PL8237B1 - A method of obtaining revealing, therapeutically valuable solutions containing organically combined phosphorus and gold. - Google Patents
A method of obtaining revealing, therapeutically valuable solutions containing organically combined phosphorus and gold. Download PDFInfo
- Publication number
- PL8237B1 PL8237B1 PL8237A PL823726A PL8237B1 PL 8237 B1 PL8237 B1 PL 8237B1 PL 8237 A PL8237 A PL 8237A PL 823726 A PL823726 A PL 823726A PL 8237 B1 PL8237 B1 PL 8237B1
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- PL
- Poland
- Prior art keywords
- gold
- solutions containing
- revealing
- obtaining
- solutions
- Prior art date
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 title claims description 4
- 239000010931 gold Substances 0.000 title claims description 4
- 229910052737 gold Inorganic materials 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title claims 2
- 239000011574 phosphorus Substances 0.000 title claims 2
- 229910052698 phosphorus Inorganic materials 0.000 title claims 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 3
- 239000004133 Sodium thiosulphate Substances 0.000 claims description 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 8
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical class OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940083577 gold sodium thiosulfate Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000002367 phosphate rock Substances 0.000 description 1
- 150000003018 phosphorus compounds Chemical class 0.000 description 1
- -1 sodium p-diethylaminotolylphosphinite Chemical compound 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- KZNBHWLDPGWJMM-UHFFFAOYSA-J trisodium;dioxido-oxo-sulfanylidene-$l^{6}-sulfane;gold(1+);dihydrate Chemical compound O.O.[Na+].[Na+].[Na+].[Au+].[O-]S([O-])(=O)=S.[O-]S([O-])(=O)=S KZNBHWLDPGWJMM-UHFFFAOYSA-J 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Description
Opisane w patencie niemieckim Nr 397813 sale kwasów dwualkyloaminoary-- lofcisfinawycih rozkladaja sie przy nagrze¬ waniu ich roztworów wodnych, odsizoze- piajac odnosne zasady aromatyczne.Obecnie istwier dz ono nadspodziewanie, iz mozna otrzymac zupelnie trwale i daja¬ ce sie wyjalawiac roztwory, skoro na roz¬ twory rzeczonych soli kwasów klwualky- 1 oaminoary lof osf inawych dzialac roztwo¬ rami zloitowemi, otrzymywanemi zapomoca zmieszania i rozpuszczenia sprezonego tio¬ siarczanu zlotowo - isiodowego i (czystego) tiosiarczanu sodowego albo zapomoca zmieszania roztworów tychze. Prawdopo¬ dobnie chodzi o tworzenie sie zespolonych produktów przylaczenia.W tein sposób otrzymuje isle roztwory o wysokiej wartosci leczniczej, które moz¬ na wstrzykiwac nie wywolujac draznienia i które i przy doswiadczeniach, dokonanych nad zwierzetami', jak i przy próbach (kli¬ nicznych anie wykazaly szkodliwego pobocz¬ nego dzialania nawet przy zastopowaniu wiekszych ilosci, przeciwnie 1— dzialaly w procesach tuberkulicznych pod wzigle- dem leczniczym w wysokim stopniu do¬ datnio.Powyzsze wyniki dodatnie nalezy przy¬ pisac czesciowo obecnosci zlota, czesciowozas, bezwatpienia — obecnosci iosforu, gdyz, jak wykazaly próby kliniczne, fosfor yt postaci kwasu dwualkyloaminoarylofo- * * sfinawegól jesf* lakomi tym srodkiem po¬ mocniczym przy leczeniu chorób gruzlicz- nych i jak stwierdzono na drodze farmako¬ logicznej i klinicznej, wlasmosci antysep- tyczne nalezy przypisac zwiazkom fosforo¬ wym, co przy leczeniu zlotem, które czesto stawia znaczne wymagania muskulom ser¬ cowym, posiada wielkie znaczenie.Przyklad, 100 g tiosiarczanu zlotowo- sodowego i 25 g czystego tiosiarczanu so¬ dowego rozpuszcza sie jednoczesnie w 5 1 wody, dodaje roztwór, zawierajacy 50 g p - dwuetyloaminotolylofosfininu sodowego w 5 1 wody, i wyjalawia w sposób zwykly przeplywajaca para wodna; roztwór ' nie przestaje byc zupelnie przezroczysty.Ilosc mieszanych skladników, moze sie wahac w granicach (szerokich. Równiez za¬ leznie od wyniku, jaki chce sie otrzymac miesza isie i wyjalawia, badz roztwory, badz substancje w isitanie stalym, które na¬ stepnie sie rozpuszcza i wyjalawia. PLThe chambers of dialkylaminoarines described in German Patent No. 397813 decompose when their aqueous solutions are heated, de-icing the relevant aromatic bases. At present, it is surprising that it is possible to obtain completely stable and exposable solutions, Solutions of the said salts of klvualky-1 phosphorous acids are treated with gold solutions obtained by mixing and dissolving compressed gold sodium thiosulfate and (pure) sodium thiosulfate or by mixing the solutions of these. It is likely the formation of complex attachment products. In this way, it obtains very good solutions of high therapeutic value, which can be injected without causing irritation, and which, both in animal experiments and in trials (clinical trials). showed deleterious side effects even with the suppression of larger amounts, on the contrary, they worked highly positively in tuberculic processes under therapeutic treatment. Clinical trials have shown that phosphorite in the dialkylamino arylphosphate form is particularly suitable as an adjuvant in the treatment of tuberculosis diseases and, pharmacologically and clinically, antiseptic properties have been found to be attributed to phosphorus compounds. which in the treatment of gold, which often places considerable demands on the heart muscles, has of great importance. For example, 100 g of sodium sodium thiosulphate and 25 g of pure sodium thiosulphate are simultaneously dissolved in 5 l of water, add a solution containing 50 g of sodium p-diethylaminotolylphosphinite in 5 l of water, and expel in the usual way by flowing steam; the solution 'does not cease to be completely transparent. The number of mixed ingredients can vary within limits (wide. Also depending on the result you want to get, mix and explain, or solutions, or substances in solids that will melt) dissolves and exposes PL
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL8237B1 true PL8237B1 (en) | 1928-01-31 |
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