PL438644A1 - 2'-Methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 2'-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone - Google Patents

2'-Methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 2'-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

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Publication number
PL438644A1
PL438644A1 PL438644A PL43864421A PL438644A1 PL 438644 A1 PL438644 A1 PL 438644A1 PL 438644 A PL438644 A PL 438644A PL 43864421 A PL43864421 A PL 43864421A PL 438644 A1 PL438644 A1 PL 438644A1
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PL
Poland
Prior art keywords
methylglucopyranosyl
flavanone
methyl
formula
hours
Prior art date
Application number
PL438644A
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Polish (pl)
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL438644A priority Critical patent/PL438644A1/en
Publication of PL438644A1 publication Critical patent/PL438644A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest 2'-metylo-3'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2 oraz sposób wytwarzania 2'-metylo-3'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanonu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 2'-metyloflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 2'-metylo-3'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w trzecim paśmie od linii startu.The subject of the application is 2'-methyl-3'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone of the formula 2 and a method for producing 2'-methyl-3'-O-β-D-(4" -O-methylglucopyranosyl)-flavanone characterized in that the strain Isaria fumosorosea KCH J2 is introduced into the substrate suitable for filamentous fungi, then after at least 72 hours the substrate is introduced into the culture, which is 2'-methylflavanone of the formula 1, dissolved in a water-miscible organic solvent, the transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, 2'-methyl -3'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone of formula 2 is found in the fraction of intermediate polarity, in the third band from the starting line.

PL438644A 2021-07-30 2021-07-30 2'-Methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 2'-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone PL438644A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL438644A PL438644A1 (en) 2021-07-30 2021-07-30 2'-Methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 2'-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL438644A PL438644A1 (en) 2021-07-30 2021-07-30 2'-Methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 2'-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Publications (1)

Publication Number Publication Date
PL438644A1 true PL438644A1 (en) 2023-02-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL438644A PL438644A1 (en) 2021-07-30 2021-07-30 2'-Methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for preparing 2'-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Country Status (1)

Country Link
PL (1) PL438644A1 (en)

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