PT73864A - Prepn. of 17 alpha-hydroxy-pregn-3-en-3,20-di:one 17-ester(s) - by esterification with two strong acids present and acyl anhydride (PT 8.6.82) - Google Patents
Prepn. of 17 alpha-hydroxy-pregn-3-en-3,20-di:one 17-ester(s) - by esterification with two strong acids present and acyl anhydride (PT 8.6.82)Info
- Publication number
- PT73864A PT73864A PT7386481A PT7386481A PT73864A PT 73864 A PT73864 A PT 73864A PT 7386481 A PT7386481 A PT 7386481A PT 7386481 A PT7386481 A PT 7386481A PT 73864 A PT73864 A PT 73864A
- Authority
- PT
- Portugal
- Prior art keywords
- alpha
- hydroxy
- prepn
- ester
- pregn
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Prepn. of 17 alpha-hydroxy pregn.- 3-en-3,20-dione 17-ester of formula (I) comprises esterifying corresp. 11-R8-17 alpha-hydroxy cpd. (II). X is H, F or Cl; R1 is H, F, Cl or Me; R2 is H + Halogen, H + OH or O; R3 is H, alpha-Me or beta-me; R4 is 1-16C alkoxoyl, 3-16C cycloalkanoyl, 7-8C aralkanoyl or Ph CO; either Y is H and Y1 is OH, OR4, halo or H, or Y and Y1 are both halo; and R8 is oxo, H + halo or H + trihaloacetoxy. Specifically claimed cpds. include 9 alpha- fluoro- 11- beta, 17 alpha- dihydloxy- 16-beta methyl pregna-1,4-diene- 3, 20 dione 17-heptanoate. (I) are obtd. by a new and efficient route they include known antiinflammatory agents. For topical application, ointments suitably contain 0.01-0.25 wt.% (I). Used e.g. for treating eczema.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT7386481A PT73864B (en) | 1981-10-22 | 1981-10-22 | NEW PROCESS FOR THE PREPARATION OF CORTISTEROID STERES |
IL66432A IL66432A0 (en) | 1981-08-04 | 1982-08-01 | Process for the preparation of steroidal esters |
KR8203473A KR850000769B1 (en) | 1981-08-04 | 1982-08-03 | Process for the preparation of steroidal esters |
ES514708A ES8405420A1 (en) | 1981-08-04 | 1982-08-03 | Steroidal esters and process for the preparation of steroidal esters. |
AT82304116T ATE16601T1 (en) | 1981-08-04 | 1982-08-04 | STEROIDESTERS AND METHODS OF PRODUCTION OF STEROIDESTERS. |
DE8282304116T DE3267586D1 (en) | 1981-08-04 | 1982-08-04 | Steroidal esters and process for the preparation of steroidal esters |
EP82304116A EP0072200B1 (en) | 1981-08-04 | 1982-08-04 | Steroidal esters and process for the preparation of steroidal esters |
US06/641,267 US4655971A (en) | 1981-08-04 | 1984-08-16 | Novel process for the preparation of steroidal esters |
HK431/90A HK43190A (en) | 1981-08-04 | 1990-06-07 | Steroidal esters and process for the preparation of steroidal esters |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT7386481A PT73864B (en) | 1981-10-22 | 1981-10-22 | NEW PROCESS FOR THE PREPARATION OF CORTISTEROID STERES |
Publications (2)
Publication Number | Publication Date |
---|---|
PT73864A true PT73864A (en) | 1981-11-01 |
PT73864B PT73864B (en) | 1983-01-25 |
Family
ID=20083004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT7386481A PT73864B (en) | 1981-08-04 | 1981-10-22 | NEW PROCESS FOR THE PREPARATION OF CORTISTEROID STERES |
Country Status (1)
Country | Link |
---|---|
PT (1) | PT73864B (en) |
-
1981
- 1981-10-22 PT PT7386481A patent/PT73864B/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT73864B (en) | 1983-01-25 |
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