PT1519748E - Micropartículas com anticorpos monoclonais específicos de cd28 - Google Patents

Micropartículas com anticorpos monoclonais específicos de cd28 Download PDF

Info

Publication number
PT1519748E
PT1519748E PT03762386T PT03762386T PT1519748E PT 1519748 E PT1519748 E PT 1519748E PT 03762386 T PT03762386 T PT 03762386T PT 03762386 T PT03762386 T PT 03762386T PT 1519748 E PT1519748 E PT 1519748E
Authority
PT
Portugal
Prior art keywords
monoclonal antibodies
microparticle
specific monoclonal
support structure
specific
Prior art date
Application number
PT03762386T
Other languages
English (en)
Inventor
Thomas Huenig
Original Assignee
Theramab Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramab Llc filed Critical Theramab Llc
Publication of PT1519748E publication Critical patent/PT1519748E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT03762386T 2002-07-04 2003-05-30 Micropartículas com anticorpos monoclonais específicos de cd28 PT1519748E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10230223A DE10230223A1 (de) 2002-07-04 2002-07-04 Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern

Publications (1)

Publication Number Publication Date
PT1519748E true PT1519748E (pt) 2009-12-24

Family

ID=29761657

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03762386T PT1519748E (pt) 2002-07-04 2003-05-30 Micropartículas com anticorpos monoclonais específicos de cd28

Country Status (9)

Country Link
US (1) US7868143B2 (pt)
EP (1) EP1519748B1 (pt)
AT (1) ATE442860T1 (pt)
AU (1) AU2003243914A1 (pt)
DE (2) DE10230223A1 (pt)
DK (1) DK1519748T3 (pt)
ES (1) ES2333790T3 (pt)
PT (1) PT1519748E (pt)
WO (1) WO2004004768A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1460088A1 (en) * 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
US7435592B2 (en) 2003-05-13 2008-10-14 Immunovative Therapies, Ltd. Compositions for allogeneic cell therapy
GB0400440D0 (en) 2004-01-09 2004-02-11 Isis Innovation Receptor modulators
CA2555714C (en) 2004-02-26 2013-12-03 Immunovative Therapies, Ltd. Methods for preparing t-cells for cell therapy
US7592431B2 (en) * 2004-02-26 2009-09-22 Immunovative Therapies, Ltd. Biodegradable T-cell Activation device
ES2437571T3 (es) * 2004-11-11 2014-01-13 Theramab Llc Anticuerpos anti-CD28 superagonistas
DE102005022319A1 (de) * 2005-05-10 2006-11-23 Symbiotec Gesellschaft Zur Forschung Und Entwicklung Auf Dem Gebiet Der Biotechnologie Mbh Verwendung von Histonen zu therapeutischen Zwecken
US7585960B2 (en) 2005-05-11 2009-09-08 Theramab Gmbh Nucleic acids encoding superagonistic anti-CD28 antibodies
JP5795167B2 (ja) * 2008-03-13 2015-10-14 バイオテスト・アクチエンゲゼルシヤフト 疾患治療剤
SG190627A1 (en) * 2008-03-13 2013-06-28 Biotest Ag Agent for treating disease
CN102027017A (zh) * 2008-03-13 2011-04-20 生物测试股份公司 一种治疗疾病的试剂
US9176122B2 (en) * 2008-03-24 2015-11-03 University Of South Florida Biomarkers for predicting response to immunosuppressive therapy
KR20110061630A (ko) * 2008-09-29 2011-06-09 바이오테스트 아게 질병 치료용 조성물
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
US9233156B2 (en) 2011-05-03 2016-01-12 Immunovative Therapies Ltd. Induction of IL-12 using immunotherapy
CA2838041C (en) 2011-05-03 2018-09-25 Immunovative Therapies, Ltd. Methods for handling biological drugs containing living cells
EP2886645A1 (en) 2013-12-20 2015-06-24 Julius-Maximilians-Universität Würzburg Expansion of human T cells in vitro by bead-bound conventional anti-CD28 monoclonal antibodies
WO2019241730A2 (en) 2018-06-15 2019-12-19 Flagship Pioneering Innovations V, Inc. Increasing immune activity through modulation of postcellular signaling factors
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
EP4076434A1 (en) 2019-12-17 2022-10-26 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
CN116096906A (zh) 2020-06-29 2023-05-09 旗舰创业创新五公司 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途
US20220325287A1 (en) 2021-03-31 2022-10-13 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
WO2023278641A1 (en) 2021-06-29 2023-01-05 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19722888A1 (de) * 1997-05-28 1998-12-03 Thomas Prof Dr Huenig Human-CD28 spezifische monoklonale Antikörper zur antigenunspezifischen Aktivierung von T-Lymphozyten
ATE373078T1 (de) 2000-02-24 2007-09-15 Xcyte Therapies Inc Gleichzeitige stimulation und konzentration von zellen
DE10050935A1 (de) * 2000-10-11 2002-05-02 Tegenero Gmbh Verwendung CD28 spezifischer monoklonaler Antikörper zur Stimulation von Blutzellen, welche kein CD28 tragen

Also Published As

Publication number Publication date
US7868143B2 (en) 2011-01-11
ATE442860T1 (de) 2009-10-15
US20060121021A1 (en) 2006-06-08
WO2004004768A1 (de) 2004-01-15
AU2003243914A1 (en) 2004-01-23
DE50311921D1 (de) 2009-10-29
EP1519748A1 (de) 2005-04-06
ES2333790T3 (es) 2010-03-01
DE10230223A1 (de) 2004-01-22
DK1519748T3 (da) 2010-01-18
EP1519748B1 (de) 2009-09-16

Similar Documents

Publication Publication Date Title
PT1519748E (pt) Micropartículas com anticorpos monoclonais específicos de cd28
HK1081647A1 (en) N-11 truncated amyloid-beta monoclonal antibodies, compositions, methods and uses
WO2003078468A3 (de) Verwendung einer an cd28 bindenden wirksubstanz zur herstellung einer pharmazeutischen zusammensetzung
AU2003265883A8 (en) Monoclonal antibodies and complementarity-determining regions binding to ebola glycoprotein
HK1077226A1 (en) Human monoclonal antibodies against cd25
EP1539947A4 (en) HUMANIZED RABBIT ANTIBODIES
SG135207A1 (en) Anti-il-13 antibodies, crystals of anti-il-13 antibodies and complexes comprising them
WO2006066568A3 (de) Monokonale agonistische anti-ctla-4 antikörper
CY2012019I1 (el) Ανθρωπινα μονοκλωνα αντισωματα εναντια στο cd20
HK1078589A1 (en) Anti-human tenascin monoclonal antibody
EP1391464A4 (en) ANTI-CD40 MONOCLONAL ANTIBODY
HK1085222A1 (en) Humanized antibodies that recognize beta amyloid peptide
IL184152A0 (en) Monoclonal antibodies against nkg2a
EP1607404A4 (en) MONOCLONAL ANTIBODY AND HYBRIDOM THAT PRODUCES THIS
EP1647596A4 (en) MONOCLONAL ANTIBODY AGAINST GLYCOPROTEIN VI THE BLOOD PLATE MEMBRANE
EP1539793A4 (en) HUMANIZED ANTIBODIES AGAINST THE RECEPTOR OF LYMPHOTOXIN BETA
UA94211C2 (ru) Выделенное полностью человеческое моноклональное cd3 антитело
AU2003285540A8 (en) Antibody for the thyrotropin receptor and uses thereof
EP1476469A4 (en) MONOCLONAL ANTIBODIES TO EXTRACELLULAR GRINDINGS OF C5Ar
EP1567555A4 (en) HUMANIZED ANTIBODIES AGAINST CHEMOTOXIC MONOCYTE PROTEINS
WO2006029220A3 (en) Combination therapy with anti-ctla4 and anti-4-1bb antibodies
AU2003275834A1 (en) ANTIBODIES THAT BIND alphaE INTEGRIN
AU2003210054A1 (en) Anti-rank monoclonal antibodies and pharmaceutical composition containing the same
AU2003229799A1 (en) Novel humanized anti-vap-1 monoclonal antibody
FI20011055A (fi) Heveiiniä sitovat monoklonaaliset vasta-aineet