EP0000741A3 - Indolacetoxy acetylamino acid derivatives, process for their preparation and their use as drugs - Google Patents

Indolacetoxy acetylamino acid derivatives, process for their preparation and their use as drugs Download PDF

Info

Publication number
EP0000741A3
EP0000741A3 EP78100523A EP78100523A EP0000741A3 EP 0000741 A3 EP0000741 A3 EP 0000741A3 EP 78100523 A EP78100523 A EP 78100523A EP 78100523 A EP78100523 A EP 78100523A EP 0000741 A3 EP0000741 A3 EP 0000741A3
Authority
EP
European Patent Office
Prior art keywords
indolacetoxy
drugs
preparation
acid derivatives
acetylamino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP78100523A
Other versions
EP0000741A2 (en
EP0000741B1 (en
Inventor
Karl-Heinz Dr. Boltze
Hans-Dieter Dr. Dell
Haireddin Dr. Jacobi
Wolfgang Dr. Opitz
Gunter Schollnhammer
Dieter Dr. Vollbrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke GmbH filed Critical Troponwerke GmbH
Publication of EP0000741A2 publication Critical patent/EP0000741A2/en
Publication of EP0000741A3 publication Critical patent/EP0000741A3/en
Application granted granted Critical
Publication of EP0000741B1 publication Critical patent/EP0000741B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP78100523A 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs Expired EP0000741B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2735537 1977-08-06
DE19772735537 DE2735537A1 (en) 1977-08-06 1977-08-06 INDOLACETOXYACETYLAMINO ACID DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND USE AS A MEDICINAL PRODUCT

Publications (3)

Publication Number Publication Date
EP0000741A2 EP0000741A2 (en) 1979-02-21
EP0000741A3 true EP0000741A3 (en) 1979-03-07
EP0000741B1 EP0000741B1 (en) 1981-07-22

Family

ID=6015810

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78100523A Expired EP0000741B1 (en) 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs

Country Status (4)

Country Link
EP (1) EP0000741B1 (en)
JP (1) JPS5430160A (en)
DE (2) DE2735537A1 (en)
IT (1) IT7826537A0 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034005C2 (en) * 1980-09-10 1982-12-09 A. Nattermann & Cie GmbH, 5000 Köln Indole acetic acid derivatives, process for their preparation and pharmaceutical preparations containing them
DE3206885A1 (en) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln INDOLDER DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE3206887A1 (en) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln METHOD FOR THE PRODUCTION OF 1- (4-CHLOROBENZOYL) -5-METHOXY-2-METHYL-3-INDOLACETOXYACETIC ACID
JPS59204172A (en) * 1983-04-28 1984-11-19 Kowa Co Preparation of acemetacin
JPH0417306Y2 (en) * 1984-12-26 1992-04-17
ATE115564T1 (en) * 1988-07-05 1994-12-15 Zeria Pharm Co Ltd INDOLEACETIC ACID DERIVATIVES, PROCESSES FOR MANUFACTURE AND PHARMACEUTICALS CONTAINING THEM AS ACTIVE INGREDIENTS.
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
CN101031289A (en) 2004-04-26 2007-09-05 范德比尔特大学 Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
CN101528222A (en) 2006-06-19 2009-09-09 范德比尔特大学 Methods and compositions for diagnostic and therapeutic targeting of COX-2
WO2013059245A1 (en) 2011-10-17 2013-04-25 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2192828A1 (en) * 1972-07-14 1974-02-15 Troponwerke Dinklage & Co
DE2413125A1 (en) * 1974-03-15 1975-10-09 Schering Ag INDOLYLACETYLAMINO ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2192828A1 (en) * 1972-07-14 1974-02-15 Troponwerke Dinklage & Co
DE2413125A1 (en) * 1974-03-15 1975-10-09 Schering Ag INDOLYLACETYLAMINO ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
DE2735537A1 (en) 1979-02-22
EP0000741A2 (en) 1979-02-21
IT7826537A0 (en) 1978-08-04
DE2860858D1 (en) 1981-10-29
EP0000741B1 (en) 1981-07-22
JPS5430160A (en) 1979-03-06

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