PT76238A - Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxiyacetic acid - Google Patents

Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxiyacetic acid

Info

Publication number
PT76238A
PT76238A PT76238A PT7623883A PT76238A PT 76238 A PT76238 A PT 76238A PT 76238 A PT76238 A PT 76238A PT 7623883 A PT7623883 A PT 7623883A PT 76238 A PT76238 A PT 76238A
Authority
PT
Portugal
Prior art keywords
acid
methoxy
methyl
preparation
indoleacetoxiyacetic
Prior art date
Application number
PT76238A
Other languages
Portuguese (pt)
Original Assignee
Troponwerke Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke Gmbh & Co Kg filed Critical Troponwerke Gmbh & Co Kg
Publication of PT76238A publication Critical patent/PT76238A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Process for the preparation of 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3- indoleacetoxyacetic acid, characterised in that the derivative of indolecarboxylic acid of the formula see diagramm : EP0087657,P4,F1 is reacted with compounds of the formula see diagramm : EP0087657,P4,F2 in which R**2 represents hydrogen or ammonium, in the presence of inert organic solvents under absolutely anhydrous conditions in a temperature range of -10 to 80 degrees C.
PT76238A 1982-02-26 1983-02-16 Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxiyacetic acid PT76238A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823206887 DE3206887A1 (en) 1982-02-26 1982-02-26 METHOD FOR THE PRODUCTION OF 1- (4-CHLOROBENZOYL) -5-METHOXY-2-METHYL-3-INDOLACETOXYACETIC ACID

Publications (1)

Publication Number Publication Date
PT76238A true PT76238A (en) 1983-03-01

Family

ID=6156732

Family Applications (1)

Application Number Title Priority Date Filing Date
PT76238A PT76238A (en) 1982-02-26 1983-02-16 Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxiyacetic acid

Country Status (7)

Country Link
EP (1) EP0087657B1 (en)
JP (1) JPS58164572A (en)
AT (1) ATE19774T1 (en)
DE (2) DE3206887A1 (en)
ES (1) ES8401465A1 (en)
GR (1) GR78118B (en)
PT (1) PT76238A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443993A1 (en) * 1984-12-01 1986-06-05 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING NEW INDOLDER DERIVATIVES AND THE USE THEREOF

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS190723B1 (en) * 1976-06-30 1979-06-29 Ludmila Fisnerova 2-phenyl-2-carboxyethylester of 1-/p-chlorbenzoyl/-5-methoxy-2-methyl-3-indolyl acetic acid and method of producing the same
DE2735537A1 (en) * 1977-08-06 1979-02-22 Troponwerke Gmbh & Co Kg INDOLACETOXYACETYLAMINO ACID DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND USE AS A MEDICINAL PRODUCT
DE2740854A1 (en) * 1977-09-10 1979-03-29 Troponwerke Gmbh & Co Kg Substd. 3-indole-acetoxy-alkane sulphonic acid salts - useful as antiphlogistic and anti-hypotonic agents

Also Published As

Publication number Publication date
JPH0254826B2 (en) 1990-11-22
DE3363466D1 (en) 1986-06-19
ES520122A0 (en) 1983-12-16
EP0087657A1 (en) 1983-09-07
GR78118B (en) 1984-09-26
ATE19774T1 (en) 1986-05-15
EP0087657B1 (en) 1986-05-14
DE3206887A1 (en) 1983-09-15
JPS58164572A (en) 1983-09-29
ES8401465A1 (en) 1983-12-16

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