PT1374865E - Utilizacao de acido r,s(+/-)-alfa-lipoico, acido r-(+)-alfa-lipoico ou acido s-(-)-alfa-lipoico na forma reduzida ou oxidada para o tratamento de disturbios auditivos - Google Patents

Utilizacao de acido r,s(+/-)-alfa-lipoico, acido r-(+)-alfa-lipoico ou acido s-(-)-alfa-lipoico na forma reduzida ou oxidada para o tratamento de disturbios auditivos

Info

Publication number
PT1374865E
PT1374865E PT03018232T PT03018232T PT1374865E PT 1374865 E PT1374865 E PT 1374865E PT 03018232 T PT03018232 T PT 03018232T PT 03018232 T PT03018232 T PT 03018232T PT 1374865 E PT1374865 E PT 1374865E
Authority
PT
Portugal
Prior art keywords
alpha
lipoic acid
treatment
blood
prevention
Prior art date
Application number
PT03018232T
Other languages
English (en)
Inventor
Frank Conrad
Heinz Ulrich
Hermann-August Henrich
Wolfgang Dr Geise
Original Assignee
Viatris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viatris Gmbh filed Critical Viatris Gmbh
Publication of PT1374865E publication Critical patent/PT1374865E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
PT03018232T 1994-11-08 1995-10-31 Utilizacao de acido r,s(+/-)-alfa-lipoico, acido r-(+)-alfa-lipoico ou acido s-(-)-alfa-lipoico na forma reduzida ou oxidada para o tratamento de disturbios auditivos PT1374865E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4439477A DE4439477C2 (de) 1994-11-08 1994-11-08 Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie

Publications (1)

Publication Number Publication Date
PT1374865E true PT1374865E (pt) 2005-09-30

Family

ID=6532519

Family Applications (2)

Application Number Title Priority Date Filing Date
PT03018232T PT1374865E (pt) 1994-11-08 1995-10-31 Utilizacao de acido r,s(+/-)-alfa-lipoico, acido r-(+)-alfa-lipoico ou acido s-(-)-alfa-lipoico na forma reduzida ou oxidada para o tratamento de disturbios auditivos
PT95117108T PT712626E (pt) 1994-11-08 1995-10-31 Utilizacao de acido r,s-(+/-)-alfa-lipoico, acido r-(+)-alfa-lipoico, acido s-(-)-alfa-lipoico na forma reduzida ou oxidada ou dos metabolitos assim como sais, esteres, amidas destes para a preparacao de agentes reologicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT95117108T PT712626E (pt) 1994-11-08 1995-10-31 Utilizacao de acido r,s-(+/-)-alfa-lipoico, acido r-(+)-alfa-lipoico, acido s-(-)-alfa-lipoico na forma reduzida ou oxidada ou dos metabolitos assim como sais, esteres, amidas destes para a preparacao de agentes reologicos

Country Status (9)

Country Link
US (1) US5650429A (pt)
EP (2) EP0712626B1 (pt)
JP (1) JP3703545B2 (pt)
AT (2) ATE297201T1 (pt)
CA (2) CA2162306C (pt)
DE (4) DE4439477C2 (pt)
DK (2) DK0712626T3 (pt)
ES (2) ES2242131T3 (pt)
PT (2) PT1374865E (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990153A (en) * 1997-05-05 1999-11-23 Wood; John G. Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury
US6090842A (en) * 1998-03-10 2000-07-18 The Regents Of The University Of California Lipoic acid analogs
DE19818563C2 (de) * 1998-04-25 2003-04-17 Sueddeutsche Kalkstickstoff Verwendung von alpha-Liponsäure zur Verringerung des Appetits und/oder zur Körpergewichtsreduzierung
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US6905707B2 (en) 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
JP4728481B2 (ja) * 1998-10-26 2011-07-20 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク リポ酸誘導体および疾患の治療におけるそれら誘導体の使用
US6573299B1 (en) 1999-09-20 2003-06-03 Advanced Medical Instruments Method and compositions for treatment of the aging eye
DE10027968A1 (de) * 2000-06-08 2001-12-13 Asta Medica Ag Mittel zur Therapie von Demenzen
EP1172110A3 (de) * 2000-07-07 2003-09-17 Basf Aktiengesellschaft Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen
DE10113974B4 (de) * 2001-03-22 2008-05-29 Alzchem Trostberg Gmbh Verwendung von racemischer und enantiomerenreiner Dihydroliponsäure oder deren Derivate zur Körpergewichtsreduzierung und/oder zur Verringerung des Appetits
DE10125883A1 (de) 2001-05-28 2002-12-12 Serumwerk Bernburg Ag Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie
FI20012565A (fi) * 2001-12-21 2003-06-22 Eero Mervaala Immunosuppressiivisessa terapiassa käytettäviä tuotteita
US7030154B2 (en) * 2002-06-07 2006-04-18 Juvenon, Inc. Stability of lipoic acid
US20070196442A1 (en) * 2006-02-10 2007-08-23 Heuer Marvin A Method for improving the oral administration of alpha-lipoic acid
US7282225B1 (en) 2006-09-27 2007-10-16 Occular Technologies, Inc. Composition and methods for improving retinal health
US7943163B2 (en) 2007-08-22 2011-05-17 Response Scientific, Inc. Medical food or nutritional supplement, method of manufacturing same, and method of managing diabetes
US20090054513A1 (en) * 2007-08-22 2009-02-26 Response Scientific, Inc. Method of managing blood glucose levels, insulin levels and/or insulin receptor functionality in individuals with diabetes, polycystic ovarian syndrome and/or alzheimer's disease
CN102008470B (zh) * 2010-05-24 2012-08-29 中国人民解放军第二军医大学 复方制剂及其预防和治疗噪声性听力损伤的用途
RU2451511C1 (ru) * 2010-11-19 2012-05-27 Филя Ивановна Жебровская Способ получения инъекционной формы препарата на основе альфа-липоевой кислоты
CN105622571A (zh) * 2016-03-08 2016-06-01 苏州富士莱医药股份有限公司 一种r-硫辛酸氨基丁三醇盐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58902094D1 (de) * 1988-01-28 1992-10-01 Koeltringer Peter Kombinationspraeparat zur behandlung von nervenzell-und nervenfasererkrankungen und verletzungen.
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
RU1769865C (ru) * 1990-06-13 1992-10-23 Vni Ts Okhrane Zdorovya Materi Cпocoб лeчehия плaцehtaphoй heдoctatoчhoctи
CH683485A5 (fr) * 1990-11-20 1994-03-31 Pasteur Merieux Serums Vacc Solutions de perfusion, de conservation et de reperfusion d'organes.
PT661051E (pt) * 1993-10-11 2006-05-31 Viatris Gmbh Medicamento para o tratamento da hipertensao
DE4420102A1 (de) * 1994-06-09 1995-12-14 Asta Medica Ag Arzneimittelkombinationen aus alpha-Liponsäure und herz-kreislaufaktiven Substanzen

Also Published As

Publication number Publication date
DK0712626T3 (da) 2005-07-04
EP1374865B1 (de) 2005-06-08
PT712626E (pt) 2005-07-29
EP1374865A1 (de) 2004-01-02
CA2162306C (en) 2007-04-10
DE4439477C2 (de) 1999-10-21
CA2521133C (en) 2009-07-14
ATE297201T1 (de) 2005-06-15
DE4439477A1 (de) 1996-05-09
DE4447599A1 (de) 1996-07-04
EP0712626A2 (de) 1996-05-22
DE59511005D1 (de) 2005-07-14
DE4447599C2 (de) 1998-02-26
DK1374865T3 (da) 2005-10-10
ATE290377T1 (de) 2005-03-15
EP0712626B1 (de) 2005-03-09
ES2238676T3 (es) 2005-09-01
US5650429A (en) 1997-07-22
ES2242131T3 (es) 2005-11-01
EP0712626A3 (de) 1997-03-12
CA2162306A1 (en) 1996-05-09
CA2521133A1 (en) 1996-05-09
DE59510993D1 (de) 2005-04-14
JPH08208470A (ja) 1996-08-13
JP3703545B2 (ja) 2005-10-05

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