PT2240431T - Modificações cristalinas de (1r,2r)-3-(3-dimetilamino-1- etil-2-metil-propil)fenol - Google Patents
Modificações cristalinas de (1r,2r)-3-(3-dimetilamino-1- etil-2-metil-propil)fenolInfo
- Publication number
- PT2240431T PT2240431T PT88572987T PT08857298T PT2240431T PT 2240431 T PT2240431 T PT 2240431T PT 88572987 T PT88572987 T PT 88572987T PT 08857298 T PT08857298 T PT 08857298T PT 2240431 T PT2240431 T PT 2240431T
- Authority
- PT
- Portugal
- Prior art keywords
- dimenthyl
- phenol
- propyl
- ethyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07023728 | 2007-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2240431T true PT2240431T (pt) | 2017-05-03 |
Family
ID=39272207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT162038483T PT3173400T (pt) | 2007-12-07 | 2008-12-05 | Modificações cristalinas de (1r, 2r)-3-(3-dimetilamino-1- etil-2-metil-propil)-fenol |
| PT88572987T PT2240431T (pt) | 2007-12-07 | 2008-12-05 | Modificações cristalinas de (1r,2r)-3-(3-dimetilamino-1- etil-2-metil-propil)fenol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT162038483T PT3173400T (pt) | 2007-12-07 | 2008-12-05 | Modificações cristalinas de (1r, 2r)-3-(3-dimetilamino-1- etil-2-metil-propil)-fenol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8134032B2 (pt) |
| EP (2) | EP2240431B1 (pt) |
| CN (3) | CN104447360B (pt) |
| CY (2) | CY1118976T1 (pt) |
| DK (2) | DK2240431T3 (pt) |
| ES (2) | ES2764451T3 (pt) |
| HR (2) | HRP20170481T1 (pt) |
| HU (2) | HUE031126T2 (pt) |
| IL (2) | IL206197A (pt) |
| LT (1) | LT2240431T (pt) |
| PL (2) | PL3173400T3 (pt) |
| PT (2) | PT3173400T (pt) |
| SI (2) | SI3173400T1 (pt) |
| WO (1) | WO2009071310A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100272815A1 (en) * | 2009-04-28 | 2010-10-28 | Actavis Group Ptc Ehf | Amorphous form of tapentadol hydrochloride |
| US8288592B2 (en) * | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
| US20130116333A1 (en) | 2010-05-05 | 2013-05-09 | Ratiopharm Gmbh | Solid tapentadol in non-crystalline form |
| WO2012051246A1 (en) | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
| WO2013111161A2 (en) * | 2012-01-10 | 2013-08-01 | Msn Laboratories Limited | Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof |
| WO2014023652A1 (en) * | 2012-08-06 | 2014-02-13 | Ratiopharm Gmbh | Pharmaceutical formulation comprising tapentadol and cyclodextrin |
| EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
| CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
| GB2523089A (en) * | 2014-02-12 | 2015-08-19 | Azad Pharmaceutical Ingredients Ag | Stable polymorph form B of tapentadol hydrochloride |
| PL3653599T3 (pl) | 2016-04-19 | 2023-03-20 | Ratiopharm Gmbh | Krystaliczny fosforan tapentadolu |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1027666C (zh) * | 1993-02-20 | 1995-02-15 | 袁晓辉 | 高分子聚合物正温度系数热敏电阻材料 |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| PE20030527A1 (es) * | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
| DE10326097A1 (de) * | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
| ATE368639T1 (de) * | 2004-06-28 | 2007-08-15 | Gruenenthal Gmbh | Kristalline formen von (-)-(1r,2r)-3-(3- dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochlorid |
| DE102005034974A1 (de) * | 2005-07-22 | 2007-04-19 | Grünenthal GmbH | Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen |
| US20070254960A1 (en) * | 2006-04-28 | 2007-11-01 | Gruenenthal Gmbh | Pharmaceutical combination |
-
2008
- 2008-12-05 SI SI200832101T patent/SI3173400T1/sl unknown
- 2008-12-05 US US12/329,111 patent/US8134032B2/en active Active
- 2008-12-05 EP EP08857298.7A patent/EP2240431B1/de active Active
- 2008-12-05 PT PT162038483T patent/PT3173400T/pt unknown
- 2008-12-05 HU HUE08857298A patent/HUE031126T2/en unknown
- 2008-12-05 PL PL16203848T patent/PL3173400T3/pl unknown
- 2008-12-05 WO PCT/EP2008/010330 patent/WO2009071310A1/de active Application Filing
- 2008-12-05 DK DK08857298.7T patent/DK2240431T3/en active
- 2008-12-05 CN CN201410468436.3A patent/CN104447360B/zh active Active
- 2008-12-05 LT LTEP08857298.7T patent/LT2240431T/lt unknown
- 2008-12-05 PT PT88572987T patent/PT2240431T/pt unknown
- 2008-12-05 SI SI200831791A patent/SI2240431T1/sl unknown
- 2008-12-05 DK DK16203848T patent/DK3173400T3/da active
- 2008-12-05 PL PL08857298T patent/PL2240431T3/pl unknown
- 2008-12-05 HU HUE16203848A patent/HUE047275T2/hu unknown
- 2008-12-05 ES ES16203848T patent/ES2764451T3/es active Active
- 2008-12-05 CN CN201410468681.4A patent/CN104447361B/zh active Active
- 2008-12-05 CN CN200880126383.XA patent/CN101939287B/zh active Active
- 2008-12-05 ES ES08857298.7T patent/ES2623413T3/es active Active
- 2008-12-05 EP EP16203848.3A patent/EP3173400B1/de active Active
-
2010
- 2010-06-06 IL IL206197A patent/IL206197A/en active IP Right Grant
-
2015
- 2015-03-01 IL IL237478A patent/IL237478A0/en unknown
-
2017
- 2017-03-21 HR HRP20170481TT patent/HRP20170481T1/hr unknown
- 2017-04-07 CY CY20171100414T patent/CY1118976T1/el unknown
-
2019
- 2019-12-04 CY CY20191101278T patent/CY1122416T1/el unknown
-
2020
- 2020-01-16 HR HRP20200067TT patent/HRP20200067T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2240431A1 (de) | 2010-10-20 |
| US8134032B2 (en) | 2012-03-13 |
| DK2240431T3 (en) | 2017-04-10 |
| HRP20170481T1 (hr) | 2017-05-19 |
| CN104447361B (zh) | 2017-04-12 |
| IL206197A (en) | 2015-03-31 |
| EP2240431B1 (de) | 2017-01-25 |
| PL2240431T3 (pl) | 2017-07-31 |
| PL3173400T3 (pl) | 2020-05-18 |
| CY1118976T1 (el) | 2018-01-10 |
| EP3173400A1 (de) | 2017-05-31 |
| PT3173400T (pt) | 2019-12-13 |
| CN104447360A (zh) | 2015-03-25 |
| CN104447360B (zh) | 2017-04-12 |
| SI3173400T1 (sl) | 2020-01-31 |
| EP3173400B1 (de) | 2019-11-06 |
| ES2623413T3 (es) | 2017-07-11 |
| CY1122416T1 (el) | 2021-01-27 |
| HRP20200067T1 (hr) | 2020-04-03 |
| HUE047275T2 (hu) | 2020-04-28 |
| CN101939287B (zh) | 2014-10-22 |
| WO2009071310A1 (de) | 2009-06-11 |
| DK3173400T3 (da) | 2019-11-25 |
| LT2240431T (lt) | 2017-04-10 |
| US20090149534A1 (en) | 2009-06-11 |
| ES2764451T3 (es) | 2020-06-03 |
| IL237478A0 (en) | 2015-04-30 |
| CN101939287A (zh) | 2011-01-05 |
| IL206197A0 (en) | 2010-12-30 |
| SI2240431T1 (sl) | 2017-05-31 |
| HUE031126T2 (en) | 2017-07-28 |
| CN104447361A (zh) | 2015-03-25 |
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