PT874630E - Terapia combinada de um inibidor da topoisomerase ii e um derivado da bis-dioxipiperazina - Google Patents

Terapia combinada de um inibidor da topoisomerase ii e um derivado da bis-dioxipiperazina

Info

Publication number
PT874630E
PT874630E PT97900205T PT97900205T PT874630E PT 874630 E PT874630 E PT 874630E PT 97900205 T PT97900205 T PT 97900205T PT 97900205 T PT97900205 T PT 97900205T PT 874630 E PT874630 E PT 874630E
Authority
PT
Portugal
Prior art keywords
topoisomerase
bis
mammal
dioxipiperazine
inhibitor
Prior art date
Application number
PT97900205T
Other languages
English (en)
Inventor
Maxwell Sehested
Peter Buhl Lensen
Original Assignee
Topotarget Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Topotarget Aps filed Critical Topotarget Aps
Publication of PT874630E publication Critical patent/PT874630E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT97900205T 1996-01-11 1997-01-10 Terapia combinada de um inibidor da topoisomerase ii e um derivado da bis-dioxipiperazina PT874630E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK2296 1996-01-11
US60310596A 1996-02-20 1996-02-20

Publications (1)

Publication Number Publication Date
PT874630E true PT874630E (pt) 2004-01-30

Family

ID=26063143

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97900205T PT874630E (pt) 1996-01-11 1997-01-10 Terapia combinada de um inibidor da topoisomerase ii e um derivado da bis-dioxipiperazina

Country Status (8)

Country Link
EP (1) EP0874630B1 (pt)
AT (1) ATE247468T1 (pt)
AU (1) AU1367797A (pt)
CA (1) CA2242406C (pt)
DE (1) DE69724228T2 (pt)
ES (1) ES2205164T3 (pt)
PT (1) PT874630E (pt)
WO (1) WO1997025044A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4422916B2 (ja) * 1999-03-12 2010-03-03 トポターゲット・アクティーゼルスカブ アントラサイクリン類の事故的溢血の処置
GB0404675D0 (en) 2004-03-02 2004-04-07 Topotarget As Cancer treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8403912D0 (sv) * 1984-07-30 1984-07-30 Pharmacia Ab Lekemedelssats eller -komposition
US5242901A (en) * 1988-01-27 1993-09-07 New York University Reduction of anthracycline induced cardiotoxicity
PT93772A (pt) * 1989-04-17 1991-01-08 Searle & Co Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
GB9024861D0 (en) * 1990-11-15 1991-01-02 Hellmann Kurt Bis-dioxopiperazines for treating liver tumors
GB9115596D0 (en) * 1991-07-12 1991-09-04 Creighton Andrew M Pharmaceutical compositions
US5587382A (en) * 1994-03-28 1996-12-24 Boehringer Mannheim Italia, Spa 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity

Also Published As

Publication number Publication date
ES2205164T3 (es) 2004-05-01
DE69724228T2 (de) 2004-06-09
EP0874630B1 (en) 2003-08-20
EP0874630A1 (en) 1998-11-04
AU1367797A (en) 1997-08-01
CA2242406A1 (en) 1997-07-17
WO1997025044A1 (en) 1997-07-17
CA2242406C (en) 2009-09-08
DE69724228D1 (de) 2003-09-25
ATE247468T1 (de) 2003-09-15

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