patent/IL88818A/xx not_active IP Right Cessation
- 1988-12-28 YU YU237588A patent/YU48126B/sh unknown
- 1988-12-28 FI FI886001A patent/FI99144C/fi not_active IP Right Cessation
- 1988-12-28 JP JP63335713A patent/JPH022356A/ja active Pending
- 1988-12-29 PT PT89363A patent/PT89363B/pt not_active IP Right Cessation
- 1988-12-29 DK DK727688A patent/DK727688A/da not_active Application Discontinuation
- 1988-12-30 AU AU27619/88A patent/AU625315B2/en not_active Ceased
-
1993
- 1993-02-23 GR GR930400202T patent/GR3007126T3/el unknown
-
1999
- 1999-03-17 JP JP11072817A patent/JPH11318475A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK727688D0 (da) | 1988-12-29 |
| EP0322712A2 (de) | 1989-07-05 |
| DE3876227D1 (de) | 1993-01-07 |
| EP0322712A3 (en) | 1990-05-02 |
| JPH022356A (ja) | 1990-01-08 |
| AU2761988A (en) | 1989-07-06 |
| YU48126B (sh) | 1997-05-28 |
| AU625315B2 (en) | 1992-07-09 |
| FI886001A (fi) | 1989-07-01 |
| IL88818A (en) | 1997-02-18 |
| GR3007126T3 (US07696358-20100413-C00002.png) | 1993-07-30 |
| DE3831351A1 (de) | 1989-07-13 |
| FI99144B (fi) | 1997-06-30 |
| IL88818A0 (en) | 1989-07-31 |
| DK727688A (da) | 1989-07-01 |
| ES2045075T3 (es) | 1994-01-16 |
| EP0322712B1 (de) | 1992-11-25 |
| YU237588A (en) | 1991-06-30 |
| JPH11318475A (ja) | 1999-11-24 |
| FI99144C (fi) | 1997-10-10 |
| PT89363A (pt) | 1989-12-29 |
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