PT2191006E - Métodos para ensaiar a actividade enzimática de alfa-liduronidase - Google Patents

Métodos para ensaiar a actividade enzimática de alfa-liduronidase

Info

Publication number
PT2191006E
PT2191006E PT88277751T PT08827775T PT2191006E PT 2191006 E PT2191006 E PT 2191006E PT 88277751 T PT88277751 T PT 88277751T PT 08827775 T PT08827775 T PT 08827775T PT 2191006 E PT2191006 E PT 2191006E
Authority
PT
Portugal
Prior art keywords
methods
enzymatic activity
iduronidase enzymatic
assaying
alpha
Prior art date
Application number
PT88277751T
Other languages
English (en)
Inventor
Michael Gelb
Sophie Blanchard
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of PT2191006E publication Critical patent/PT2191006E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01076—L-Iduronidase (3.2.1.76)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT88277751T 2007-08-17 2008-08-18 Métodos para ensaiar a actividade enzimática de alfa-liduronidase PT2191006E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95664407P 2007-08-17 2007-08-17

Publications (1)

Publication Number Publication Date
PT2191006E true PT2191006E (pt) 2013-01-04

Family

ID=39929712

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88277751T PT2191006E (pt) 2007-08-17 2008-08-18 Métodos para ensaiar a actividade enzimática de alfa-liduronidase

Country Status (7)

Country Link
US (3) US8088745B2 (pt)
EP (1) EP2191006B1 (pt)
JP (1) JP2010536347A (pt)
ES (1) ES2396797T3 (pt)
PL (1) PL2191006T3 (pt)
PT (1) PT2191006E (pt)
WO (1) WO2009026252A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010536347A (ja) * 2007-08-17 2010-12-02 ユニヴァーシティ オブ ワシントン α−イズロニダーゼ酵素活性の検定のための方法
WO2012027612A1 (en) * 2010-08-25 2012-03-01 Michael Gelb Mass spectrometric compositions and methods for lysosomal storage disease screening
JP6180423B2 (ja) 2011-11-08 2017-08-16 ユニヴァーシティ オブ ワシントン リソソーム酵素アッセイ法および組成物
JP6128808B2 (ja) * 2011-11-15 2017-05-17 栄研化学株式会社 酵素活性の検出、測定方法およびこれを利用したキット
CN103487414A (zh) * 2012-06-14 2014-01-01 北京和信非凡生物技术有限公司 一种α-L-艾杜糖醛酸酶活性检测方法、底物和试剂
CN105636606B (zh) 2013-09-05 2021-03-12 华盛顿大学商业中心 用于筛查mps i、ii、iiia、iiib、iva、vi和vii的试剂和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69229174T2 (de) * 1991-08-23 1999-09-16 Molecular Probes Inc Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen
US5773236A (en) * 1997-04-25 1998-06-30 Molecule Probes, Inc. Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules
US5998593A (en) * 1998-03-10 1999-12-07 Abbott Laboratories Fluorescent enzyme substrates
EP1105517B2 (en) * 1998-08-25 2009-09-30 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
RU2392276C2 (ru) * 2005-03-29 2010-06-20 Ньюрон Фармасьютикалс С.П.А. Замещенные аминоалкил- и амидоалкилбензопиранпроизводные
JP2010536347A (ja) * 2007-08-17 2010-12-02 ユニヴァーシティ オブ ワシントン α−イズロニダーゼ酵素活性の検定のための方法

Also Published As

Publication number Publication date
US20150353985A1 (en) 2015-12-10
US9012663B2 (en) 2015-04-21
JP2010536347A (ja) 2010-12-02
EP2191006A1 (en) 2010-06-02
EP2191006B1 (en) 2012-11-21
US20120052519A1 (en) 2012-03-01
US9790536B2 (en) 2017-10-17
ES2396797T3 (es) 2013-02-27
PL2191006T3 (pl) 2013-05-31
WO2009026252A1 (en) 2009-02-26
US20100209951A1 (en) 2010-08-19
US8088745B2 (en) 2012-01-03

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