PT74618A - Process for preparing dipeptides containing thialysine and ho- mologs as antihypertensives - Google Patents

Process for preparing dipeptides containing thialysine and ho- mologs as antihypertensives

Info

Publication number
PT74618A
PT74618A PT74618A PT7461882A PT74618A PT 74618 A PT74618 A PT 74618A PT 74618 A PT74618 A PT 74618A PT 7461882 A PT7461882 A PT 7461882A PT 74618 A PT74618 A PT 74618A
Authority
PT
Portugal
Prior art keywords
mologs
thialysine
antihypertensives
dipeptides containing
preparing
Prior art date
Application number
PT74618A
Other languages
English (en)
Other versions
PT74618B (en
Inventor
Arthur A Patchett
Mu Ts Wu
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT74618A publication Critical patent/PT74618A/pt
Publication of PT74618B publication Critical patent/PT74618B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT74618A 1981-03-23 1982-03-22 Process for preparing dipeptides containing thialysine and ho- mologs as antihypertensives PT74618B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24653281A 1981-03-23 1981-03-23
US06/341,741 US4512979A (en) 1981-03-23 1982-01-26 Dipeptides containing thialysine and related amino acids as antihypertensives

Publications (2)

Publication Number Publication Date
PT74618A true PT74618A (en) 1982-04-01
PT74618B PT74618B (en) 1984-11-26

Family

ID=26938058

Family Applications (1)

Application Number Title Priority Date Filing Date
PT74618A PT74618B (en) 1981-03-23 1982-03-22 Process for preparing dipeptides containing thialysine and ho- mologs as antihypertensives

Country Status (8)

Country Link
US (1) US4512979A (pt)
EP (1) EP0061186B1 (pt)
DE (1) DE3271236D1 (pt)
DK (1) DK127482A (pt)
ES (1) ES8305700A1 (pt)
GR (1) GR76467B (pt)
IE (1) IE52294B1 (pt)
PT (1) PT74618B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046953B1 (de) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4766110A (en) * 1981-08-21 1988-08-23 Ryan James W Novel complex amido and imido derivatives of carboxyalkyl peptides
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
DE3378266D1 (en) * 1982-01-11 1988-11-24 Merck & Co Inc Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4584299A (en) * 1984-05-21 1986-04-22 Warner-Lambert Company Method of treating heart failure and medicaments therefor
JPH0662671B2 (ja) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 プロリン誘導体
US4847384A (en) * 1987-03-12 1989-07-11 Sandoz Pharm. Corp. Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor
WO1991000356A1 (en) * 1989-06-30 1991-01-10 Massachusetts Institute Of Technology Inhibition of the n-end rule pathway in living cells
US6620848B2 (en) * 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
MY117948A (en) * 1997-01-13 2004-08-30 Glaxo Group Ltd Nitride oxide synthase inhibitors.
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
SG10201702387YA (en) 2012-09-24 2017-04-27 Medimmune Ltd Cell lines
CN105247049B (zh) 2013-03-15 2019-09-13 米迪缪尼有限公司 新型核酸分子
WO2015019192A2 (en) * 2013-08-05 2015-02-12 Medimmune Limited Amino acid derivatives
CN114920676B (zh) * 2022-06-07 2024-04-05 四川国康药业有限公司 一种治疗呼吸系统疾病的化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
GR73585B (pt) * 1978-09-11 1984-03-26 Univ Miami
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides

Also Published As

Publication number Publication date
ES510663A0 (es) 1983-04-16
ES8305700A1 (es) 1983-04-16
IE52294B1 (en) 1987-09-02
DK127482A (da) 1982-09-24
GR76467B (pt) 1984-08-10
US4512979A (en) 1985-04-23
IE820637L (en) 1982-09-23
PT74618B (en) 1984-11-26
EP0061186B1 (en) 1986-05-21
EP0061186A1 (en) 1982-09-29
DE3271236D1 (en) 1986-06-26

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