PT2895509T - Recetores de células t que reconhecem mage-3 restrito a mhc de classe ii - Google Patents
Recetores de células t que reconhecem mage-3 restrito a mhc de classe iiInfo
- Publication number
- PT2895509T PT2895509T PT137672002T PT13767200T PT2895509T PT 2895509 T PT2895509 T PT 2895509T PT 137672002 T PT137672002 T PT 137672002T PT 13767200 T PT13767200 T PT 13767200T PT 2895509 T PT2895509 T PT 2895509T
- Authority
- PT
- Portugal
- Prior art keywords
- mhc class
- cell receptors
- receptors recognizing
- restricted mage
- recognizing mhc
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/7051—T-cell receptor (TcR)-CD3 complex
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261701056P | 2012-09-14 | 2012-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2895509T true PT2895509T (pt) | 2020-03-13 |
Family
ID=49253425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137672002T PT2895509T (pt) | 2012-09-14 | 2013-09-13 | Recetores de células t que reconhecem mage-3 restrito a mhc de classe ii |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US9879065B2 (OSRAM) |
| EP (3) | EP2895509B1 (OSRAM) |
| JP (4) | JP6461796B2 (OSRAM) |
| KR (4) | KR102303166B1 (OSRAM) |
| CN (2) | CN113754755A (OSRAM) |
| AU (4) | AU2013315391B2 (OSRAM) |
| CA (1) | CA2884743C (OSRAM) |
| CY (1) | CY1122720T1 (OSRAM) |
| DK (2) | DK2895509T3 (OSRAM) |
| ES (2) | ES2774931T3 (OSRAM) |
| HR (1) | HRP20200325T1 (OSRAM) |
| HU (1) | HUE048014T2 (OSRAM) |
| IL (3) | IL286786B (OSRAM) |
| LT (1) | LT2895509T (OSRAM) |
| MX (2) | MX367279B (OSRAM) |
| PL (1) | PL2895509T3 (OSRAM) |
| PT (1) | PT2895509T (OSRAM) |
| SI (1) | SI2895509T1 (OSRAM) |
| SM (1) | SMT202000103T1 (OSRAM) |
| WO (1) | WO2014043441A1 (OSRAM) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102303166B1 (ko) * | 2012-09-14 | 2021-09-17 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | Mhc ii형 제한된 mage-a3을 인식하는 t 세포 수용체 |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CN107075479A (zh) | 2014-10-02 | 2017-08-18 | 美国卫生和人力服务部 | 分离对癌症特异性突变具有抗原特异性的t细胞的方法 |
| US20170218042A1 (en) * | 2014-10-02 | 2017-08-03 | The United State of America, as represented by the Secretary, Department of Health and Human Service | Methods of isolating t cell receptors having antigenic specificity for a cancer-specific mutation |
| PH12021550850A1 (en) * | 2015-03-27 | 2022-10-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various tumors |
| GB201505305D0 (en) * | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| GB201515321D0 (en) * | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| WO2017070042A1 (en) | 2015-10-20 | 2017-04-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing t cell populations using akt inhibitors |
| WO2017139199A1 (en) | 2016-02-10 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible arginase |
| EP3416668A4 (en) | 2016-02-18 | 2020-02-19 | The Wistar Institute Of Anatomy And Biology | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MELANOMA |
| GB201604494D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers |
| GB201604458D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| EP4177264A1 (en) | 2016-03-16 | 2023-05-10 | Immatics Biotechnologies GmbH | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
| CN106749620B (zh) * | 2016-03-29 | 2020-09-25 | 广东香雪精准医疗技术有限公司 | 识别mage-a1抗原短肽的t细胞受体 |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| WO2018097951A1 (en) | 2016-11-22 | 2018-05-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mage-a3/a6 antibodies |
| DE102016123859B3 (de) | 2016-12-08 | 2018-03-01 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie |
| CN108250289B (zh) * | 2016-12-28 | 2021-10-08 | 香雪生命科学技术（广东）有限公司 | 源自于mage b6的肿瘤抗原短肽 |
| EP3565535A4 (en) | 2017-01-05 | 2020-12-30 | Fred Hutchinson Cancer Research Center | SYSTEMS AND METHODS FOR IMPROVING THE EFFECTIVENESS OF A VACCINE |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| FI3692140T3 (fi) * | 2017-10-05 | 2023-10-11 | Us Health | Menetelmiä solujen laajentamiseksi selektiivisesti ekspressoiden TCR:ää vakiolla muriinialueella |
| US20200316122A1 (en) | 2017-10-11 | 2020-10-08 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Methods of producing t cell populations using p38 mapk inhibitors |
| CN109776671B (zh) * | 2017-11-14 | 2022-05-27 | 杭州康万达医药科技有限公司 | 分离的t细胞受体、其修饰的细胞、编码核酸、表达载体、制备方法、药物组合物和应用 |
| CN109837248A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种tcr敲除的靶向mage-a3的t细胞受体基因修饰t细胞及其制备方法和应用 |
| CN109836490A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向mage-a3的t细胞受体、t细胞受体基因修饰t细胞及其制备方法和应用 |
| CN120154716A (zh) | 2018-01-22 | 2025-06-17 | 恩多塞特公司 | Car t细胞的使用方法 |
| JP7774961B2 (ja) | 2018-02-06 | 2025-11-25 | シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート | フルオレセイン結合エーテルリン脂質（ｆｌ－ｐｌｅ）で標識された腫瘍に対して最適なｔ細胞機能を示すフルオレセイン特異的ｃａｒ |
| CN118374524A (zh) | 2018-02-09 | 2024-07-23 | 美国卫生和人力服务部 | 拴系白细胞介素-15和白细胞介素-21 |
| CA3091674A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| JP7469807B2 (ja) | 2018-04-19 | 2024-04-17 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｍａｇｅ－ｂ２特異性を有するｔ細胞受容体およびその使用 |
| CN112262212B (zh) | 2018-04-24 | 2024-07-12 | 美国卫生和人力服务部 | 使用羟基柠檬酸和/或其盐产生t细胞群体的方法 |
| EP3714941A1 (en) * | 2019-03-27 | 2020-09-30 | Medigene Immunotherapies GmbH | Mage-a4 tcrs |
| CA3146845A1 (en) * | 2019-07-15 | 2021-01-21 | Neogene Therapeutics B.V. | Method to isolate tcr genes |
| DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
| JP2020143057A (ja) * | 2020-04-01 | 2020-09-10 | アメリカ合衆国 | がん特異的突然変異に対し抗原特異性を有するｔ細胞受容体を単離する方法 |
| EP4667936A2 (en) | 2020-09-08 | 2025-12-24 | The United States of America, as represented by the Secretary, Department of Health and Human Services | T cell phenotypes associated with response to adoptive cell therapy |
| US20240018210A1 (en) | 2020-11-13 | 2024-01-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Enhanced antigen reactivity of immune cells expressing a mutant non-signaling cd3 zeta chain |
| JP2025501259A (ja) | 2021-12-31 | 2025-01-17 | アメリカ合衆国 | がんに対する組合せ免疫療法としてのワクチン接種を伴うｔ細胞療法 |
| CN117946245B (zh) * | 2023-02-23 | 2024-08-02 | 暨南大学 | 一种识别mage-a3抗原短肽的t细胞受体及其应用 |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025160480A1 (en) | 2024-01-26 | 2025-07-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Enhanced tumor reactivity of t cells lacking sit1, lax1, or trat1 |
| WO2025250587A1 (en) | 2024-05-29 | 2025-12-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Drug-regulatable, inducible cytokine expression |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| IN165717B (OSRAM) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤 |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US20020197266A1 (en) | 2000-02-08 | 2002-12-26 | Waldemar Debinski | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| WO2012013913A1 (en) * | 2010-07-28 | 2012-02-02 | Immunocore Ltd | T cell receptors |
| EP2618835B1 (en) * | 2010-09-20 | 2017-07-05 | BioNTech Cell & Gene Therapies GmbH | Antigen-specific t cell receptors and t cell epitopes |
| WO2012054825A1 (en) | 2010-10-22 | 2012-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mage-a3 t cell receptors and related materials and methods of use |
| CN102251033B (zh) * | 2011-07-05 | 2013-03-20 | 北京大学人民医院 | 基于mage-a3基因辅助诊断多发性骨髓瘤患者的定量检测试剂盒 |
| SI2755997T1 (sl) | 2011-09-15 | 2018-11-30 | The United States of America, as represented by Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health | T-celični receptorji, ki prepoznajo HLA-A1- ali HLA-CW7-omejeni mage |
| US9413985B2 (en) * | 2012-09-12 | 2016-08-09 | Lattice Semiconductor Corporation | Combining video and audio streams utilizing pixel repetition bandwidth |
| KR102303166B1 (ko) * | 2012-09-14 | 2021-09-17 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | Mhc ii형 제한된 mage-a3을 인식하는 t 세포 수용체 |
-
2013
- 2013-09-13 KR KR1020207028713A patent/KR102303166B1/ko active Active
- 2013-09-13 CN CN202111028896.0A patent/CN113754755A/zh active Pending
- 2013-09-13 DK DK13767200.2T patent/DK2895509T3/da active
- 2013-09-13 MX MX2015003061A patent/MX367279B/es active IP Right Grant
- 2013-09-13 KR KR1020157006543A patent/KR102165350B1/ko active Active
- 2013-09-13 ES ES13767200T patent/ES2774931T3/es active Active
- 2013-09-13 KR KR1020227006700A patent/KR102480188B1/ko active Active
- 2013-09-13 IL IL286786A patent/IL286786B/en unknown
- 2013-09-13 EP EP13767200.2A patent/EP2895509B1/en active Active
- 2013-09-13 ES ES19212016T patent/ES2925307T3/es active Active
- 2013-09-13 JP JP2015532065A patent/JP6461796B2/ja active Active
- 2013-09-13 HU HUE13767200A patent/HUE048014T2/hu unknown
- 2013-09-13 CA CA2884743A patent/CA2884743C/en active Active
- 2013-09-13 CN CN201380059102.4A patent/CN104968675B/zh active Active
- 2013-09-13 EP EP19212016.0A patent/EP3636665B1/en active Active
- 2013-09-13 SM SM20200103T patent/SMT202000103T1/it unknown
- 2013-09-13 SI SI201331678T patent/SI2895509T1/sl unknown
- 2013-09-13 AU AU2013315391A patent/AU2013315391B2/en active Active
- 2013-09-13 WO PCT/US2013/059608 patent/WO2014043441A1/en not_active Ceased
- 2013-09-13 EP EP22174521.9A patent/EP4159753A1/en active Pending
- 2013-09-13 PL PL13767200T patent/PL2895509T3/pl unknown
- 2013-09-13 DK DK19212016.0T patent/DK3636665T3/da active
- 2013-09-13 PT PT137672002T patent/PT2895509T/pt unknown
- 2013-09-13 LT LTEP13767200.2T patent/LT2895509T/lt unknown
- 2013-09-13 US US14/427,671 patent/US9879065B2/en active Active
- 2013-09-13 KR KR1020217029207A patent/KR102370307B1/ko active Active
- 2013-09-13 HR HRP20200325TT patent/HRP20200325T1/hr unknown
-
2015
- 2015-03-04 IL IL237560A patent/IL237560B/en active IP Right Grant
- 2015-03-10 MX MX2019009641A patent/MX2019009641A/es unknown
-
2017
- 2017-08-23 AU AU2017219019A patent/AU2017219019B2/en active Active
- 2017-12-20 US US15/848,344 patent/US10611815B2/en active Active
-
2018
- 2018-12-26 JP JP2018243703A patent/JP6728326B2/ja active Active
-
2019
- 2019-08-06 AU AU2019213329A patent/AU2019213329B2/en active Active
-
2020
- 2020-03-03 CY CY20201100190T patent/CY1122720T1/el unknown
- 2020-03-09 US US16/812,845 patent/US20200270329A1/en not_active Abandoned
- 2020-04-16 IL IL274003A patent/IL274003B/en unknown
- 2020-07-01 JP JP2020114090A patent/JP6923714B2/ja active Active
-
2021
- 2021-06-07 AU AU2021203746A patent/AU2021203746B2/en active Active
- 2021-07-29 JP JP2021124003A patent/JP7270001B2/ja active Active
-
2022
- 2022-09-28 US US17/936,006 patent/US12404317B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL274003B (en) | T cell receptors that recognize mhc mage–a3 are restricted type ii | |
| IL290105A (en) | Mage-recognizing t cell receptors are restricted to 1hla–a or hla–cw7 | |
| EP2814104A4 (en) | ZINC RECHARGEABLE BATTERY | |
| IL235720A0 (en) | Murine anti-ny–eso–1 t-cell receptors | |
| SG11201510157YA (en) | T cell receptors | |
| ZA201600959B (en) | T cell receptors | |
| GB201213700D0 (en) | Receptor antagnists II | |
| AU347859S (en) | Battery | |
| AU346864S (en) | Battery | |
| GB201322430D0 (en) | T cell receptors | |
| GB201217406D0 (en) | Optical cell | |
| IL238745A0 (en) | Electrochemical separation device | |
| EP2939294A4 (en) | DRUMS | |
| EP2933324A4 (en) | DEVICE FOR DETACHING CELLS | |
| GB201223053D0 (en) | Receptor | |
| GB201218045D0 (en) | Battery | |
| GB201201418D0 (en) | T Cell receptors | |
| GB201218496D0 (en) | Cell | |
| TH1301006465B (th) | แบตเตอรี่ตะกั่ว | |
| GB201116427D0 (en) | T cell receptors | |
| GB201218046D0 (en) | Battery | |
| HUP1200355A2 (en) | Battery |