PT1932918E - Método para a produção de cladribina - Google Patents

Método para a produção de cladribina Download PDF

Info

Publication number
PT1932918E
PT1932918E PT06026046T PT06026046T PT1932918E PT 1932918 E PT1932918 E PT 1932918E PT 06026046 T PT06026046 T PT 06026046T PT 06026046 T PT06026046 T PT 06026046T PT 1932918 E PT1932918 E PT 1932918E
Authority
PT
Portugal
Prior art keywords
cladribine
reaction medium
production
reaction
phosphorylase
Prior art date
Application number
PT06026046T
Other languages
English (en)
Inventor
Gabriele Zuffi
Simone Monciardini
Original Assignee
Explora Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Explora Lab Sa filed Critical Explora Lab Sa
Publication of PT1932918E publication Critical patent/PT1932918E/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/38Nucleosides
    • C12P19/40Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/40Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT06026046T 2006-12-15 2006-12-15 Método para a produção de cladribina PT1932918E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026046A EP1932918B1 (en) 2006-12-15 2006-12-15 Method for the production of cladribine

Publications (1)

Publication Number Publication Date
PT1932918E true PT1932918E (pt) 2010-01-05

Family

ID=38038673

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06026046T PT1932918E (pt) 2006-12-15 2006-12-15 Método para a produção de cladribina

Country Status (9)

Country Link
US (1) US8012717B2 (pt)
EP (1) EP1932918B1 (pt)
AT (1) ATE443151T1 (pt)
CA (1) CA2610862A1 (pt)
DE (1) DE602006009282D1 (pt)
ES (1) ES2335796T3 (pt)
PL (1) PL1932918T3 (pt)
PT (1) PT1932918E (pt)
SI (1) SI1932918T1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232387B2 (en) * 2009-08-18 2012-07-31 Scinopharm Taiwan, Ltd. Process for the preparation of cladribine
EP2993177A1 (en) 2014-09-05 2016-03-09 Technische Universität Berlin A chemo-enzymatic preparation method for purine nucleosides and their deaza- and aza- analogues
CN106929553B (zh) * 2015-12-31 2021-02-19 上海鑫欣生物科技有限公司 一种酶法合成阿糖腺苷的方法
CN110945086B (zh) * 2017-06-30 2022-09-16 陶氏环球技术有限责任公司 用于清除醛的涂层及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (en) 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US5208327A (en) 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US6252061B1 (en) 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US20020052491A1 (en) 1999-04-28 2002-05-02 Szepsel Gerszberg Method for the production of 2-chloro-2' -deoxyadenosine (cladribine) and its 3,5-di-O-p-toluoyl derivative
EP1178051B1 (en) 2000-02-10 2008-05-28 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
US6884880B2 (en) 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
US7572909B2 (en) 2002-09-25 2009-08-11 Brigham Young University Method for the preparation of 2-halo-2′-deoxyadenosine compounds from 2′-deoxyguanosine
SI1439220T1 (sl) * 2003-01-16 2007-12-31 Adorkem Technology Spa Imobilizirani biokatalizatorji, uporabnimi za izdelavo naravnih nukleozidov in modificiranih analogov z encimatskimi reakcijami transglikolizacije

Also Published As

Publication number Publication date
US20100291632A1 (en) 2010-11-18
ATE443151T1 (de) 2009-10-15
US8012717B2 (en) 2011-09-06
CA2610862A1 (en) 2008-06-15
EP1932918A1 (en) 2008-06-18
EP1932918B1 (en) 2009-09-16
DE602006009282D1 (de) 2009-10-29
SI1932918T1 (sl) 2010-02-26
ES2335796T3 (es) 2010-04-05
PL1932918T3 (pl) 2010-03-31

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