PT71644B - Verfahren zur herstellung von 4-phenoxypiperidinen - Google Patents
Verfahren zur herstellung von 4-phenoxypiperidinenInfo
- Publication number
- PT71644B PT71644B PT71644A PT7164480A PT71644B PT 71644 B PT71644 B PT 71644B PT 71644 A PT71644 A PT 71644A PT 7164480 A PT7164480 A PT 7164480A PT 71644 B PT71644 B PT 71644B
- Authority
- PT
- Portugal
- Prior art keywords
- group
- carbon atoms
- denotes
- phenoxypiperidines
- hydrogen atom
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- KBYPITRKIJKGMD-UHFFFAOYSA-N 4-phenoxypiperidine Chemical class C1CNCCC1OC1=CC=CC=C1 KBYPITRKIJKGMD-UHFFFAOYSA-N 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001867 anti-ptotic effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH712779 | 1979-08-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT71644A PT71644A (de) | 1980-09-01 |
| PT71644B true PT71644B (de) | 1982-01-21 |
Family
ID=4320395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT71644A PT71644B (de) | 1979-08-03 | 1980-08-01 | Verfahren zur herstellung von 4-phenoxypiperidinen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4333942A (en, 2012) |
| EP (1) | EP0023706B1 (en, 2012) |
| JP (1) | JPS5626876A (en, 2012) |
| AT (1) | ATE2670T1 (en, 2012) |
| AU (1) | AU534786B2 (en, 2012) |
| CA (1) | CA1147733A (en, 2012) |
| DE (1) | DE3062207D1 (en, 2012) |
| DK (1) | DK334480A (en, 2012) |
| ES (1) | ES8104991A1 (en, 2012) |
| GR (1) | GR69902B (en, 2012) |
| IE (1) | IE50079B1 (en, 2012) |
| IL (1) | IL60715A (en, 2012) |
| NZ (1) | NZ194528A (en, 2012) |
| PT (1) | PT71644B (en, 2012) |
| ZA (1) | ZA804696B (en, 2012) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910351A (en) * | 1987-03-16 | 1990-03-20 | E. I. Du Pont De Nemours And Company | Process for preparing (polyfluoroalkyl)polyfluoroarenes |
| US4853384A (en) * | 1988-03-14 | 1989-08-01 | Hoechst-Roussel Pharmaceuticals Inc. | 1-carbonyl derivatives of 4-aryl-4-aryloxypiperidines |
| US4954511A (en) * | 1988-03-14 | 1990-09-04 | Hoechst-Roussell Pharmaceuticals Inc. | 4-pentafluorophenoxypiperidines |
| US4914204A (en) * | 1988-03-14 | 1990-04-03 | Hoechst-Roussel Pharmaceuticals Incorporated | 4-Pentafluorophenoxypiperidines |
| US5109002A (en) * | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| SE9904724D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| US7851629B2 (en) * | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| SE0401465D0 (sv) * | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| DE602005017784D1 (de) * | 2004-06-08 | 2009-12-31 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission |
| CN101056854B (zh) * | 2004-10-13 | 2013-06-05 | Nsab神经研究瑞典公司分公司 | 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 |
| EP1807394A1 (en) * | 2004-10-13 | 2007-07-18 | Neurosearch Sweden AB | Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines |
| ITTO20050234A1 (it) * | 2005-04-08 | 2006-10-09 | Univ Pisa | Derivati 4-arilpiperidinici e loro uso per la preparazione di un medicamento per il trattamento di disordini del snc |
| SE529246C2 (sv) * | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| EP2787997A4 (en) | 2011-12-08 | 2015-05-27 | Ivax Int Gmbh | HYDROBROMIDE SALT OF PRIDOPIDINE |
| HK1206297A1 (en) | 2012-04-04 | 2016-01-08 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for combination therapy |
| WO2015070091A1 (en) | 2013-11-07 | 2015-05-14 | The University Of Kansas | Biphenylamide derivative hsp90 inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB895309A (en) * | 1959-11-18 | 1962-05-02 | Res Lab Dr C Janssen Nv | Pyrrolidine and piperidine derivatives |
| FR1799M (fr) * | 1961-03-22 | 1963-04-29 | Res Lab Nv | Dérivés des 4-alcoxy-4-phénylpipéridines a substituants alcoyles supérieurs sur l'azote. |
| DE1289529B (de) | 1961-03-22 | 1969-02-20 | Janssen Pharmaceutica Nv | N-phenylalkylierte 4-Alkoxy-4-phenylpiperidine, ihre Saeureadditionssalze und Verfahren zu ihrer Herstellung |
| US3260723A (en) * | 1963-08-27 | 1966-07-12 | Parke Davis & Co | 4-phenoxy piperidines; alpha4-phenoxy piperideines |
| US3551433A (en) * | 1967-06-21 | 1970-12-29 | Us Army | Preparation of 4-phenyl-4-acyloxypiperidine |
| US3506671A (en) * | 1967-11-01 | 1970-04-14 | Smithkline Corp | 1-naphthylalkyl-4-phenylpiperidine derivatives |
| SE7708555L (sv) * | 1976-08-05 | 1978-02-06 | Delmar Chem | 4-arylpiperidinderivat och forfarande for framstellning derav |
| US4116963A (en) | 1977-05-23 | 1978-09-26 | G.D. Searle & Co. | 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy piperidines and related compounds |
| US4216218A (en) * | 1979-02-23 | 1980-08-05 | American Hoechst Corporation | Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines |
-
1980
- 1980-07-11 US US06/167,628 patent/US4333942A/en not_active Expired - Lifetime
- 1980-07-31 IL IL60715A patent/IL60715A/xx unknown
- 1980-08-01 EP EP80104543A patent/EP0023706B1/de not_active Expired
- 1980-08-01 CA CA000357516A patent/CA1147733A/en not_active Expired
- 1980-08-01 ES ES493922A patent/ES8104991A1/es not_active Expired
- 1980-08-01 IE IE1615/80A patent/IE50079B1/en unknown
- 1980-08-01 NZ NZ194528A patent/NZ194528A/xx unknown
- 1980-08-01 DK DK334480A patent/DK334480A/da not_active Application Discontinuation
- 1980-08-01 PT PT71644A patent/PT71644B/pt unknown
- 1980-08-01 ZA ZA00804696A patent/ZA804696B/xx unknown
- 1980-08-01 GR GR62590A patent/GR69902B/el unknown
- 1980-08-01 AU AU61015/80A patent/AU534786B2/en not_active Ceased
- 1980-08-01 JP JP10523180A patent/JPS5626876A/ja active Pending
- 1980-08-01 AT AT80104543T patent/ATE2670T1/de not_active IP Right Cessation
- 1980-08-01 DE DE8080104543T patent/DE3062207D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3062207D1 (en) | 1983-04-07 |
| EP0023706B1 (de) | 1983-03-02 |
| IL60715A (en) | 1983-12-30 |
| ES493922A0 (es) | 1981-06-01 |
| IE801615L (en) | 1981-02-03 |
| NZ194528A (en) | 1982-05-25 |
| AU534786B2 (en) | 1984-02-16 |
| GR69902B (en, 2012) | 1982-07-20 |
| EP0023706A1 (de) | 1981-02-11 |
| ATE2670T1 (de) | 1986-03-15 |
| IL60715A0 (en) | 1980-09-16 |
| PT71644A (de) | 1980-09-01 |
| DK334480A (da) | 1981-02-04 |
| IE50079B1 (en) | 1986-02-05 |
| AU6101580A (en) | 1981-02-05 |
| JPS5626876A (en) | 1981-03-16 |
| ES8104991A1 (es) | 1981-06-01 |
| CA1147733A (en) | 1983-06-07 |
| ZA804696B (en) | 1981-08-26 |
| US4333942A (en) | 1982-06-08 |
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