PT84932A - Process for preparing immunoglobulin conjugates - Google Patents
Process for preparing immunoglobulin conjugatesInfo
- Publication number
- PT84932A PT84932A PT84932A PT8493287A PT84932A PT 84932 A PT84932 A PT 84932A PT 84932 A PT84932 A PT 84932A PT 8493287 A PT8493287 A PT 8493287A PT 84932 A PT84932 A PT 84932A
- Authority
- PT
- Portugal
- Prior art keywords
- immunoglobulin conjugates
- preparing immunoglobulin
- preparing
- conjugates
- immunoglobulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86718386A | 1986-05-27 | 1986-05-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT84932A true PT84932A (en) | 1987-06-01 |
| PT84932B PT84932B (pt) | 1990-02-08 |
Family
ID=25349292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT84932A PT84932B (pt) | 1986-05-27 | 1987-05-22 | Processo para a preparacao de conjugados de imunoglobulinas |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0247792A3 (pt) |
| JP (1) | JPS62287000A (pt) |
| KR (1) | KR900006908B1 (pt) |
| CN (1) | CN87104430A (pt) |
| AU (1) | AU600727B2 (pt) |
| CA (1) | CA1288896C (pt) |
| DK (1) | DK260687A (pt) |
| HU (1) | HUT44033A (pt) |
| IL (1) | IL82579A0 (pt) |
| NZ (1) | NZ220441A (pt) |
| PT (1) | PT84932B (pt) |
| SU (1) | SU1561825A3 (pt) |
| ZA (1) | ZA873600B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8728856D0 (en) * | 1987-12-10 | 1988-01-27 | Bradwell A R | Tumour-locating agents & method of locating tumours |
| IL89043A0 (en) * | 1988-01-27 | 1989-08-15 | Lilly Co Eli | Antibody conjugates |
| US5006652A (en) * | 1988-08-08 | 1991-04-09 | Eli Lilly And Company | Intermediates for antibody-vinca drug conjugates |
| US5010176A (en) * | 1988-11-10 | 1991-04-23 | Eli Lilly And Company | Antibody-drug conjugates |
| EP0392717A1 (en) * | 1989-04-04 | 1990-10-17 | Eli Lilly And Company | Pharmaceutical formulations containing immunoglobulin conjugates |
| EP0527189A1 (en) * | 1990-04-25 | 1993-02-17 | PHARMACIA & UPJOHN COMPANY | Novel cc-1065 analogs |
| JP2000506494A (ja) * | 1995-10-18 | 2000-05-30 | メルク エンド カンパニー インコーポレーテッド | 良性前立腺過形成の治療に有用な複合体 |
| DE60231868D1 (de) | 2001-04-24 | 2009-05-20 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| WO2003097647A1 (en) | 2002-05-15 | 2003-11-27 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| DK1592457T3 (da) | 2003-01-27 | 2012-10-22 | Endocyte Inc | Folat-vinblastin-konjugat som lægemiddel |
| JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト，インコーポレイテッド | ２価リンカーおよびその結合体 |
| US8044200B2 (en) | 2005-03-16 | 2011-10-25 | Endocyte, Inc. | Synthesis and purification of pteroic acid and conjugates thereof |
| AU2006279304A1 (en) | 2005-08-19 | 2007-02-22 | Endocyte, Inc. | Multi-drug ligand conjugates |
| EP2382995A3 (en) | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Ligand conjugates of Vinca alkaloids, analogs and derivatives |
| WO2008101231A2 (en) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| WO2008112873A2 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| BR112015008365A2 (pt) | 2012-10-16 | 2017-07-04 | Endocyte Inc | composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente |
| CN108948128B (zh) * | 2018-07-02 | 2021-10-01 | 中国科学技术大学 | 一种基于缺电子苯甲醛的无催化剂腙连接多肽或蛋白质化学修饰方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI820020L (fi) * | 1981-01-12 | 1982-07-13 | Lilly Industries Ltd | Immunoglobulinkonjugater |
| GB2137210B (en) * | 1983-03-30 | 1986-11-19 | Lilly Industries Ltd | Immunoglobulin conjugates |
| US4675400A (en) * | 1985-06-17 | 1987-06-23 | Eli Lilly And Company | Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids |
| ATE89567T1 (de) * | 1985-11-12 | 1993-06-15 | Wallone Region | Konjugate von vinblastin und seine derivate, verfahren zur herstellung derselben und diese konjugate enthaltende pharmazeutische zusammensetzungen. |
-
1987
- 1987-05-19 IL IL82579A patent/IL82579A0/xx unknown
- 1987-05-19 ZA ZA873600A patent/ZA873600B/xx unknown
- 1987-05-20 CA CA000537474A patent/CA1288896C/en not_active Expired - Lifetime
- 1987-05-21 EP EP87304516A patent/EP0247792A3/en not_active Withdrawn
- 1987-05-22 PT PT84932A patent/PT84932B/pt not_active IP Right Cessation
- 1987-05-22 SU SU874202656A patent/SU1561825A3/ru active
- 1987-05-22 DK DK260687A patent/DK260687A/da not_active Application Discontinuation
- 1987-05-25 AU AU73349/87A patent/AU600727B2/en not_active Ceased
- 1987-05-25 KR KR1019870005156A patent/KR900006908B1/ko not_active IP Right Cessation
- 1987-05-26 CN CN198787104430A patent/CN87104430A/zh active Pending
- 1987-05-26 NZ NZ220441A patent/NZ220441A/xx unknown
- 1987-05-26 HU HU872417A patent/HUT44033A/hu unknown
- 1987-05-26 JP JP62129573A patent/JPS62287000A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SU1561825A3 (ru) | 1990-04-30 |
| CA1288896C (en) | 1991-09-10 |
| KR900006908B1 (ko) | 1990-09-24 |
| DK260687A (da) | 1987-11-28 |
| CN87104430A (zh) | 1988-05-11 |
| KR870011132A (ko) | 1987-12-21 |
| DK260687D0 (da) | 1987-05-22 |
| AU7334987A (en) | 1987-12-03 |
| JPS62287000A (ja) | 1987-12-12 |
| PT84932B (pt) | 1990-02-08 |
| NZ220441A (en) | 1989-09-27 |
| EP0247792A2 (en) | 1987-12-02 |
| ZA873600B (en) | 1988-12-28 |
| IL82579A0 (en) | 1987-11-30 |
| EP0247792A3 (en) | 1989-07-12 |
| HUT44033A (en) | 1988-01-28 |
| AU600727B2 (en) | 1990-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19920120 |