PT816340E - Processo para a preparacao de derivados de 4-(2-(2-piridil)etoxi)benzaldeido - Google Patents
Processo para a preparacao de derivados de 4-(2-(2-piridil)etoxi)benzaldeidoInfo
- Publication number
- PT816340E PT816340E PT97304554T PT97304554T PT816340E PT 816340 E PT816340 E PT 816340E PT 97304554 T PT97304554 T PT 97304554T PT 97304554 T PT97304554 T PT 97304554T PT 816340 E PT816340 E PT 816340E
- Authority
- PT
- Portugal
- Prior art keywords
- chem
- formula
- compound represented
- pyridyl
- ethoxy
- Prior art date
Links
- RPCKLKUHBCNVQX-UHFFFAOYSA-N 4-(2-pyridin-2-ylethoxy)benzaldehyde Chemical class C1=CC(C=O)=CC=C1OCCC1=CC=CC=N1 RPCKLKUHBCNVQX-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- -1 alkaline earth metal carbonate Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 150000001467 thiazolidinediones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16786296 | 1996-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT816340E true PT816340E (pt) | 2003-08-29 |
Family
ID=15857471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97304554T PT816340E (pt) | 1996-06-27 | 1997-06-26 | Processo para a preparacao de derivados de 4-(2-(2-piridil)etoxi)benzaldeido |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5952509A (pt) |
| EP (1) | EP0816340B1 (pt) |
| AT (1) | ATE238282T1 (pt) |
| CA (1) | CA2208878C (pt) |
| CY (1) | CY2393B1 (pt) |
| DE (1) | DE69721134T2 (pt) |
| DK (1) | DK0816340T3 (pt) |
| ES (1) | ES2191811T3 (pt) |
| PT (1) | PT816340E (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
| DZ2937A1 (fr) * | 1998-11-12 | 2004-03-15 | Smithkline Beecham Plc | Compositions nouvelles de sensibilidants à l'insuline. |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| WO2002028857A1 (en) * | 2000-10-05 | 2002-04-11 | Dr. Reddy's Research Foundation | Polymorphs of pioglitazone hydrochloride and their use as antidiabetics |
| FR2820742B1 (fr) * | 2001-02-14 | 2005-03-11 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| RU2281285C2 (ru) | 2001-04-26 | 2006-08-10 | Зентива А.С. | Способ получения пиоглитазона в качестве противодиабетического средства |
| WO2003026586A2 (en) * | 2001-09-28 | 2003-04-03 | Teva Pharmaceutical Industries Ltd. | Pioglitazone hydrochloride |
| US20050187258A1 (en) * | 2001-12-20 | 2005-08-25 | Ben-Zion Dolitzky | Hydrogenation of precursors to thiazolidinedione antihyperglycemics |
| US6992191B2 (en) * | 2001-12-20 | 2006-01-31 | Teva Pharmaceutical Industries, Ltd. | Hydrogenation of precursors to thiazolidinedione antihyperglycemics |
| EP1474417B1 (en) * | 2002-04-29 | 2006-03-22 | Teva Pharmaceutical Industries Ltd. | Processes for preparing losartan and losartan potassium |
| TR200302265T1 (tr) * | 2002-06-19 | 2004-08-23 | Eös Eczacibaşi Özgün Ki̇myasal Ürünler San. Ve Ti̇c. A.Ş. | Sübstitiye fenil eterlerin üretimi için proses |
| US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| WO2004024059A2 (en) * | 2002-09-12 | 2004-03-25 | Themis Laboratories Private Limited, | Improved process for preparation of thiazolidinedione derivatives |
| TW200517127A (en) * | 2003-08-07 | 2005-06-01 | Sb Pharmco Inc | Novel composition |
| GB0318824D0 (en) * | 2003-08-11 | 2003-09-10 | Glaxo Group Ltd | Novel composition |
| WO2005021542A2 (en) * | 2003-08-28 | 2005-03-10 | Ranbaxy Laboratories Limited | Process for the preparation of pioglitazone |
| GB0325174D0 (en) * | 2003-10-28 | 2003-12-03 | Sandoz Ag | Organic compounds |
| HUP0304096A2 (hu) * | 2003-12-19 | 2005-08-29 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás pioglitazon hidrogénklorid előállítására és intermedierjei |
| CA2566352A1 (en) * | 2004-05-12 | 2005-11-17 | Medichem S.A. | Process for the preparation of rosiglitazone |
| EA013161B1 (ru) * | 2005-06-08 | 2010-02-26 | Орион Корпорейшн | Дозированная форма для перорального применения |
| US20080182880A1 (en) * | 2006-09-28 | 2008-07-31 | Mailatur Sivaraman Mohan | Pioglitazone composition |
| TW200914006A (en) * | 2007-07-12 | 2009-04-01 | Takeda Pharmaceutical | Coated preparation |
| WO2012153312A1 (en) | 2011-05-11 | 2012-11-15 | Ranbaxy Laboratories Limited | Process for the purification of pioglitazone |
| MX2016012687A (es) | 2014-04-02 | 2017-04-27 | Minoryx Therapeutics S L | Derivados de 2,4-tiazolidindiona en el tratamiento de trastornos del sistema nervioso central. |
| CN110022877B (zh) | 2016-12-01 | 2023-06-23 | 米尼奥尔克斯治疗有限公司 | 用于治疗非酒精性脂肪性肝病的5-[[4-[2-[5-(1-羟基乙基)吡啶-2-基]乙氧基]苯基]甲基]-1,3-噻唑烷-2,4-二酮 |
| US11124505B2 (en) | 2016-12-23 | 2021-09-21 | Minoryx Therapeutics S.L. | Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione and salts thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| ATE123278T1 (de) * | 1991-03-25 | 1995-06-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von ethern. |
| WO1992018501A1 (en) * | 1991-04-11 | 1992-10-29 | The Upjohn Company | Thiazolidinedione derivatives, production and use thereof |
-
1997
- 1997-06-23 US US08/880,638 patent/US5952509A/en not_active Expired - Lifetime
- 1997-06-26 EP EP97304554A patent/EP0816340B1/en not_active Expired - Lifetime
- 1997-06-26 DE DE69721134T patent/DE69721134T2/de not_active Expired - Lifetime
- 1997-06-26 PT PT97304554T patent/PT816340E/pt unknown
- 1997-06-26 AT AT97304554T patent/ATE238282T1/de active
- 1997-06-26 CA CA002208878A patent/CA2208878C/en not_active Expired - Lifetime
- 1997-06-26 DK DK97304554T patent/DK0816340T3/da active
- 1997-06-26 ES ES97304554T patent/ES2191811T3/es not_active Expired - Lifetime
-
1999
- 1999-04-12 US US09/292,384 patent/US6100403A/en not_active Expired - Lifetime
-
2003
- 2003-11-28 CY CY0300088A patent/CY2393B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE238282T1 (de) | 2003-05-15 |
| DE69721134T2 (de) | 2004-03-04 |
| US6100403A (en) | 2000-08-08 |
| CA2208878A1 (en) | 1997-12-27 |
| DE69721134D1 (de) | 2003-05-28 |
| US5952509A (en) | 1999-09-14 |
| ES2191811T3 (es) | 2003-09-16 |
| EP0816340B1 (en) | 2003-04-23 |
| CY2393B1 (en) | 2004-09-10 |
| CA2208878C (en) | 2002-08-20 |
| EP0816340A1 (en) | 1998-01-07 |
| DK0816340T3 (da) | 2003-07-14 |
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