PT84415B - Processo de purificacao de alfa-1-antiprotease - Google Patents

Processo de purificacao de alfa-1-antiprotease

Info

Publication number
PT84415B
PT84415B PT84415A PT8441587A PT84415B PT 84415 B PT84415 B PT 84415B PT 84415 A PT84415 A PT 84415A PT 8441587 A PT8441587 A PT 8441587A PT 84415 B PT84415 B PT 84415B
Authority
PT
Portugal
Prior art keywords
antiprotease
alpha
purification process
purification
antiprotease purification
Prior art date
Application number
PT84415A
Other languages
English (en)
Other versions
PT84415A (en
Inventor
Alex Joseph Bollen
Paul Chuchana
Marc Hoylaerts
Original Assignee
Smithkline Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Biolog filed Critical Smithkline Biolog
Publication of PT84415A publication Critical patent/PT84415A/pt
Publication of PT84415B publication Critical patent/PT84415B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
PT84415A 1986-03-07 1987-03-05 Processo de purificacao de alfa-1-antiprotease PT84415B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/836,868 US4629567A (en) 1986-03-07 1986-03-07 Alpha-1-antiprotease purification

Publications (2)

Publication Number Publication Date
PT84415A PT84415A (en) 1987-04-01
PT84415B true PT84415B (pt) 1989-10-04

Family

ID=25272922

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84415A PT84415B (pt) 1986-03-07 1987-03-05 Processo de purificacao de alfa-1-antiprotease

Country Status (7)

Country Link
US (1) US4629567A (pt)
EP (1) EP0237515A3 (pt)
JP (1) JPS62223197A (pt)
AU (1) AU589337B2 (pt)
DK (1) DK112387A (pt)
PT (1) PT84415B (pt)
ZA (1) ZA871634B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4697003A (en) * 1985-11-01 1987-09-29 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
NZ218148A (en) * 1985-11-08 1989-06-28 Smithkline Beckman Corp E.coli expression vector coding for alpha-1-antitrypsin
US5059329A (en) * 1989-09-19 1991-10-22 Thymax Corporation Method for isolating dithiochrome, an insulin-binding molecule with glucose metabolism-related pharmaceutical utility
JP2832848B2 (ja) * 1989-10-21 1998-12-09 株式会社林原生物化学研究所 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途
FR2711371B1 (fr) * 1993-10-18 1995-12-29 Aetsrn Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu.
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
EP0871671A1 (en) 1995-09-07 1998-10-21 PPL Therapeutics (Scotland) Limited Purification of alpha-1 proteinase inhibitor
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
WO2000051625A1 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
WO2000051624A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Methods and compositions useful in inhibiting apoptosis
US6462180B1 (en) 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
CA2432641A1 (en) 2000-12-14 2002-06-20 Bayer Corporation Method of preparing alpha-1 proteinase inhibitor
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
AU2015200572B2 (en) * 2002-12-31 2016-06-02 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
WO2004072647A1 (en) * 2003-02-07 2004-08-26 Beyond Genomics Removal of proteins from a sample
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
UA86775C2 (ru) * 2003-08-12 2009-05-25 Октафарма Аг Способ очистки раствора альфа-1-антитрипсина
US7850970B2 (en) 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
ES2305845T5 (es) * 2003-09-22 2012-04-12 Kamada Ltd. Preparación a gran escala de un inhibidor de proteinasa alfa-1 y su utilización
US7807435B2 (en) * 2005-08-11 2010-10-05 Baxter International Inc. Method for the purification of alpha-1 proteinase inhibitor (a1PI)
GB0524432D0 (en) * 2005-11-30 2006-01-11 Nhs Blood & Transplant Method
US20080124303A1 (en) * 2005-12-12 2008-05-29 Cavit Sciences, Inc Methods and compositions for treatment of viral infections
EP1999262B1 (en) * 2006-03-30 2012-09-26 Baxter International Inc. Process for the purification of recombinant alpha 1-antitrypsin involving a step of anion exchange chromatography
WO2009025754A2 (en) 2007-08-17 2009-02-26 Csl Behring Gmbh Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i
EP2723370A4 (en) 2011-06-24 2015-06-03 Univ Colorado Regents COMPOSITIONS, PROCESS AND USE OF ALPHA-1-ANTITRYPHIN FUSION MOLECULES
KR20140137347A (ko) 2012-01-10 2014-12-02 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
CA2943938A1 (en) 2013-03-29 2014-10-02 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for preparing a subject for organ or non-organ implantation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3808124A (en) * 1972-04-14 1974-04-30 American Cyanamid Co Purification of human plasminogen
US4264449A (en) * 1977-09-21 1981-04-28 American National Red Cross Antibody-specific solid phase immunoadsorbent, preparation thereof, and antibody purification therewith
US4205130A (en) * 1979-03-12 1980-05-27 Pirkko Vihko Method of purification of human prostatic acid phosphatase
SE8302483L (sv) * 1983-05-02 1984-11-03 Pharmacia Ind Forfarande vid rening av biologiskt aktiva substanser
US4525465A (en) * 1983-10-07 1985-06-25 Nippon Kayaku Kabushiki Kaisha Water-insoluble biospecific absorbent containing argininal derivative
US4697003A (en) * 1985-11-01 1987-09-29 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III

Also Published As

Publication number Publication date
EP0237515A2 (fr) 1987-09-16
PT84415A (en) 1987-04-01
ZA871634B (en) 1988-01-27
JPS62223197A (ja) 1987-10-01
DK112387A (da) 1987-09-08
AU6974187A (en) 1987-09-10
AU589337B2 (en) 1989-10-05
DK112387D0 (da) 1987-03-04
EP0237515A3 (fr) 1989-03-01
US4629567A (en) 1986-12-16

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Legal Events

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MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19910913