PL450465A1 - Sposób wytwarzania ryboflawiny - Google Patents

Sposób wytwarzania ryboflawiny

Info

Publication number
PL450465A1
PL450465A1 PL450465A PL45046520A PL450465A1 PL 450465 A1 PL450465 A1 PL 450465A1 PL 450465 A PL450465 A PL 450465A PL 45046520 A PL45046520 A PL 45046520A PL 450465 A1 PL450465 A1 PL 450465A1
Authority
PL
Poland
Prior art keywords
riboflavin
culture
period
added
temperature
Prior art date
Application number
PL450465A
Other languages
English (en)
Inventor
Andriy Sybirny
Justyna Ruchała
Daria Fedorovych
Alicja Wojtuń
Agata Znamirowska
Kostyantyn Dmytruk
Andrij Tsyrulnyk
Original Assignee
Uniwersytet Rzeszowski
Podkarpackie Centrum Innowacji Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Rzeszowski, Podkarpackie Centrum Innowacji Spółka Z Ograniczoną Odpowiedzialnością filed Critical Uniwersytet Rzeszowski
Priority to PL450465A priority Critical patent/PL450465A1/pl
Publication of PL450465A1 publication Critical patent/PL450465A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/72—Candida

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Sposób wytwarzania ryboflawiny charakteryzuje się tym, że serwatkę o minimalnej zawartości laktozy na poziomie 4,6% sterylizuje się w temperaturze od 118°C do 123°C przez okres od 18 do 25 minut, a następnie filtruje się oddzielając wytrącone białka, po czym dodaje się związek będący źródłem azotu w ilości od 1 do 4 g/l; do tak przygotowanej serwatki dodaje się komórki Candida famata w fazie wzrostu logarytmicznego wypłukane z podłoża syntetycznego w ilości 1 mg/l i prowadzi się hodowlę bez dostępu światła w temperaturze od 28°C do 30°C, napowietrzając ją i mieszając przez okres od 120 do 240 h, przy czym pH hodowli utrzymuje się na poziomie 4,5 do 5,5, dodając w razie potrzeby 10%-owy roztwór NaOH bądź 10%- owy roztwór H2SO4, a w efekcie uzyskuje się od 0,95 do 1,2 g/l ryboflawiny.
PL450465A 2020-09-15 2020-09-15 Sposób wytwarzania ryboflawiny PL450465A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL450465A PL450465A1 (pl) 2020-09-15 2020-09-15 Sposób wytwarzania ryboflawiny

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL450465A PL450465A1 (pl) 2020-09-15 2020-09-15 Sposób wytwarzania ryboflawiny

Publications (1)

Publication Number Publication Date
PL450465A1 true PL450465A1 (pl) 2025-07-21

Family

ID=96430869

Family Applications (1)

Application Number Title Priority Date Filing Date
PL450465A PL450465A1 (pl) 2020-09-15 2020-09-15 Sposób wytwarzania ryboflawiny

Country Status (1)

Country Link
PL (1) PL450465A1 (pl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001060A1 (en) * 1990-07-13 1992-01-23 Zeagen, Inc. A fermentation process for riboflavin-producing organisms
US5164303A (en) * 1985-12-20 1992-11-17 Zeagen, Inc. Method for producing riboflavin with Candida famata
US5231007A (en) * 1988-09-29 1993-07-27 Zeagen, Inc. Efficient riboflavin production with yeast

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164303A (en) * 1985-12-20 1992-11-17 Zeagen, Inc. Method for producing riboflavin with Candida famata
US5231007A (en) * 1988-09-29 1993-07-27 Zeagen, Inc. Efficient riboflavin production with yeast
WO1992001060A1 (en) * 1990-07-13 1992-01-23 Zeagen, Inc. A fermentation process for riboflavin-producing organisms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOSTYANTYN V. I INN.:: "Metabolic Engineering 13 (2011) 82–88.", METABOLIC ENGINEERING AND CLASSIC SELECTION OF THE YEAST CANDIDA FAMATA (CANDIDA FLARERI) FOR CONSTRUCTION OF STRAINS WITH ENHANCED RIBOFLAVIN PRODUCTION, *

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