PT77034A - Process for the preparation of a phenylalkylaminoethylsalicylamide - Google Patents

Process for the preparation of a phenylalkylaminoethylsalicylamide

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Publication number
PT77034A
PT77034A PT7703483A PT7703483A PT77034A PT 77034 A PT77034 A PT 77034A PT 7703483 A PT7703483 A PT 7703483A PT 7703483 A PT7703483 A PT 7703483A PT 77034 A PT77034 A PT 77034A
Authority
PT
Portugal
Prior art keywords
aryl
prepn
glycyl
phenylpropyl
esp
Prior art date
Application number
PT7703483A
Other languages
Portuguese (pt)
Other versions
PT77034B (en
Inventor
Elijah H Gold
Esther Babad
Lydia Peer
Wei K Chang
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to PT7703483A priority Critical patent/PT77034B/en
Publication of PT77034A publication Critical patent/PT77034A/en
Publication of PT77034B publication Critical patent/PT77034B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Prepn. of (-)-5-((R)-1-hydroxy 2-((R)-1-methyl-3-phenylpropyl) aminoethyl)salicylamide (I) or its acid-addn. salts includes the redn. of the glycyl carbonyl function of a 2-(opt. protected OH)-5-(N-protected-N-((R) 1-methyl-3-phenylpropyl) glycyl)benzamide (II). The N-protecting gp. is a (R)-ArCHY-qp. (Ar is aryl esp. aryl having a single benzene ring; and Y is 1-6C alkyl) esp. (R)-alpha-methylbenzyl go. Intermediates of formula (IIa) are new. (Ar is aryl: Y is 1-6C alkyl; Z is H or 3-(H2NOC)-4-(P'O)C6H3X-CH2; p' is a protecting gp. removable by hydrogenolysis; and X is CO or (R1S)CH(OH)). (I) is one of the 4 optically active stereoisomers found in the antihypertensive agent labetalol described in US4012444, and (I) and its prepn. are described in EP--9702. By using the stereospecific intermediates (II), which can be obtd. by resolution through salt formation, without the need for chromatographic sepns. etc.
PT7703483A 1983-07-15 1983-07-15 Process for the preparation of a phenylalkylaminoethylsalicylamide PT77034B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PT7703483A PT77034B (en) 1983-07-15 1983-07-15 Process for the preparation of a phenylalkylaminoethylsalicylamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT7703483A PT77034B (en) 1983-07-15 1983-07-15 Process for the preparation of a phenylalkylaminoethylsalicylamide

Publications (2)

Publication Number Publication Date
PT77034A true PT77034A (en) 1983-08-01
PT77034B PT77034B (en) 1986-01-28

Family

ID=20083337

Family Applications (1)

Application Number Title Priority Date Filing Date
PT7703483A PT77034B (en) 1983-07-15 1983-07-15 Process for the preparation of a phenylalkylaminoethylsalicylamide

Country Status (1)

Country Link
PT (1) PT77034B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113698316A (en) * 2021-09-03 2021-11-26 安徽美致诚药业有限公司 Preparation method of labetalol hydrochloride

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113698316A (en) * 2021-09-03 2021-11-26 安徽美致诚药业有限公司 Preparation method of labetalol hydrochloride
CN113698316B (en) * 2021-09-03 2022-04-19 安徽美致诚药业有限公司 Preparation method of labetalol hydrochloride

Also Published As

Publication number Publication date
PT77034B (en) 1986-01-28

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