PT3238707T - Composições e métodos para tratar a hiperpermeabilidade intestinal - Google Patents

Composições e métodos para tratar a hiperpermeabilidade intestinal

Info

Publication number
PT3238707T
PT3238707T PT171762313T PT17176231T PT3238707T PT 3238707 T PT3238707 T PT 3238707T PT 171762313 T PT171762313 T PT 171762313T PT 17176231 T PT17176231 T PT 17176231T PT 3238707 T PT3238707 T PT 3238707T
Authority
PT
Portugal
Prior art keywords
compositions
methods
treating intestinal
intestinal hyperpermeability
hyperpermeability
Prior art date
Application number
PT171762313T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Steve Hoffman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steve Hoffman filed Critical Steve Hoffman
Publication of PT3238707T publication Critical patent/PT3238707T/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
PT171762313T 2013-10-22 2014-10-21 Composições e métodos para tratar a hiperpermeabilidade intestinal PT3238707T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361894261P 2013-10-22 2013-10-22
US14/062,165 US20150111878A1 (en) 2013-10-22 2013-10-24 Compositions and methods for treating intestinal hyperpermeability

Publications (1)

Publication Number Publication Date
PT3238707T true PT3238707T (pt) 2021-04-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
PT171762313T PT3238707T (pt) 2013-10-22 2014-10-21 Composições e métodos para tratar a hiperpermeabilidade intestinal

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Country Link
US (1) US20150111878A1 (enExample)
EP (3) EP3238707B1 (enExample)
JP (3) JP2016538254A (enExample)
KR (1) KR20160093000A (enExample)
CN (2) CN113893239A (enExample)
AU (2) AU2014340303B2 (enExample)
CA (1) CA2925324A1 (enExample)
DK (1) DK3238707T3 (enExample)
ES (1) ES2865505T3 (enExample)
IL (2) IL244707B (enExample)
MX (1) MX2016004920A (enExample)
PH (3) PH12016500581A1 (enExample)
PL (1) PL3238707T3 (enExample)
PT (1) PT3238707T (enExample)
RS (1) RS61806B1 (enExample)
WO (1) WO2015061328A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10751313B2 (en) 2013-10-22 2020-08-25 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US9326962B2 (en) 2013-10-22 2016-05-03 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US10813901B2 (en) 2013-10-22 2020-10-27 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US9763903B2 (en) 2013-10-22 2017-09-19 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
AU2016247301A1 (en) * 2015-04-14 2017-10-26 Steven Hoffman Compositions and methods for treating autism
WO2017117158A1 (en) * 2015-12-28 2017-07-06 Steven Hoffman Methods of treating amyotrophic lateral sclerosis and symptoms thereof
KR102399254B1 (ko) * 2016-09-28 2022-05-17 아이거 바이오파마슈티컬스 인코포레이티드 비-알코올성 지방간염의 치료를 위한 방법 및 약제학적 조성물
KR102328323B1 (ko) 2017-03-31 2021-11-19 엑시얼 테라퓨틱스, 인크. 자폐증 및 관련 장애의 치료 및 예방을 위한 장-선택적 봉쇄제
KR20190138683A (ko) * 2017-04-21 2019-12-13 스티븐 호프만 망막병증을 치료하기 위한 조성물 및 방법
EP3431491A1 (en) * 2017-07-18 2019-01-23 Centre National De La Recherche Scientifique Methods for purifying proteins having a tubulin carboxypeptidase activity and peptidic based inhibitors thereof
KR20200038481A (ko) 2017-07-19 2020-04-13 호프만 테크놀로지스, 인크. 스트레스-관련 장애를 치료하기 위한 조성물
WO2019147934A1 (en) * 2018-01-29 2019-08-01 Sackner Bernstein Jonathan Methods for dopamine modulation in human neurologic diseases
JP2021530568A (ja) 2018-07-19 2021-11-11 ヤモ・ファーマシューティカルズ・エルエルシー 自閉症を処置するための組成物および方法
WO2020018292A1 (en) * 2018-07-19 2020-01-23 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
WO2020231909A1 (en) * 2019-05-11 2020-11-19 Steven Hoffman Compositions and methods for treating bile acid associated diseases
EP3968785A4 (en) 2019-05-14 2023-01-11 Tyme, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
WO2024059323A1 (en) * 2022-09-16 2024-03-21 Halas Francis Peter Low dose, sustained release formulation for alleviating symptoms caused by increased levels of dopamine and norepinephrine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056747A1 (en) * 1998-05-05 1999-11-11 Jose Pozuelo Compositions and methods for treating particular chemical addictions and mental illnesses
GB201020032D0 (en) * 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US9949923B2 (en) * 2011-03-15 2018-04-24 Optinose As Nasal delivery

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