DE2735537A1 - Indolacetoxyacetylaminosaeurederivate, methods for their manufacture and their use as medicines - Google Patents

Indolacetoxyacetylaminosaeurederivate, methods for their manufacture and their use as medicines

Info

Publication number
DE2735537A1
DE2735537A1 DE19772735537 DE2735537A DE2735537A1 DE 2735537 A1 DE2735537 A1 DE 2735537A1 DE 19772735537 DE19772735537 DE 19772735537 DE 2735537 A DE2735537 A DE 2735537A DE 2735537 A1 DE2735537 A1 DE 2735537A1
Authority
DE
Grant status
Application
Patent type
Prior art keywords
indolacetoxyacetylaminosaeurederivate
medicines
manufacture
methods
use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772735537
Other languages
German (de)
Inventor
Karl-Heinz Dipl Chem Dr Boltze
Hans-Dieter Dipl Chem Dr Dell
Haireddin Dr Jacobi
Wolfgang Dipl Chem Dr Opitz
Guenter Dipl In Schoellnhammer
Dieter Dipl Chem Dr Vollbrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0815Tripeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
DE19772735537 1977-08-06 1977-08-06 Indolacetoxyacetylaminosaeurederivate, methods for their manufacture and their use as medicines Withdrawn DE2735537A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19772735537 DE2735537A1 (en) 1977-08-06 1977-08-06 Indolacetoxyacetylaminosaeurederivate, methods for their manufacture and their use as medicines

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19772735537 DE2735537A1 (en) 1977-08-06 1977-08-06 Indolacetoxyacetylaminosaeurederivate, methods for their manufacture and their use as medicines
EP19780100523 EP0000741B1 (en) 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs
DE19782860858 DE2860858D1 (en) 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs
JP9469878A JPS5430160A (en) 1977-08-06 1978-08-04 Novel indoleacetoxyacetylamino acid compound * production thereof and medical use
IT2653778A IT7826537D0 (en) 1977-08-06 1978-08-04 Indolacetossiacetilaminico acid derivatives, process for their production chlorine use as medicaments.

Publications (1)

Publication Number Publication Date
DE2735537A1 true true DE2735537A1 (en) 1979-02-22

Family

ID=6015810

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772735537 Withdrawn DE2735537A1 (en) 1977-08-06 1977-08-06 Indolacetoxyacetylaminosaeurederivate, methods for their manufacture and their use as medicines

Country Status (3)

Country Link
EP (1) EP0000741B1 (en)
JP (1) JPS5430160A (en)
DE (1) DE2735537A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126942A1 (en) * 1983-04-28 1984-12-05 Troponwerke GmbH & Co. KG Preparation process of acemetacin
US4513004A (en) * 1982-02-26 1985-04-23 Troponwerke Gmbh & Co. Kg Indole derivatives, processes for their preparation, and their use as medicaments
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US7718161B2 (en) 2004-06-09 2010-05-18 Ucb Pharma Gmbh Method for treating a motoneuron disorder
US7736624B2 (en) 2006-06-19 2010-06-15 Univ Vanderbilt Methods and compositions for diagnostic and therapeutic targeting of COX-2
US8168656B2 (en) 2004-04-26 2012-05-01 Vanderbilt University Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
US9346803B2 (en) 2011-10-17 2016-05-24 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034005C2 (en) * 1980-09-10 1982-12-09 A. Nattermann & Cie Gmbh, 5000 Koeln, De
DE3206887A1 (en) * 1982-02-26 1983-09-15 Troponwerke Gmbh & Co Kg A process for preparing 1- (4-chlorobenzoyl) -5-methoxy-2-methyl-3-indolacetoxyessigsaeure
JPH0417306Y2 (en) * 1984-12-26 1992-04-17
DE68920022T2 (en) * 1988-07-05 1995-07-20 Zeria Pharm Co Ltd Indole acetic acid derivatives, methods for production and drug containing them as active agents.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2234651C3 (en) * 1972-07-14 1978-11-09 Troponwerke Gmbh & Co Kg, 5000 Koeln
DE2413125C2 (en) * 1974-03-15 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen, De

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513004A (en) * 1982-02-26 1985-04-23 Troponwerke Gmbh & Co. Kg Indole derivatives, processes for their preparation, and their use as medicaments
EP0126942A1 (en) * 1983-04-28 1984-12-05 Troponwerke GmbH & Co. KG Preparation process of acemetacin
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6399647B2 (en) 1999-01-07 2002-06-04 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US8168656B2 (en) 2004-04-26 2012-05-01 Vanderbilt University Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
US7718161B2 (en) 2004-06-09 2010-05-18 Ucb Pharma Gmbh Method for treating a motoneuron disorder
US8143302B2 (en) 2006-06-19 2012-03-27 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of COX-2
US7736624B2 (en) 2006-06-19 2010-06-15 Univ Vanderbilt Methods and compositions for diagnostic and therapeutic targeting of COX-2
US8865130B2 (en) 2006-06-19 2014-10-21 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of COX-2
US9346803B2 (en) 2011-10-17 2016-05-24 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer
US9895351B2 (en) 2011-10-17 2018-02-20 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Also Published As

Publication number Publication date Type
EP0000741A3 (en) 1979-03-07 application
EP0000741A2 (en) 1979-02-21 application
JPS5430160A (en) 1979-03-06 application
EP0000741B1 (en) 1981-07-22 grant

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Legal Events

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8130 Withdrawal