PT2155248E - Targeting abcb5 for cancer therapy - Google Patents

Targeting abcb5 for cancer therapy Download PDF

Info

Publication number
PT2155248E
PT2155248E PT87427878T PT08742787T PT2155248E PT 2155248 E PT2155248 E PT 2155248E PT 87427878 T PT87427878 T PT 87427878T PT 08742787 T PT08742787 T PT 08742787T PT 2155248 E PT2155248 E PT 2155248E
Authority
PT
Portugal
Prior art keywords
cancer therapy
abcb5
targeting
targeting abcb5
cancer
Prior art date
Application number
PT87427878T
Other languages
Portuguese (pt)
Inventor
Markus H Frank
Natasha Y Frank
Mohamed H Sayegh
Original Assignee
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital filed Critical Brigham & Womens Hospital
Publication of PT2155248E publication Critical patent/PT2155248E/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/02—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
    • C12Y302/02022—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2) rRNA N-glycosylase (3.2.2.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
PT87427878T 2007-04-12 2008-04-11 Targeting abcb5 for cancer therapy PT2155248E (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92312807P 2007-04-12 2007-04-12
US705907P 2007-12-11 2007-12-11

Publications (1)

Publication Number Publication Date
PT2155248E true PT2155248E (en) 2015-10-23

Family

ID=39661432

Family Applications (2)

Application Number Title Priority Date Filing Date
PT87427878T PT2155248E (en) 2007-04-12 2008-04-11 Targeting abcb5 for cancer therapy
PT13163810T PT2644205T (en) 2007-04-12 2008-04-11 Targeting abcb5 for cancer therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT13163810T PT2644205T (en) 2007-04-12 2008-04-11 Targeting abcb5 for cancer therapy

Country Status (15)

Country Link
US (4) US7928202B2 (en)
EP (3) EP2644205B1 (en)
JP (4) JP5889527B2 (en)
AU (1) AU2008239633B2 (en)
CA (1) CA2718573C (en)
CY (2) CY1116823T1 (en)
DK (2) DK2644205T3 (en)
ES (2) ES2687270T3 (en)
HR (2) HRP20150934T1 (en)
HU (2) HUE027593T2 (en)
LT (1) LT2644205T (en)
PL (2) PL2155248T3 (en)
PT (2) PT2155248E (en)
SI (2) SI2644205T1 (en)
WO (1) WO2008127656A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338756T3 (en) 2000-06-05 2010-05-12 The Brigham And Women's Hospital, Inc. A GENE THAT CODIFIES A MULTIPHARMACO-RESISTANT HUMAN GLICOPROTEIN P HOMOLOGY IN CHROMOSOME 7P15-21 AND USES OF THE SAME.
DK2772535T3 (en) * 2006-05-31 2022-07-04 Childrens Medical Center ABC5-positive mesenchymal stem cells as immune modulators
SI2644205T1 (en) 2007-04-12 2018-11-30 The Brigham And Women's Hospital, Inc. Targeting ABCB5 for cancer therapy
WO2010056332A1 (en) * 2008-11-14 2010-05-20 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
WO2010065711A1 (en) * 2008-12-04 2010-06-10 Adimab, Inc. An abcb5 epitope and antibodies thereto for the treatment of cancer
EP2569011A4 (en) * 2010-05-14 2013-06-12 Univ Hong Kong Gep antibody and uses thereof
EP3865573A1 (en) 2013-02-19 2021-08-18 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
CN105517587B (en) 2013-05-10 2019-02-19 儿童医学中心公司 Wound healing and organizational project
US9177410B2 (en) 2013-08-09 2015-11-03 Ayla Mandel System and method for creating avatars or animated sequences using human body features extracted from a still image
US20180134771A1 (en) * 2015-05-07 2018-05-17 Bioxcel Corporation Novel immunomodulatory therapeutic strategies targeting tumors in cancer
NZ739503A (en) 2015-07-16 2023-06-30 Bioxcel Therapeutics Inc A novel approach for treatment of cancer using immunomodulation
SG11202010260XA (en) * 2018-04-25 2020-11-27 Childrens Medical Center Abcb5 ligands and substrates
JP2023522047A (en) * 2020-04-15 2023-05-26 ザ チルドレンズ メディカル センター コーポレーション Targeting of ABCB5 in glioblastoma multiforme
EP4142793A1 (en) * 2020-04-30 2023-03-08 Children's Medical Center Corporation Antibodies specific to abcb5 and uses thereof
CN116836291B (en) * 2023-08-25 2023-11-07 宝船生物医药科技(上海)有限公司 Anti-idiotype antibody of anti-CD 47-CLDN18.2 bispecific antibody, preparation method and application thereof

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US565354A (en) 1896-08-04 James h
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
BR7908937A (en) * 1978-12-06 1981-06-30 Svedman Paul DEVICE FOR TREATING FABRICS, FOR EXAMPLE, SKIN
US4355023A (en) 1980-09-30 1982-10-19 The Massachusetts General Hospital Antibody fragment compositions and process
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4470925A (en) 1982-05-05 1984-09-11 E. I. Du Pont De Nemours And Company Immunoglobulin half-molecules and process for producing hybrid antibodies
US4462334A (en) 1982-08-19 1984-07-31 Kim Ho K Solar animal structure
AT379688B (en) * 1982-11-22 1986-02-10 List Hans SENSOR ELEMENT FOR DETERMINING THE O2 CONTENT OF A SAMPLE
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
DE3587465T2 (en) 1984-09-10 1994-01-20 Hsc Res Dev Corp Multiple drug resistance in mammalian cell lines and isolation of determinant glycoprotein DNA.
US4837306A (en) 1985-02-25 1989-06-06 The Ontario Cancer Institute Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen
GB8509978D0 (en) * 1985-04-18 1985-05-30 Juhasz L Wound dressings
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5567610A (en) * 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5565354A (en) * 1986-09-05 1996-10-15 Sandoz Ltd. Production of human monoclonal antibodies specific for hepatitis B surface antigen
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5053394A (en) 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US5606040A (en) 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
EP0435911B1 (en) 1988-09-23 1996-03-13 Cetus Oncology Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5399483A (en) * 1989-03-30 1995-03-21 Suntory Limited Expression of MDR-related gene in yeast cell
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
ES2246502T3 (en) * 1990-08-29 2006-02-16 Genpharm International, Inc. TRANSGENIC NON-HUMAN ANIMALS ABLE TO PRODUCE HETEROLOGICAL ANTIBODIES.
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5434075A (en) 1992-03-20 1995-07-18 Board Of Trustees Of The University Of Illinois Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
CA2122732C (en) 1991-11-25 2008-04-08 Marc D. Whitlow Multivalent antigen-binding proteins
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US6436078B1 (en) * 1994-12-06 2002-08-20 Pal Svedman Transdermal perfusion of fluids
CA2128862C (en) 1992-02-11 2008-05-20 Jonathan G. Seidman Homogenotization of gene-targeting events
US6231881B1 (en) * 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
IT1257893B (en) 1992-06-17 1996-02-16 Ist Superiore Sanita MONOCLONAL ANTIBODIES THAT RECOGNIZE AN EPITOPE OF HUMAN P-GLYCOPROTEIN.
ES2091684T3 (en) 1992-11-13 1996-11-01 Idec Pharma Corp THERAPEUTIC APPLICATION OF CHEMICAL AND RADIO-MARKED ANTIBODIES AGAINST THE RESTRICTED DIFFERENTIATION ANTIGEN OF HUMAN B-LYMPHOCYTES FOR THE TREATMENT OF B-CELL LYMPHOMA.
GB2272645B8 (en) * 1992-11-23 2010-02-10 Johnson & Johnson Medical Wound dressing
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
EP0740791A4 (en) 1994-01-05 2000-04-05 Arqule Inc Systematic modular production of aminimide- and oxazolone-based molecules having selected properties
GB9403135D0 (en) * 1994-02-18 1994-04-06 Univ Glasgow Wound healing device
EP0804249A2 (en) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeric gene delivery system
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
EP0922666B1 (en) * 1996-06-28 2004-09-08 Matsushita Electric Works, Ltd. Reforming apparatus for making a CO-reduced reformed gas.
US5904659A (en) * 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
US6152142A (en) 1997-02-28 2000-11-28 Tseng; Scheffer C. G. Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
DE19722075C1 (en) * 1997-05-27 1998-10-01 Wilhelm Dr Med Fleischmann Medication supply to open wounds
US6420622B1 (en) * 1997-08-01 2002-07-16 3M Innovative Properties Company Medical article having fluid control film
US6071267A (en) * 1998-02-06 2000-06-06 Kinetic Concepts, Inc. Medical patient fluid management interface system and method
PT1068241E (en) 1998-04-02 2007-11-19 Genentech Inc Antibody variants and fragments thereof
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
JP4220058B2 (en) * 1998-06-30 2009-02-04 浜松ホトニクス株式会社 Semiconductor position detector
WO2000047129A2 (en) * 1999-02-11 2000-08-17 The General Hospital Corporation Microfabricated membranes and matrices
US6277574B1 (en) * 1999-04-09 2001-08-21 Incyte Genomics, Inc. Genes associated with diseases of the kidney
ATE400315T1 (en) * 1999-11-29 2008-07-15 Hill Rom Services Inc DEVICE FOR TREATING A WOUND
PT1309726E (en) 2000-03-30 2010-03-08 Whitehead Biomedical Inst Rna sequence-specific mediators of rna interference
ES2338756T3 (en) 2000-06-05 2010-05-12 The Brigham And Women's Hospital, Inc. A GENE THAT CODIFIES A MULTIPHARMACO-RESISTANT HUMAN GLICOPROTEIN P HOMOLOGY IN CHROMOSOME 7P15-21 AND USES OF THE SAME.
WO2001096361A1 (en) * 2000-06-12 2001-12-20 University Of Maryland Biotechnology Institute Method of controlling the binding of calmyrin to presenilin
DK1292680T3 (en) 2000-06-22 2010-03-08 Genentech Inc Agonist-anti-TrkC monoclonal antibodies
AU2002211389A1 (en) * 2000-10-03 2002-04-15 California Institute Of Technology Microfluidic devices and methods of use
CA2427010A1 (en) 2000-10-27 2002-05-23 Incyte Genomics, Inc. Transporters and ion channels
US6685681B2 (en) * 2000-11-29 2004-02-03 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US6855135B2 (en) * 2000-11-29 2005-02-15 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US8015677B2 (en) 2000-12-01 2011-09-13 Aard-Balm Limited Embalming fluid
EP1350029B1 (en) * 2001-01-08 2014-09-10 President and Fellows of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
WO2002062968A2 (en) * 2001-02-02 2002-08-15 The Regents Of The University Of Michigan Micro-tubular materials and cell constructs
US6695824B2 (en) * 2001-04-16 2004-02-24 The United States Of America As Represented By The Secretary Of The Army Wound dressing system
CA2468309A1 (en) * 2001-12-26 2003-07-17 Robert Petrosenko Wound vacuum therapy dressing kit
WO2003057070A2 (en) * 2001-12-26 2003-07-17 Hill-Rom Services Inc. Vented vacuum bandage and method
US8034904B2 (en) * 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
AU2003247762B2 (en) * 2002-07-03 2008-05-01 Immunogen, Inc. Antibodies to non-shed MUC1 and MUC16, and uses thereof
JP4409430B2 (en) 2002-07-03 2010-02-03 小野薬品工業株式会社 Immunostimulatory composition
DK1578446T3 (en) * 2002-11-07 2015-06-29 Immunogen Inc ANTI-CD33 ANTIBODIES AND PROCEDURES FOR TREATING ACUTE MYELOID LEUKEMIA BY USING IT
CN1753912B (en) 2002-12-23 2011-11-02 惠氏公司 Antibodies against PD-1 and uses therefor
CA2528669A1 (en) 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
GB0325130D0 (en) 2003-10-28 2003-12-03 Smith & Nephew Apparatus with scaffold
US7829336B2 (en) 2003-11-24 2010-11-09 The Rockefeller University Method for isolating a self-renewing, multipotent, slow-cycling cell
HUE026132T2 (en) 2004-01-07 2016-05-30 Novartis Vaccines & Diagnostics Inc M-csf-specific monoclonal antibody and uses thereof
US7364592B2 (en) * 2004-02-12 2008-04-29 Dexcom, Inc. Biointerface membrane with macro-and micro-architecture
GB0416168D0 (en) * 2004-07-20 2004-08-18 Vernalis Cambridge Ltd Pyrmidothiophene compounds
US10538742B2 (en) 2004-11-12 2020-01-21 Cambridge Enterprise Limited Methods and means related to cancer stem cells
WO2006135886A2 (en) 2005-06-13 2006-12-21 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
AU2006259583A1 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
DK2772535T3 (en) 2006-05-31 2022-07-04 Childrens Medical Center ABC5-positive mesenchymal stem cells as immune modulators
CA2698597A1 (en) * 2006-09-07 2008-03-13 Stemline Therapeutics, Inc. Monitoring cancer stem cells
SI2644205T1 (en) * 2007-04-12 2018-11-30 The Brigham And Women's Hospital, Inc. Targeting ABCB5 for cancer therapy
WO2010056332A1 (en) * 2008-11-14 2010-05-20 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
EP3865573A1 (en) 2013-02-19 2021-08-18 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
CN105517587B (en) 2013-05-10 2019-02-19 儿童医学中心公司 Wound healing and organizational project

Also Published As

Publication number Publication date
JP6268237B2 (en) 2018-01-24
EP2644205B1 (en) 2018-06-13
DK2644205T3 (en) 2018-09-24
DK2155248T3 (en) 2015-09-14
ES2547016T3 (en) 2015-09-30
EP2155248B1 (en) 2015-06-10
HUE039385T2 (en) 2018-12-28
HUE027593T2 (en) 2016-11-28
HRP20181385T1 (en) 2018-10-19
US20140302031A1 (en) 2014-10-09
JP2014133770A (en) 2014-07-24
HRP20150934T1 (en) 2015-11-06
JP2016188248A (en) 2016-11-04
SI2644205T1 (en) 2018-11-30
US7928202B2 (en) 2011-04-19
CA2718573C (en) 2020-07-14
AU2008239633B2 (en) 2014-05-29
EP2155248A1 (en) 2010-02-24
US9266946B2 (en) 2016-02-23
EP3431103A1 (en) 2019-01-23
JP6530044B2 (en) 2019-06-12
PL2644205T3 (en) 2018-11-30
EP2644205A1 (en) 2013-10-02
SI2155248T1 (en) 2015-12-31
PL2155248T3 (en) 2015-12-31
AU2008239633A1 (en) 2008-10-23
WO2008127656A1 (en) 2008-10-23
US8697072B2 (en) 2014-04-15
US20110165149A1 (en) 2011-07-07
CY1121046T1 (en) 2019-12-11
CY1116823T1 (en) 2017-03-15
US9855342B2 (en) 2018-01-02
JP5889527B2 (en) 2016-03-22
US20160136297A1 (en) 2016-05-19
PT2644205T (en) 2018-10-19
JP2010534191A (en) 2010-11-04
JP2018052979A (en) 2018-04-05
EP3431103B1 (en) 2021-07-28
CA2718573A1 (en) 2008-10-23
LT2644205T (en) 2018-12-10
ES2687270T3 (en) 2018-10-24
US20090117117A1 (en) 2009-05-07

Similar Documents

Publication Publication Date Title
HRP20181385T1 (en) Targeting abcb5 for cancer therapy
ZA201004403B (en) Therapeutic cancer treatments
EP2318040A4 (en) Therapy targeting cancer stem cells
HK1185414A1 (en) Drug selection for breast cancer therapy using antibody-based arrays
EP2303337A4 (en) Small molecule ligand-drug conjugates for targeted cancer therapy
HK1201724A1 (en) Cancer stem cell-targeted cancer therapy
EP2127671A4 (en) Therapeutic agent for cancer
IL215764A0 (en) Adjuvant cancer therapy
IL199992A0 (en) Combination therapy
HK1147684A1 (en) Targeted radiotherapy
GB0719518D0 (en) Therapy
EP2211863A4 (en) Combination therapy
GB0707556D0 (en) Treatment for cancer
EP2099303A4 (en) Therapeutic tetrahydroisoquinoline-based compositions for cancer therapy
GB0700284D0 (en) Combination therapy
GB0809046D0 (en) Cancer treatment
PT2305654E (en) Therapeutic agent for cancer pain
GB0716072D0 (en) Therapy
GB0700635D0 (en) Therapy
GB0706538D0 (en) Cancer therapeutic
IL210247A0 (en) Ccl20 - specific antibodies for cancer therapy
GB0612259D0 (en) Cancer therapeutic
GB0606702D0 (en) Cancer therapeutic
AU2008902090A0 (en) Cancer Therapy
GB0921102D0 (en) Cancer Therapy