PT73864A - Prepn. of 17 alpha-hydroxy-pregn-3-en-3,20-di:one 17-ester(s) - by esterification with two strong acids present and acyl anhydride (PT 8.6.82) - Google Patents

Prepn. of 17 alpha-hydroxy-pregn-3-en-3,20-di:one 17-ester(s) - by esterification with two strong acids present and acyl anhydride (PT 8.6.82)

Info

Publication number
PT73864A
PT73864A PT7386481A PT7386481A PT73864A PT 73864 A PT73864 A PT 73864A PT 7386481 A PT7386481 A PT 7386481A PT 7386481 A PT7386481 A PT 7386481A PT 73864 A PT73864 A PT 73864A
Authority
PT
Portugal
Prior art keywords
alpha
hydroxy
prepn
ester
pregn
Prior art date
Application number
PT7386481A
Other languages
French (fr)
Portuguese (pt)
Other versions
PT73864B (en
Inventor
Philip Ronald Page
William Heggie
Original Assignee
Hovione Soc Ind E Com De Produ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Soc Ind E Com De Produ filed Critical Hovione Soc Ind E Com De Produ
Priority to PT7386481A priority Critical patent/PT73864B/en
Publication of PT73864A publication Critical patent/PT73864A/en
Priority to IL66432A priority patent/IL66432A0/en
Priority to KR8203473A priority patent/KR850000769B1/en
Priority to ES514708A priority patent/ES8405420A1/en
Priority to AT82304116T priority patent/ATE16601T1/en
Priority to DE8282304116T priority patent/DE3267586D1/en
Priority to EP82304116A priority patent/EP0072200B1/en
Publication of PT73864B publication Critical patent/PT73864B/en
Priority to US06/641,267 priority patent/US4655971A/en
Priority to HK431/90A priority patent/HK43190A/en

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  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Prepn. of 17 alpha-hydroxy pregn.- 3-en-3,20-dione 17-ester of formula (I) comprises esterifying corresp. 11-R8-17 alpha-hydroxy cpd. (II). X is H, F or Cl; R1 is H, F, Cl or Me; R2 is H + Halogen, H + OH or O; R3 is H, alpha-Me or beta-me; R4 is 1-16C alkoxoyl, 3-16C cycloalkanoyl, 7-8C aralkanoyl or Ph CO; either Y is H and Y1 is OH, OR4, halo or H, or Y and Y1 are both halo; and R8 is oxo, H + halo or H + trihaloacetoxy. Specifically claimed cpds. include 9 alpha- fluoro- 11- beta, 17 alpha- dihydloxy- 16-beta methyl pregna-1,4-diene- 3, 20 dione 17-heptanoate. (I) are obtd. by a new and efficient route they include known antiinflammatory agents. For topical application, ointments suitably contain 0.01-0.25 wt.% (I). Used e.g. for treating eczema.
PT7386481A 1981-08-04 1981-10-22 NEW PROCESS FOR THE PREPARATION OF CORTISTEROID STERES PT73864B (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
PT7386481A PT73864B (en) 1981-10-22 1981-10-22 NEW PROCESS FOR THE PREPARATION OF CORTISTEROID STERES
IL66432A IL66432A0 (en) 1981-08-04 1982-08-01 Process for the preparation of steroidal esters
KR8203473A KR850000769B1 (en) 1981-08-04 1982-08-03 Process for the preparation of steroidal esters
ES514708A ES8405420A1 (en) 1981-08-04 1982-08-03 Steroidal esters and process for the preparation of steroidal esters.
AT82304116T ATE16601T1 (en) 1981-08-04 1982-08-04 STEROIDESTERS AND METHODS OF PRODUCTION OF STEROIDESTERS.
DE8282304116T DE3267586D1 (en) 1981-08-04 1982-08-04 Steroidal esters and process for the preparation of steroidal esters
EP82304116A EP0072200B1 (en) 1981-08-04 1982-08-04 Steroidal esters and process for the preparation of steroidal esters
US06/641,267 US4655971A (en) 1981-08-04 1984-08-16 Novel process for the preparation of steroidal esters
HK431/90A HK43190A (en) 1981-08-04 1990-06-07 Steroidal esters and process for the preparation of steroidal esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT7386481A PT73864B (en) 1981-10-22 1981-10-22 NEW PROCESS FOR THE PREPARATION OF CORTISTEROID STERES

Publications (2)

Publication Number Publication Date
PT73864A true PT73864A (en) 1981-11-01
PT73864B PT73864B (en) 1983-01-25

Family

ID=20083004

Family Applications (1)

Application Number Title Priority Date Filing Date
PT7386481A PT73864B (en) 1981-08-04 1981-10-22 NEW PROCESS FOR THE PREPARATION OF CORTISTEROID STERES

Country Status (1)

Country Link
PT (1) PT73864B (en)

Also Published As

Publication number Publication date
PT73864B (en) 1983-01-25

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