PT2744781T - Derivados de fentanilo como agonistas de receptores de opióides dependentes do ph - Google Patents
Derivados de fentanilo como agonistas de receptores de opióides dependentes do phInfo
- Publication number
- PT2744781T PT2744781T PT127534477T PT12753447T PT2744781T PT 2744781 T PT2744781 T PT 2744781T PT 127534477 T PT127534477 T PT 127534477T PT 12753447 T PT12753447 T PT 12753447T PT 2744781 T PT2744781 T PT 2744781T
- Authority
- PT
- Portugal
- Prior art keywords
- receptor agonists
- opioid receptor
- fentanyl derivatives
- dependent opioid
- dependent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11178122A EP2559685A1 (en) | 2011-08-19 | 2011-08-19 | Fentanyl derivatives as pH-dependent opioid receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2744781T true PT2744781T (pt) | 2018-01-16 |
Family
ID=46763055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127534477T PT2744781T (pt) | 2011-08-19 | 2012-08-17 | Derivados de fentanilo como agonistas de receptores de opióides dependentes do ph |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9133120B2 (pt) |
| EP (2) | EP2559685A1 (pt) |
| DK (1) | DK2744781T3 (pt) |
| ES (1) | ES2655646T3 (pt) |
| HR (1) | HRP20180048T1 (pt) |
| HU (1) | HUE037847T2 (pt) |
| NO (1) | NO2744781T3 (pt) |
| PL (1) | PL2744781T3 (pt) |
| PT (1) | PT2744781T (pt) |
| RS (1) | RS56734B1 (pt) |
| WO (1) | WO2013026787A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020006563A1 (en) * | 2018-06-29 | 2020-01-02 | Marquette University | Fluorinated compounds as ph-sensitive analgesics |
| CN113292485B (zh) * | 2021-06-08 | 2023-10-27 | 河南大学 | 苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用 |
| CN114949220B (zh) * | 2022-01-30 | 2023-09-22 | 浙江大学 | 一种靶向损伤节段背根神经节的pH响应镇痛药及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3923992A (en) * | 1974-05-23 | 1975-12-02 | Univ Mississippi | Analgetic composition and method of use |
| US6677332B1 (en) * | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
-
2011
- 2011-08-19 EP EP11178122A patent/EP2559685A1/en not_active Withdrawn
-
2012
- 2012-08-17 WO PCT/EP2012/066071 patent/WO2013026787A1/en active Application Filing
- 2012-08-17 US US14/239,461 patent/US9133120B2/en active Active
- 2012-08-17 NO NO12753447A patent/NO2744781T3/no unknown
- 2012-08-17 HU HUE12753447A patent/HUE037847T2/hu unknown
- 2012-08-17 ES ES12753447.7T patent/ES2655646T3/es active Active
- 2012-08-17 RS RS20180018A patent/RS56734B1/sr unknown
- 2012-08-17 DK DK12753447.7T patent/DK2744781T3/en active
- 2012-08-17 EP EP12753447.7A patent/EP2744781B1/en active Active
- 2012-08-17 PL PL12753447T patent/PL2744781T3/pl unknown
- 2012-08-17 PT PT127534477T patent/PT2744781T/pt unknown
-
2018
- 2018-01-10 HR HRP20180048TT patent/HRP20180048T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2744781T3 (en) | 2018-01-15 |
| RS56734B1 (sr) | 2018-03-30 |
| US20140228406A1 (en) | 2014-08-14 |
| EP2744781A1 (en) | 2014-06-25 |
| PL2744781T3 (pl) | 2018-05-30 |
| HRP20180048T1 (hr) | 2018-03-23 |
| WO2013026787A1 (en) | 2013-02-28 |
| NO2744781T3 (pt) | 2018-03-10 |
| EP2744781B1 (en) | 2017-10-11 |
| HUE037847T2 (hu) | 2018-09-28 |
| US9133120B2 (en) | 2015-09-15 |
| ES2655646T3 (es) | 2018-02-21 |
| EP2559685A1 (en) | 2013-02-20 |
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