PT117440A - Processo para a preparação de aminas cíclicas cloroaquilo substituídas - Google Patents

Processo para a preparação de aminas cíclicas cloroaquilo substituídas

Info

Publication number
PT117440A
PT117440A PT117440A PT11744021A PT117440A PT 117440 A PT117440 A PT 117440A PT 117440 A PT117440 A PT 117440A PT 11744021 A PT11744021 A PT 11744021A PT 117440 A PT117440 A PT 117440A
Authority
PT
Portugal
Prior art keywords
chloroachyl
preparation
cyclic amines
substituted
cyclic
Prior art date
Application number
PT117440A
Other languages
English (en)
Other versions
PT117440B (pt
Inventor
Katz Marianna
Sobral Luis
Torres Nuno
Antunes Rafael
Original Assignee
Hovione Farm S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Farm S A filed Critical Hovione Farm S A
Priority to PT117440A priority Critical patent/PT117440B/pt
Priority to CN202180103727.0A priority patent/CN118159526A/zh
Priority to EP21778473.5A priority patent/EP4392411A1/en
Priority to PCT/EP2021/075830 priority patent/WO2023030667A1/en
Publication of PT117440A publication Critical patent/PT117440A/pt
Publication of PT117440B publication Critical patent/PT117440B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A PRESENTE INVENÇÃO ESTÁ RELACIONADA EM GERAL COM UM PROCESSO PARA A PREPARAÇÃO DE AMINAS CÍCLICAS SUBSTITUÍDAS COM DERIVADOS CLOROAQUILO, ESPECIALMENTE, MAS NÃO EXCLUSIVAMENTE, AMINAS CÍCLICAS COM SUBSTITUINTES 1-(2-CLORETILO) E 1-(3-CLOROPROPILO), E EM PARTICULAR, ONDE A AMINA CÍCLICA É PIPERIDINA, OU PIPERAZINA, OU MORFOLINA, OU PIRROLIDINA OU HEXAMETILENOIMINA. EM PARTICULAR, O PROCESSO COMPREENDE FAZER REAGIR UMA AMINA CÍCLICA SECUNDÁRIA COM UM AGENTE ALQUILANTE BIFUNCIONAL, NA PRESENÇA DE UMA BASE ORGÂNICA, EM MODO DE PROCESSO POR LOTES OU EM MODO DE PROCESSO CONTÍNUO, NA AUSÊNCIA DE SOLVENTE, PARA FORMAR A RESPETIVA AMINA CÍCLICA CLOROAQUILADA.
PT117440A 2021-09-03 2021-09-03 Processo para a preparação de aminas cíclicas cloroaquilo substituídas PT117440B (pt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PT117440A PT117440B (pt) 2021-09-03 2021-09-03 Processo para a preparação de aminas cíclicas cloroaquilo substituídas
CN202180103727.0A CN118159526A (zh) 2021-09-03 2021-09-20 制备氯烷基取代的环胺的方法
EP21778473.5A EP4392411A1 (en) 2021-09-03 2021-09-20 Process for the preparation of chloroalkyl substituted cyclic amines
PCT/EP2021/075830 WO2023030667A1 (en) 2021-09-03 2021-09-20 Process for the preparation of chloroalkyl substituted cyclic amines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT117440A PT117440B (pt) 2021-09-03 2021-09-03 Processo para a preparação de aminas cíclicas cloroaquilo substituídas

Publications (2)

Publication Number Publication Date
PT117440A true PT117440A (pt) 2023-03-03
PT117440B PT117440B (pt) 2024-04-26

Family

ID=77951727

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117440A PT117440B (pt) 2021-09-03 2021-09-03 Processo para a preparação de aminas cíclicas cloroaquilo substituídas

Country Status (4)

Country Link
EP (1) EP4392411A1 (pt)
CN (1) CN118159526A (pt)
PT (1) PT117440B (pt)
WO (1) WO2023030667A1 (pt)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202978A (en) 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
MY144753A (en) 2004-04-27 2011-10-31 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
AU2013304102B2 (en) 2012-08-15 2016-09-01 Glaxo Group Limited Chemical process
WO2016044666A1 (en) 2014-09-17 2016-03-24 Epizyme, Inc. Heterocycle substituted amino-pyridine compounds and methods of use thereof
EP3215489B1 (en) 2014-11-03 2019-07-24 OLON S.p.A. Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters
WO2017149518A1 (en) 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
CN107200734B (zh) 2016-03-18 2019-12-24 益方生物科技（上海）有限公司 奎宁环衍生物及其制备方法和用途
PT109740B (pt) 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
CN107935917A (zh) 2017-10-30 2018-04-20 广东莱佛士制药技术有限公司 一种1‑(2‑氯乙基)‑4‑哌啶甲酸酯的合成方法
CN110551079B (zh) * 2019-09-10 2021-04-06 株洲千金药业股份有限公司 一种高纯度盐酸地芬尼多的制备方法

Also Published As

Publication number Publication date
WO2023030667A1 (en) 2023-03-09
EP4392411A1 (en) 2024-07-03
CN118159526A (zh) 2024-06-07
PT117440B (pt) 2024-04-26

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Effective date: 20220520

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Effective date: 20240422