DE2860858D1 - Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs - Google Patents

Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs

Info

Publication number
DE2860858D1
DE2860858D1 DE7878100523T DE2860858T DE2860858D1 DE 2860858 D1 DE2860858 D1 DE 2860858D1 DE 7878100523 T DE7878100523 T DE 7878100523T DE 2860858 T DE2860858 T DE 2860858T DE 2860858 D1 DE2860858 D1 DE 2860858D1
Authority
DE
Germany
Prior art keywords
indolacetoxyacetylaminoacid
drugs
derivatives
preparation
indolacetoxyacetylaminoacid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878100523T
Other languages
German (de)
Inventor
Karl-Heinz Dr Boltze
Hans-Dieter Dr Dell
Haireddin Dr Jacobi
Wolfgang Dr Opitz
Gunter Schollnhammer
Dieter Dr Vollbrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke GmbH filed Critical Troponwerke GmbH
Priority to DE7878100523T priority Critical patent/DE2860858D1/en
Application granted granted Critical
Publication of DE2860858D1 publication Critical patent/DE2860858D1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE7878100523T 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs Expired DE2860858D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE7878100523T DE2860858D1 (en) 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772735537 DE2735537A1 (en) 1977-08-06 1977-08-06 INDOLACETOXYACETYLAMINO ACID DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND USE AS A MEDICINAL PRODUCT
DE7878100523T DE2860858D1 (en) 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs

Publications (1)

Publication Number Publication Date
DE2860858D1 true DE2860858D1 (en) 1981-10-29

Family

ID=6015810

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19772735537 Withdrawn DE2735537A1 (en) 1977-08-06 1977-08-06 INDOLACETOXYACETYLAMINO ACID DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND USE AS A MEDICINAL PRODUCT
DE7878100523T Expired DE2860858D1 (en) 1977-08-06 1978-07-27 Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19772735537 Withdrawn DE2735537A1 (en) 1977-08-06 1977-08-06 INDOLACETOXYACETYLAMINO ACID DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND USE AS A MEDICINAL PRODUCT

Country Status (4)

Country Link
EP (1) EP0000741B1 (en)
JP (1) JPS5430160A (en)
DE (2) DE2735537A1 (en)
IT (1) IT7826537A0 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034005C2 (en) * 1980-09-10 1982-12-09 A. Nattermann & Cie GmbH, 5000 Köln Indole acetic acid derivatives, process for their preparation and pharmaceutical preparations containing them
DE3206885A1 (en) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln INDOLDER DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE3206887A1 (en) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln METHOD FOR THE PRODUCTION OF 1- (4-CHLOROBENZOYL) -5-METHOXY-2-METHYL-3-INDOLACETOXYACETIC ACID
JPS59204172A (en) * 1983-04-28 1984-11-19 Kowa Co Preparation of acemetacin
JPH0417306Y2 (en) * 1984-12-26 1992-04-17
ATE115564T1 (en) * 1988-07-05 1994-12-15 Zeria Pharm Co Ltd INDOLEACETIC ACID DERIVATIVES, PROCESSES FOR MANUFACTURE AND PHARMACEUTICALS CONTAINING THEM AS ACTIVE INGREDIENTS.
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
CN101031289A (en) 2004-04-26 2007-09-05 范德比尔特大学 Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
CA2657691A1 (en) 2006-06-19 2007-12-27 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of cox-2
EP3078374B1 (en) 2011-10-17 2019-06-19 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2234651C3 (en) * 1972-07-14 1978-11-09 Troponwerke Gmbh & Co Kg, 5000 Koeln Square brackets on l- (p-chlorobenzoyl) -5-methoxy-2-methyl-3-indole] -acetoxj acetic acid, its salts with bases, processes for their production and pharmacological preparations
DE2413125C2 (en) * 1974-03-15 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Indolylacetylamino acid derivatives, processes for their production and medicinal preparations containing these compounds

Also Published As

Publication number Publication date
EP0000741B1 (en) 1981-07-22
IT7826537A0 (en) 1978-08-04
JPS5430160A (en) 1979-03-06
EP0000741A3 (en) 1979-03-07
EP0000741A2 (en) 1979-02-21
DE2735537A1 (en) 1979-02-22

Similar Documents

Publication Publication Date Title
DE2861688D1 (en) Quinazoline derivatives, process for their preparation, pharmaceutical preparations and their preparation
DE3065026D1 (en) Phenylsulphonamide derivatives, a process for their preparation and their use as medicines
ZA785517B (en) New pyrrole derivatives,process for their preparation and therapeutic applications thereof
DE2860342D1 (en) Glycylmethyl-phosphinic acid derivatives, their preparation and their use
HK23782A (en) Amino-sugar derivatives,process for their preparation and their use as medicaments
GB1523081A (en) 3,4-dihydro - quinazoline derivatives and process for their preparation
DE2860858D1 (en) Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs
DE2860077D1 (en) Cycloaminals, process for their preparation and their application
IL59665A0 (en) Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
GB2008106A (en) Quinazoline derivatives process for preparing the same and anthypertensive drugs containing the same
DE2860981D1 (en) 4-hydroxy-2-benzimidazolinone derivatives, process for their preparation and their use in medicaments
IL55862A0 (en) Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositionss containing them
DE2860410D1 (en) 2-piperazinotetraline derivatives, their preparation and their use as medicines
JPS5287192A (en) 77aminothiazolylacetoamid cephalospolanate derivatives process for preparing same and pharmaceutical composition
GB1553661A (en) P-amino-methyl-benzene-sulphonamide derivatives process for their preparation and application thereof
DE2860111D1 (en) New bispidine derivatives, process for their preparation and medicinal preparations containing them
CY1263A (en) Glucofuranos-6-yl-nitroso urea derivatives,processes for their preparation and their use in pharmaceutical compositions
DE2861179D1 (en) Indole derivatives, their preparation and use in pharmaceutical compositions
ZA786749B (en) Substituted pyrrolidines,process for their preparation,their use and medicaments containing them
GB1538705A (en) 1,4-dihydropyridine-sugar derivatives process for their preparation and their use as medicaments
DE2860659D1 (en) 1,4-dihydropyridazines, process for their preparation and their use in pharmaceuticals
IL59664A0 (en) Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
EP0000791A3 (en) Medicament-substituted hapten conjugates, process for their preparation, their use as pharmaceuticals and hapten used in their preparation
IL55138A0 (en) Bis-polyol derivatives and process for their preparation
ZA776716B (en) Substituted o-phenylenediaminde derivatives processes for their preparation and their use as medicaments