PT73050B - Procede de preparation de nouveaux derives de l'acide 4-hydroxy-3-quinoleine carboxylique substitues en 2 et de compositions pharmaceutiques qui les contiennent - Google Patents
Procede de preparation de nouveaux derives de l'acide 4-hydroxy-3-quinoleine carboxylique substitues en 2 et de compositions pharmaceutiques qui les contiennentInfo
- Publication number
- PT73050B PT73050B PT73050A PT7305081A PT73050B PT 73050 B PT73050 B PT 73050B PT 73050 A PT73050 A PT 73050A PT 7305081 A PT7305081 A PT 7305081A PT 73050 B PT73050 B PT 73050B
- Authority
- PT
- Portugal
- Prior art keywords
- carbon atoms
- group
- alkyl
- hydrogen
- halogen
- Prior art date
Links
- -1 2-SUBSTITUTED 4-HYDROXY-3-QUINOLINE CARBOXYLIC ACID Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Measurement Of Radiation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Control Of Steam Boilers And Waste-Gas Boilers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8011100A FR2482596A1 (fr) | 1980-05-19 | 1980-05-19 | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT73050A PT73050A (fr) | 1981-06-01 |
| PT73050B true PT73050B (fr) | 1983-02-08 |
Family
ID=9242091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT73050A PT73050B (fr) | 1980-05-19 | 1981-05-18 | Procede de preparation de nouveaux derives de l'acide 4-hydroxy-3-quinoleine carboxylique substitues en 2 et de compositions pharmaceutiques qui les contiennent |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4397856A (en, 2012) |
| EP (2) | EP0143123B1 (en, 2012) |
| JP (1) | JPS5731665A (en, 2012) |
| AT (2) | ATE8783T1 (en, 2012) |
| AU (1) | AU543580B2 (en, 2012) |
| CA (1) | CA1184558A (en, 2012) |
| DE (2) | DE3165209D1 (en, 2012) |
| DK (1) | DK152212C (en, 2012) |
| ES (1) | ES502264A0 (en, 2012) |
| FI (1) | FI77030C (en, 2012) |
| FR (1) | FR2482596A1 (en, 2012) |
| HU (1) | HU184853B (en, 2012) |
| IE (1) | IE56506B1 (en, 2012) |
| OA (1) | OA06814A (en, 2012) |
| PH (2) | PH17403A (en, 2012) |
| PT (1) | PT73050B (en, 2012) |
| ZA (1) | ZA813293B (en, 2012) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| HU190796B (en) * | 1981-06-12 | 1986-11-28 | Roussel Uclaf,Fr | Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives |
| FR2530633A1 (fr) * | 1982-06-03 | 1984-01-27 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant |
| FR2532314B1 (fr) * | 1982-08-25 | 1985-07-19 | Roussel Uclaf | Nouveau procede de preparation de derives de l'acide 3-quinoleine carboxylique, nouveaux derives halogenes de l'acide 3-quinoleine carboxylique, leur application comme medicaments, les compositions pharmaceutiques les renfermant et les intermediaires nouveaux obtenus |
| FR2553769B1 (fr) * | 1983-10-20 | 1986-03-14 | Roussel Uclaf | Nouveau procede de preparation de derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 |
| US4731480A (en) * | 1985-07-29 | 1988-03-15 | Ortho Pharmaceutical Corporation | Process for preparing 2-acyl-3,4-dialkoxyanilines |
| US4844732A (en) * | 1985-10-24 | 1989-07-04 | Daicel Chemical Industries Ltd. | Pyridine-3-carboxamide derivatives |
| IE68593B1 (en) * | 1989-12-06 | 1996-06-26 | Sanofi Sa | Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them |
| DE4410539A1 (de) * | 1994-03-26 | 1995-09-28 | Sandoz Ag | Verwendung von 4 H-3,1-Benzoxazin-4-on-Verbindungen zur Verbesserung der Lichtechtheit von Textilmaterialien |
| ATE303993T1 (de) * | 1997-12-22 | 2005-09-15 | Pharmacia & Upjohn Co Llc | 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe |
| US20080312435A1 (en) * | 2004-11-15 | 2008-12-18 | Taisho Pharmaceutical Co., Ltd. | Imine Compound |
| EP2609084A1 (en) | 2010-08-27 | 2013-07-03 | Grünenthal GmbH | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
| RU2595894C2 (ru) | 2010-08-27 | 2016-08-27 | Грюненталь Гмбх | Замещенные 2-окси-хинолин-3-карбоксамиды в качестве модуляторов kcnq2/3 |
| CN103189357B (zh) | 2010-08-27 | 2015-11-25 | 格吕伦塔尔有限公司 | 作为kcnq2/3调节剂的取代的2-氧代-和2-硫代-二氢喹啉-3-甲酰胺 |
| AU2011295407B2 (en) | 2010-08-27 | 2016-01-21 | Grunenthal Gmbh | Substituted quinoline-3-carboxamides as KCNQ2/3 modulators |
| EP2611780A1 (en) | 2010-09-01 | 2013-07-10 | Grünenthal GmbH | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB874980A (en) * | 1958-12-17 | 1961-08-16 | Imp Cmemical Ind Ltd | Quinoline derivatives |
| US3357977A (en) * | 1964-01-06 | 1967-12-12 | Minnesota Mining & Mfg | Novel anthranyl intermediates |
| HU173974B (hu) * | 1971-08-30 | 1979-10-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija proizvodnykh 3,1-benzoksazin-4-ona |
| GB1410178A (en) | 1972-03-13 | 1975-10-15 | Pfizer | Substituted quinazolinones as herbicides |
| CA1034124A (en) * | 1973-05-11 | 1978-07-04 | Ciba-Geigy Ag | Process for the manufacture of new quinolines |
| FR2281761A1 (fr) * | 1974-08-13 | 1976-03-12 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| US3989698A (en) * | 1975-02-20 | 1976-11-02 | The Sherwin-Williams Company | Process for preparing benzoxazines |
| FR2340735A1 (fr) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2377400A2 (fr) * | 1977-01-18 | 1978-08-11 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2443467A1 (fr) * | 1978-12-08 | 1980-07-04 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| US4229831A (en) * | 1978-12-22 | 1980-10-21 | Burroughs Corporation | Drift compensated fiber optic-receiver |
-
1980
- 1980-05-19 FR FR8011100A patent/FR2482596A1/fr active Granted
-
1981
- 1981-05-12 US US06/262,952 patent/US4397856A/en not_active Expired - Lifetime
- 1981-05-13 PH PH25627A patent/PH17403A/en unknown
- 1981-05-15 CA CA000377751A patent/CA1184558A/fr not_active Expired
- 1981-05-18 PT PT73050A patent/PT73050B/pt not_active IP Right Cessation
- 1981-05-18 ES ES502264A patent/ES502264A0/es active Granted
- 1981-05-18 DK DK217281A patent/DK152212C/da not_active IP Right Cessation
- 1981-05-18 HU HU811403A patent/HU184853B/hu not_active IP Right Cessation
- 1981-05-18 AU AU70689/81A patent/AU543580B2/en not_active Ceased
- 1981-05-18 ZA ZA00813293A patent/ZA813293B/xx unknown
- 1981-05-18 IE IE1112/81A patent/IE56506B1/en not_active IP Right Cessation
- 1981-05-18 FI FI811529A patent/FI77030C/fi not_active IP Right Cessation
- 1981-05-19 OA OA57407A patent/OA06814A/xx unknown
- 1981-05-19 EP EP83201252A patent/EP0143123B1/fr not_active Expired - Lifetime
- 1981-05-19 DE DE8181400783T patent/DE3165209D1/de not_active Expired
- 1981-05-19 DE DE8383201252T patent/DE3177205D1/de not_active Expired - Fee Related
- 1981-05-19 JP JP7434181A patent/JPS5731665A/ja active Granted
- 1981-05-19 EP EP81400783A patent/EP0040573B1/fr not_active Expired
- 1981-05-19 AT AT81400783T patent/ATE8783T1/de not_active IP Right Cessation
- 1981-05-19 AT AT83201252T patent/ATE54913T1/de not_active IP Right Cessation
-
1983
- 1983-05-17 US US06/495,475 patent/US4518775A/en not_active Expired - Lifetime
- 1983-09-02 PH PH29488A patent/PH21164A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU184853B (en) | 1984-10-29 |
| FR2482596A1 (fr) | 1981-11-20 |
| DK152212C (da) | 1988-08-08 |
| FR2482596B1 (en, 2012) | 1983-04-29 |
| EP0040573A2 (fr) | 1981-11-25 |
| EP0040573A3 (en) | 1982-01-13 |
| US4518775A (en) | 1985-05-21 |
| OA06814A (fr) | 1982-12-31 |
| EP0143123A3 (en) | 1986-09-03 |
| DK152212B (da) | 1988-02-08 |
| AU7068981A (en) | 1981-11-26 |
| ES8203889A1 (es) | 1982-04-01 |
| JPS6340430B2 (en, 2012) | 1988-08-11 |
| CA1184558A (fr) | 1985-03-26 |
| US4397856A (en) | 1983-08-09 |
| AU543580B2 (en) | 1985-04-26 |
| DE3165209D1 (en) | 1984-09-06 |
| ZA813293B (en) | 1982-05-26 |
| DE3177205D1 (de) | 1990-08-30 |
| EP0040573B1 (fr) | 1984-08-01 |
| FI77030C (fi) | 1989-01-10 |
| IE56506B1 (en) | 1991-08-28 |
| ATE54913T1 (de) | 1990-08-15 |
| ES502264A0 (es) | 1982-04-01 |
| EP0143123B1 (fr) | 1990-07-25 |
| ATE8783T1 (de) | 1984-08-15 |
| IE811112L (en) | 1981-11-19 |
| PH21164A (en) | 1987-08-05 |
| FI811529L (fi) | 1981-11-20 |
| JPS5731665A (en) | 1982-02-20 |
| PH17403A (en) | 1984-08-08 |
| PT73050A (fr) | 1981-06-01 |
| EP0143123A2 (fr) | 1985-06-05 |
| FI77030B (fi) | 1988-09-30 |
| DK217281A (da) | 1981-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000831 |