PT1050301E - Medicinal compositions containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol - Google Patents

Medicinal compositions containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol Download PDF

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Publication number
PT1050301E
PT1050301E PT99900351T PT99900351T PT1050301E PT 1050301 E PT1050301 E PT 1050301E PT 99900351 T PT99900351 T PT 99900351T PT 99900351 T PT99900351 T PT 99900351T PT 1050301 E PT1050301 E PT 1050301E
Authority
PT
Portugal
Prior art keywords
octylphenyl
diol
amino
propane
ethyl
Prior art date
Application number
PT99900351T
Other languages
Portuguese (pt)
Inventor
Atsushi Sakai
Rumiko Masuda
Tsuneo Fujii
Tadashi Mishina
Kenji Chiba
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of PT1050301E publication Critical patent/PT1050301E/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Rheumatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a pharmaceutical composition containing 2-amino-2-Ä2-(4-octylphenyl)ethylÜpropane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof, and cyclodextrin as a stabilizer, and where necessary, saccharide, which can be prepared into a liquid agent, and which is useful for the suppression of rejection in organ or bone marrow transplantation, immunosuppressive sustention therapy therefor or the treatment of autoimmune diseases.
PT99900351T 1998-01-19 1999-01-19 Medicinal compositions containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol PT1050301E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10008045A JPH11209277A (en) 1998-01-19 1998-01-19 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
PT1050301E true PT1050301E (en) 2009-06-16

Family

ID=11682381

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99900351T PT1050301E (en) 1998-01-19 1999-01-19 Medicinal compositions containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol

Country Status (15)

Country Link
EP (1) EP1050301B1 (en)
JP (2) JPH11209277A (en)
KR (1) KR100546450B1 (en)
CN (1) CN1191062C (en)
AT (1) ATE426402T1 (en)
AU (1) AU1891199A (en)
BR (1) BR9907099A (en)
CA (1) CA2319217C (en)
DE (1) DE69940633D1 (en)
ES (1) ES2323199T3 (en)
IL (1) IL137362A (en)
NZ (1) NZ506408A (en)
PT (1) PT1050301E (en)
RU (1) RU2204387C2 (en)
WO (1) WO1999036065A1 (en)

Families Citing this family (19)

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JP4627356B2 (en) 1999-06-30 2011-02-09 松森　　昭 Drugs for preventing or treating viral myocarditis
WO2002018395A1 (en) 2000-08-31 2002-03-07 Merck & Co., Inc. Phosphate derivatives as immunoregulatory agents
JP2007217438A (en) * 2001-07-17 2007-08-30 Shionogi & Co Ltd Medical preparation for injection
TWI232102B (en) * 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
GB0125443D0 (en) 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
KR100836547B1 (en) 2002-01-11 2008-06-10 상꾜 가부시키가이샤 Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these
US20040014662A1 (en) 2002-05-08 2004-01-22 Per Lindquist Modulation of neural stem cells and neural progenitor cells
DE122011100047I1 (en) * 2003-04-08 2011-12-15 Mitsubishi Tanabe Pharma Corp Solid pharmaceutical dosage forms containing a S1P receptor agonist and a sugar alcohol.
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
EP1484057A1 (en) * 2003-06-06 2004-12-08 Aventis Pharma Deutschland GmbH Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain
US7524887B2 (en) 2003-06-06 2009-04-28 Sanofi-Aventis Deutschland Gmbh 2-amino-1,3-propanediol compounds for the treatment of acute pain
BRPI0507944A (en) 2004-02-24 2007-07-24 Sankyo Co pharmaceutical composition
RU2402324C2 (en) * 2004-07-30 2010-10-27 Новартис Аг 2-amino-1,3-propanediol compositions
SI2278960T2 (en) * 2008-03-17 2020-02-28 Actelion Pharmaceuticals Ltd. Dosing regimen for a selective sip1 receptor agonist
US8766005B2 (en) * 2009-07-24 2014-07-01 Ratiopharm Gmbh Process for producing fingolimod salts
AR085749A1 (en) * 2011-04-01 2013-10-23 Novartis Ag FORMULATIONS
DE102012101680A1 (en) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
KR20200127222A (en) * 2018-03-01 2020-11-10 이시하라 산교 가부시끼가이샤 Pharmaceutical composition with excellent storage stability

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JPS51133960A (en) * 1975-05-16 1976-11-20 Kao Corp Defoaming method
JPS5718607A (en) * 1980-07-07 1982-01-30 Kaken Pharmaceut Co Ltd Injection preparation
JPS58148816A (en) * 1982-02-27 1983-09-05 Nippon Zenyaku Kogyo Kk Low irritant thiamulin injection
JPS63253022A (en) * 1987-04-08 1988-10-20 Nitto Electric Ind Co Ltd Baclofen pharmaceutical for external use
IE62095B1 (en) * 1988-03-29 1994-12-14 Univ Florida Pharmaceutical formulations for parenteral use
EP0335545B2 (en) * 1988-03-29 1998-09-23 University Of Florida Pharmaceutical formulations for parenteral use
JP3054776B2 (en) * 1990-04-13 2000-06-19 丸善製薬株式会社 Method for controlling sweetness of glycyrrhizin
TW200402B (en) * 1990-08-13 1993-02-21 Senju Pharma Co
JPH0616547A (en) * 1992-07-01 1994-01-25 Wakamoto Pharmaceut Co Ltd Antiphlogistic ophthalmic solution
KR0155015B1 (en) * 1992-10-21 1998-12-01 고우야 마사시 2-amino-1,3-propanediol compound and immunosuppressant
JP2879395B2 (en) * 1992-10-26 1999-04-05 富士写真フイルム株式会社 Anticancer composition containing rhodacyanine compound and cyclodextrin
JPH07228532A (en) * 1993-04-22 1995-08-29 Senju Pharmaceut Co Ltd Water-soluble solution, method for improving solubility of its active ingredient and stabilization thereof
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Also Published As

Publication number Publication date
DE69940633D1 (en) 2009-05-07
JP4434486B2 (en) 2010-03-17
EP1050301A4 (en) 2004-11-17
RU2204387C2 (en) 2003-05-20
ATE426402T1 (en) 2009-04-15
IL137362A0 (en) 2001-07-24
WO1999036065A1 (en) 1999-07-22
CA2319217C (en) 2008-03-25
KR20010034240A (en) 2001-04-25
ES2323199T3 (en) 2009-07-08
IL137362A (en) 2003-06-24
CN1294511A (en) 2001-05-09
EP1050301B1 (en) 2009-03-25
AU1891199A (en) 1999-08-02
KR100546450B1 (en) 2006-01-26
JPH11209277A (en) 1999-08-03
NZ506408A (en) 2002-09-27
EP1050301A1 (en) 2000-11-08
CN1191062C (en) 2005-03-02
CA2319217A1 (en) 1999-07-22
BR9907099A (en) 2001-09-04

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