PL9380B1 - Method of inhibiting glycolysis of living cells. - Google Patents
Method of inhibiting glycolysis of living cells. Download PDFInfo
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- PL9380B1 PL9380B1 PL9380A PL938027A PL9380B1 PL 9380 B1 PL9380 B1 PL 9380B1 PL 9380 A PL9380 A PL 9380A PL 938027 A PL938027 A PL 938027A PL 9380 B1 PL9380 B1 PL 9380B1
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- living cells
- inhibiting glycolysis
- glycolysis
- inhibiting
- cells
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Wiadomo, ze fluorek sodowy moze za¬ hamowac lub ograniczyc znacznie nawet przy nieznacznem stezeniu fermentacje drozdzy.Spostrzezono nadspodziewanie, ze rów¬ niez i organiczne zwiazki fluorowe, jako to kwas fluorooctowy, fluorobenzoesowy, fluorobenzenosulfonowy i t. d,, pomimo, ze zawieraja fluor w postaci nie jonizujacej, dzialaja podobnie hamujaco. W przeci¬ wienstwie do fluorku sodowego, organicz^ ne zwiazki fluorowe sa, z punktu widzenia farmakologicznego, znacznie mniej truja¬ ce, co nalezy przypisac zespolonemu zwia¬ zaniu fluoru, I tak np, kwas fluorobenzo¬ esowy mozna stosowac do otrzymywania piwa trwalego.Nietylko komórki drozdzowe, lecz rów¬ niez i inne glikolizujace komórki, jako to bakterje anaerobowe, (Tumorzellen) i L d. pod dzialaniem zwiazków rzeczonych prze¬ rywaja swa glikolize; nie wplywa to jed¬ nak szkodliwie na oddychanie komórek, PL PLIt is known that sodium fluoride can inhibit or significantly reduce yeast fermentation even at low concentrations. It has been surprisingly found that also organic fluorine compounds, such as fluoroacetic acid, fluorobenzoic acid, fluorobenzene sulfonic acid, etc., despite the fact that they contain fluorine in a non-ionizing form, they have a similar inhibitory effect. Contrary to sodium fluoride, organic fluorine compounds are, from a pharmacological point of view, much less poisonous, which is attributable to the complex binding of fluoride. For example, fluorobenzoic acid can be used in the preparation of stable beer. Not only yeast cells, but also other glycosylating cells, such as anaerobic bacteria (Tumorzellen) and L d. Under the action of said compounds, break their glycolysis; however, it does not adversely affect cell respiration, PL PL
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| Publication Number | Publication Date |
|---|---|
| PL9380B1 true PL9380B1 (en) | 1928-10-31 |
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