PT81662B - Process for the preparation of novel piperidine derivatives - Google Patents

Process for the preparation of novel piperidine derivatives

Info

Publication number
PT81662B
PT81662B PT8166285A PT8166285A PT81662B PT 81662 B PT81662 B PT 81662B PT 8166285 A PT8166285 A PT 8166285A PT 8166285 A PT8166285 A PT 8166285A PT 81662 B PT81662 B PT 81662B
Authority
PT
Portugal
Prior art keywords
preparation
piperidine derivatives
novel piperidine
novel
derivatives
Prior art date
Application number
PT8166285A
Other languages
English (en)
Portuguese (pt)
Other versions
PT81662A (en
Inventor
Roger Thomas Martin
David Miller
Jean Anne Stemp
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848431478A external-priority patent/GB8431478D0/en
Priority claimed from GB858520619A external-priority patent/GB8520619D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of PT81662A publication Critical patent/PT81662A/pt
Publication of PT81662B publication Critical patent/PT81662B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
PT8166285A 1984-12-13 1985-12-12 Process for the preparation of novel piperidine derivatives PT81662B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848431478A GB8431478D0 (en) 1984-12-13 1984-12-13 Compounds
GB858520619A GB8520619D0 (en) 1985-08-16 1985-08-16 Compounds

Publications (2)

Publication Number Publication Date
PT81662A PT81662A (en) 1986-01-01
PT81662B true PT81662B (en) 1987-10-09

Family

ID=26288569

Family Applications (1)

Application Number Title Priority Date Filing Date
PT8166285A PT81662B (en) 1984-12-13 1985-12-12 Process for the preparation of novel piperidine derivatives

Country Status (5)

Country Link
EP (1) EP0190496A3 (OSRAM)
AU (1) AU5111485A (OSRAM)
DK (1) DK574685A (OSRAM)
GR (1) GR853000B (OSRAM)
PT (1) PT81662B (OSRAM)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
DK231088D0 (da) * 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
GB8714707D0 (en) * 1987-06-23 1987-07-29 Beecham Group Plc Chemical process
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi
US5169855A (en) * 1990-03-28 1992-12-08 Du Pont Merck Pharmaceutical Company Piperidine ether derivatives as psychotropic drugs or plant fungicides
IL98757A (en) * 1990-07-18 1997-01-10 Novo Nordisk As Piperidine derivatives their preparation and pharmaceutical compositions containing them
ES2102295B1 (es) * 1994-03-18 1998-04-01 Ferrer Int Nuevos compuestos derivados de la n-benzoilmetil-piperidina.
US5856493A (en) * 1995-02-06 1999-01-05 Smithkline Beecham Corporation Process for making novel form of paroxeting hydrochloride anhydrate
GB9526645D0 (en) * 1995-12-28 1996-02-28 Chiroscience Ltd Stereoselective synthesis
ES2121684B1 (es) * 1996-03-15 1999-08-16 Vita Invest Sa Procedimiento para la obtencion de (+)-cis / (+)-trans-4-(4-fluorofenil)-1-metilpiperidina-3-carboxilato de etilo.
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
ES2331937T3 (es) 1996-06-13 2010-01-20 Sumitomo Chemical Company, Limited Derivados de piperidina como intermediarios para la preparacion de paroxetina y procedimiento de preparacion de los mismos.
HU221921B1 (hu) 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
TR199902929T2 (xx) * 1997-05-29 2000-06-21 Smithkline Beecham Corporation Yeni proses.
AU2002301956B2 (en) * 1997-06-10 2006-02-09 Synthon B.V. 4-phenylpiperidine compounds
TR200201156T2 (tr) * 1997-06-10 2002-07-22 Synthon B.V. 4-Fenilpiperidin bileşimleri.
ES2149687B1 (es) * 1998-04-08 2001-05-16 Medichem Sa Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
EP1140832A4 (en) * 1998-12-22 2004-11-03 Pentech Pharmaceuticals Inc PROCESS FOR THE PREPARATION OF INTERMEDIATES AND DERIVATIVES OF ARYLPIPERIDINE CARBINOL
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9916187D0 (en) * 1999-07-09 1999-09-08 Smithkline Beecham Plc Novel process
IT1313702B1 (it) * 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
PT1286965E (pt) * 2000-05-12 2004-04-30 Synthon Bv Compostos de piperidina e processo para a sua producao
AU2000246280A1 (en) * 2000-05-12 2001-11-20 Synthon B.V. Tosylate salts of 4-(p-fluorophenyl)-piperidine-3-carbinols
US7517892B2 (en) * 2000-09-11 2009-04-14 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof
NL1017421C2 (nl) 2001-02-21 2002-01-15 Synthon Bv Werkwijze voor het vervaardigen van paroxetine.
US20030032809A1 (en) * 2001-04-25 2003-02-13 Subhash P. Upadhyaya Optimized procedures for the manufacture of paroxetine salts
US6956121B2 (en) * 2002-03-01 2005-10-18 Teva Pharmaceutical Industries Ltd. Preparation of paroxetine involving novel intermediates
JP2006507363A (ja) * 2002-11-01 2006-03-02 ニューロサーチ、アクティーゼルスカブ 新規ピペリジン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
WO2004043921A1 (en) * 2002-11-11 2004-05-27 Natco Pharma Limited Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines.
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives
JP5038392B2 (ja) * 2006-04-03 2012-10-03 エフ．ホフマン−ラ ロシュ アーゲー 鏡像異性的に富化した環式β−アリール又はヘテロアリールカルボン酸の調製方法
PL2358675T3 (pl) 2008-11-14 2013-03-29 Theravance Inc Związki 4-[2-(2-Fluorofenoksymetylo)fenylo]piperydyny
US8778949B2 (en) 2010-01-11 2014-07-15 Theravance Biopharma R&D Ip, Llc 1-(2-phenoxymethylphenyl)piperazine compounds
ES2543064T3 (es) 2010-03-22 2015-08-14 Theravance Biopharma R&D Ip, Llc Compuestos de 1-(2-fenoximetilheteroaril)piperidina y piperazina
CN111533682B (zh) * 2020-05-29 2022-03-01 清华大学 帕罗西汀及其类似物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds

Also Published As

Publication number Publication date
DK574685A (da) 1986-06-14
GR853000B (OSRAM) 1986-04-16
EP0190496A2 (en) 1986-08-13
AU5111485A (en) 1986-06-19
DK574685D0 (da) 1985-12-11
EP0190496A3 (en) 1987-05-27
PT81662A (en) 1986-01-01

Similar Documents

Publication Publication Date Title
PT81662B (en) Process for the preparation of novel piperidine derivatives
PT83608A (en) Process for the preparation of paroxetine derivatives
PT81000A (en) Process for the preparation of heterocyclic derivatives
PT82890A (en) Process for the preparation of novel n-aralkyl piperidinemethanol derivatives
EP0165537A3 (en) Process for the preparation of heteroaryloxyacetamides
PT80270A (en) Process for preparing 9a-aza-9a-homoerytromycin of derivatives
PT80178B (en) Process for the preparation of substituted alpha-amino-acids
HU896499D0 (en) Process for the preparation of piperidine derivatives
PT79818B (en) Process for the preparation of alpha-acetylamin-ergolines
HRP921043B1 (en) Process for the preparation of hydroxy-4-2h-1-benzothiopyrane-2-ones
PT80919A (en) Process for the preparation of 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1h-indoles
PT81526A (en) Process for the preparation of new homopropargylamines
YU43689B (en) Process for preparing derivatives of silibinine
YU7685A (en) Process for obtaining derivatives of dihydropyridine
GB2158824B (en) Process for the preparation of 2-amino-s-triazines
DE3566249D1 (en) Process for the preparation of fluoroformiates
DE3570653D1 (en) Process for the preparation of beta-aminoethylketones
DE3476069D1 (en) Improved process for the preparation of polyhydroxybutadienes
PT80634A (en) Process for the preparation of naftoxazines
DE3560035D1 (en) Process for the preparation of 2-methyl-2-alkenals
PT82873A (en) Process for the preparation of novel secocanthine derivatives
EP0173202A3 (en) Process for the preparation of chloro-o-nitroanilines
EP0175364A3 (en) Process for the preparation of alpha-beta-diaminoacrylnitriles
DE3571805D1 (en) Process for the preparation of benzene derivatives
EP0166214A3 (en) Process for the preparation of dialkylsuccinylsuccinat