PT80107A - Process for the preparation of substituted derivatives of tetrahydropyrimidine and imidazoline - Google Patents
Process for the preparation of substituted derivatives of tetrahydropyrimidine and imidazolineInfo
- Publication number
- PT80107A PT80107A PT8010785A PT8010785A PT80107A PT 80107 A PT80107 A PT 80107A PT 8010785 A PT8010785 A PT 8010785A PT 8010785 A PT8010785 A PT 8010785A PT 80107 A PT80107 A PT 80107A
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- tetrahydropyrimidine
- imidazoline
- preparation
- substituted derivatives
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
(1) Tetrahydropyrimidine and imidazoline derivs. of formula (I) and their acid-addn. salts are new. X = O or S; R1 = H or 1-3C alkyl; R2 = H, 1-6C alkyl, CHR16-(2-6C)alkenyl, (CR16R16)mR15 or CHR16-CH=CHPh; R15 = OH or Ph; R16 = H, Me or Et; m = 2,3 or 4 or when R15 = Ph, also 1; R4-R9 = H or any 1 or 2 are 1-3C alkyl; n = 0 or 1; R10 = H, 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, 1-4C alkylsulphinyl, halogen or CF3; R11 = H, 1-3C alkyl or halogen; R12 = H, Me or Et. Provided that (a) when R10 = H 4-Br or 4-Me, R11 = R12 = H, X = O and n = 0, then at least 1 or R1, R2, R4, R5, R8 and R9 is other than H; (b) when R10 = R11 = R12 = H or R10 = 3-Cl, R11 = 4-Cl, R12 = H, X = O and n = 1, then at least 1 or R1, R2, R4-R9 is other than H; (c) when R10 = H or 4-Cl, R11 = R12 = H, R2 = Me and X = O, then at least 1 or R1, R4, R5, R8 and R9 and when n = 1, R6 and R7 is other than H; and (d) when R10 = H, 4-MeO or 4-Me, R11 = R12 = H, R2 = Me, X = S and n = 1, then at least 1 of R1 and R4-R9 is other than H. (2) The use as pharmaceuticals of (I) as defined above, and without the limitations of paragraphs (a)-(d), is new.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59013784A | 1984-03-16 | 1984-03-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT80107A true PT80107A (en) | 1985-04-01 |
PT80107B PT80107B (en) | 1987-03-24 |
Family
ID=24361014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT8010785A PT80107B (en) | 1984-03-16 | 1985-03-14 | Process for the preparation of substituted derivatives of tetrahydropyrimidine and imidazoline |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS60209571A (en) |
AU (1) | AU3989085A (en) |
DK (1) | DK117785D0 (en) |
FI (1) | FI851055L (en) |
GR (1) | GR850653B (en) |
IL (1) | IL74605A0 (en) |
PT (1) | PT80107B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69723267T2 (en) * | 1996-04-25 | 2004-04-22 | Nissan Chemical Industries, Ltd. | ETHYLENE DERIVATIVES AND PESTICIDES |
KR20010108050A (en) | 1998-12-25 | 2001-12-07 | 도쿠시마 히데이치 | Acrylonitrile compounds |
-
1985
- 1985-03-14 IL IL74605A patent/IL74605A0/en unknown
- 1985-03-14 DK DK117785A patent/DK117785D0/en not_active Application Discontinuation
- 1985-03-14 PT PT8010785A patent/PT80107B/en unknown
- 1985-03-14 GR GR850653A patent/GR850653B/el unknown
- 1985-03-15 FI FI851055A patent/FI851055L/en not_active Application Discontinuation
- 1985-03-15 JP JP60050670A patent/JPS60209571A/en active Pending
- 1985-03-15 AU AU39890/85A patent/AU3989085A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPS60209571A (en) | 1985-10-22 |
PT80107B (en) | 1987-03-24 |
FI851055L (en) | 1985-09-17 |
GR850653B (en) | 1985-07-16 |
FI851055A0 (en) | 1985-03-15 |
AU3989085A (en) | 1985-09-19 |
DK117785D0 (en) | 1985-03-14 |
IL74605A0 (en) | 1985-06-30 |
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