PL439109A1 - Method of preparing 4'-hydroxyflavone - Google Patents

Method of preparing 4'-hydroxyflavone

Info

Publication number
PL439109A1
PL439109A1 PL439109A PL43910921A PL439109A1 PL 439109 A1 PL439109 A1 PL 439109A1 PL 439109 A PL439109 A PL 439109A PL 43910921 A PL43910921 A PL 43910921A PL 439109 A1 PL439109 A1 PL 439109A1
Authority
PL
Poland
Prior art keywords
hydroxyflavone
hours
formula
organic solvent
water
Prior art date
Application number
PL439109A
Other languages
Polish (pl)
Other versions
PL244831B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439109A priority Critical patent/PL244831B1/en
Publication of PL439109A1 publication Critical patent/PL439109A1/en
Publication of PL244831B1 publication Critical patent/PL244831B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 4'-hydroksyflawonu polegający na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metyloflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą  i oczyszcza chromatograficznie, przy czym 4'-hydroksyflawon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w czwartym paśmie od linii startu.The subject matter of the application is a method of producing 4'-hydroxyflavone in which the strain Isaria fumosorosea KCH J2 is introduced into the medium suitable for filamentous fungi, and then, after at least 72 hours, the substrate is introduced into the culture, which is 4'-methylflavone of formula 1 , dissolved in a water-miscible organic solvent, transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, after which the product is extracted with a water-miscible organic solvent and purified by chromatography, with 4' -hydroxyflavone of the formula 2 is in the fraction of intermediate polarity, in the fourth band from the starting line.

PL439109A 2021-10-01 2021-10-01 Method of preparing 4'-hydroxyflavone PL244831B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439109A PL244831B1 (en) 2021-10-01 2021-10-01 Method of preparing 4'-hydroxyflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439109A PL244831B1 (en) 2021-10-01 2021-10-01 Method of preparing 4'-hydroxyflavone

Publications (2)

Publication Number Publication Date
PL439109A1 true PL439109A1 (en) 2023-04-03
PL244831B1 PL244831B1 (en) 2024-03-11

Family

ID=85784021

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439109A PL244831B1 (en) 2021-10-01 2021-10-01 Method of preparing 4'-hydroxyflavone

Country Status (1)

Country Link
PL (1) PL244831B1 (en)

Also Published As

Publication number Publication date
PL244831B1 (en) 2024-03-11

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