PL449569A1 - Implant kostny na bazie kurdlanu oraz czułego na zmiany pH kompleksu zeolitowo-chitozanowo-bisfosfonianowego oraz sposób jego wytwarzania - Google Patents
Implant kostny na bazie kurdlanu oraz czułego na zmiany pH kompleksu zeolitowo-chitozanowo-bisfosfonianowego oraz sposób jego wytwarzaniaInfo
- Publication number
- PL449569A1 PL449569A1 PL449569A PL44956924A PL449569A1 PL 449569 A1 PL449569 A1 PL 449569A1 PL 449569 A PL449569 A PL 449569A PL 44956924 A PL44956924 A PL 44956924A PL 449569 A1 PL449569 A1 PL 449569A1
- Authority
- PL
- Poland
- Prior art keywords
- chitosan
- nanopowder
- powder
- curdlan
- zeolite
- Prior art date
Links
- 229920002558 Curdlan Polymers 0.000 title abstract 4
- 239000001879 Curdlan Substances 0.000 title abstract 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 title abstract 4
- 229940078035 curdlan Drugs 0.000 title abstract 4
- 235000019316 curdlan Nutrition 0.000 title abstract 4
- 210000000988 bone and bone Anatomy 0.000 title abstract 3
- 239000007943 implant Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940122361 Bisphosphonate Drugs 0.000 title 1
- 239000011858 nanopowder Substances 0.000 abstract 6
- 239000000843 powder Substances 0.000 abstract 6
- 229910021536 Zeolite Inorganic materials 0.000 abstract 4
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 4
- 239000010457 zeolite Substances 0.000 abstract 4
- 239000003462 bioceramic Substances 0.000 abstract 3
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 3
- 239000001506 calcium phosphate Substances 0.000 abstract 3
- 235000011010 calcium phosphates Nutrition 0.000 abstract 3
- 239000008187 granular material Substances 0.000 abstract 3
- 229940089617 risedronate Drugs 0.000 abstract 3
- 235000019731 tricalcium phosphate Nutrition 0.000 abstract 3
- 229920001661 Chitosan Polymers 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 239000008367 deionised water Substances 0.000 abstract 2
- 229910021641 deionized water Inorganic materials 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 208000001164 Osteoporotic Fractures Diseases 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000002051 biphasic effect Effects 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest implant kostny według wynalazku, który charakteryzuje się tym, że stanowi go kurdlan, bioceramika fosforanowo-wapniowa w postaci granul, kompleks Na-X-chitozan-ryzedronian w postaci proszku lub nanoproszku oraz zeolit Na-X sfunkcjonalizowany za pomocą chitozanu (Na-X-chitozan) w postaci proszku lub nanoproszku, rozprowadzone w wodzie dejonizowanej, przy czym proporcje wagowe stałych komponentów wynoszą odpowiednio 8% (w/v) kurdlanu, 40% (w/v) bioceramiki fosforanowo-wapniowej w postaci granul, 10% (w/v) kompleksu Na-X-chitozan-ryzedronian w postaci proszku lub nanoproszku oraz 10% (w/v) zeolitu Na-X-chitozan w postaci proszku lub nanoproszku w odniesieniu do wody dejonizowanej. Zgłoszenie obejmuje także sposób wytwarzania implantu kostnego do leczenia złamań osteoporotycznych według wynalazku, który polega na tym, że bioceramikę fosforanowo-wapniową (hydroksyapatyt (HA), fosforany trójwapniowe (TCP), modyfikowany HA, materiały dwufazowe (BCP) złożone z HA i TCP) w postaci granul oraz mieszankę zeolitową zawierającą kompleks Na-X-chitozan-ryzedronian w postaci proszku lub nanoproszku i zeolit Na-X sfunkcjonalizowany za pomocą chitozanu (Na-X-chitozan) w postaci proszku lub nanoproszku rozprowadza się w wodnym roztworze kurdlanu. Otrzymany rodzaj pasty poddaje się działaniu wysokiej temperatury, a następnie schłodzeniu do temperatury pokojowej oraz suszeniu na powietrzu.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL449569A PL449569A1 (pl) | 2024-08-22 | 2024-08-22 | Implant kostny na bazie kurdlanu oraz czułego na zmiany pH kompleksu zeolitowo-chitozanowo-bisfosfonianowego oraz sposób jego wytwarzania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL449569A PL449569A1 (pl) | 2024-08-22 | 2024-08-22 | Implant kostny na bazie kurdlanu oraz czułego na zmiany pH kompleksu zeolitowo-chitozanowo-bisfosfonianowego oraz sposób jego wytwarzania |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL449569A1 true PL449569A1 (pl) | 2025-04-22 |
Family
ID=95451027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL449569A PL449569A1 (pl) | 2024-08-22 | 2024-08-22 | Implant kostny na bazie kurdlanu oraz czułego na zmiany pH kompleksu zeolitowo-chitozanowo-bisfosfonianowego oraz sposób jego wytwarzania |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL449569A1 (pl) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL235822B1 (pl) * | 2018-08-24 | 2020-11-02 | Univ Medyczny W Lublinie | Kriożelowe rusztowanie kostne na bazie chitozanu i bioceramiki fosforoanowo-wapniowej oraz sposób jego wytwarzania |
| PL242079B1 (pl) * | 2020-10-29 | 2023-01-16 | Politechnika Poznańska | Materiał tytanowy z przeznaczeniem na implant i sposób jego wytwarzania |
| PL442450A1 (pl) * | 2022-10-05 | 2024-04-08 | Uniwersytet Medyczny W Lublinie | Nanokompozytowe rusztowanie kostne na bazie matrycy kurdlanowo-chitozanowej i hydroksyapatytu oraz sposób jego wytwarzania |
-
2024
- 2024-08-22 PL PL449569A patent/PL449569A1/pl unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL235822B1 (pl) * | 2018-08-24 | 2020-11-02 | Univ Medyczny W Lublinie | Kriożelowe rusztowanie kostne na bazie chitozanu i bioceramiki fosforoanowo-wapniowej oraz sposób jego wytwarzania |
| PL242079B1 (pl) * | 2020-10-29 | 2023-01-16 | Politechnika Poznańska | Materiał tytanowy z przeznaczeniem na implant i sposób jego wytwarzania |
| PL442450A1 (pl) * | 2022-10-05 | 2024-04-08 | Uniwersytet Medyczny W Lublinie | Nanokompozytowe rusztowanie kostne na bazie matrycy kurdlanowo-chitozanowej i hydroksyapatytu oraz sposób jego wytwarzania |
Non-Patent Citations (3)
| Title |
|---|
| Frontiersin; Yue Li et al. "Zeolites: A series of promising biomaterials in bone tissue engineering" Front. Bioeng. Biotechnol., 17 November 2022, Sec. Biomaterials, Volume 10 - 2022 | https://doi.org/10.3389/fbioe.2022.1066552 * |
| ScienceDirect; M. Sandomierski et al."Chitosan - zeolite scaffold as a potential biomaterial in the controlled release of drugs for osteoporosis", International Journal of Biological Macromolecules, Volume 223, Part A, 31 December 2022, Pages 812-820, https://doi.org/10.1016/j.ijpharm.2020.119117 * |
| tandfonline.com; M. Saheban et al."Effect of zeolite on the corrosion behavior, biocompatibility and antibacterial activity of porous magnesium/zeolite composite scaffolds", Materials Technology Advanced Performance Materials, Volume 34, 2019 - Issue 5, https://doi.org/10.1080/10667857.2018.1549803 * |
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