PL436246A1 - 7-Methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone - Google Patents

7-Methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

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Publication number
PL436246A1
PL436246A1 PL436246A PL43624620A PL436246A1 PL 436246 A1 PL436246 A1 PL 436246A1 PL 436246 A PL436246 A PL 436246A PL 43624620 A PL43624620 A PL 43624620A PL 436246 A1 PL436246 A1 PL 436246A1
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PL
Poland
Prior art keywords
methylglucopyranosyl
flavanone
methoxy
formula
hours
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Application number
PL436246A
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Polish (pl)
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PL244214B1 (en
Inventor
Monika Dymarska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
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Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL436246A priority Critical patent/PL244214B1/en
Publication of PL436246A1 publication Critical patent/PL436246A1/en
Publication of PL244214B1 publication Critical patent/PL244214B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest 7-metoksy-3'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2. Zgłoszenie zawiera też sposób wytwarzania 7-metoksy-3'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanonu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych, zawierającego sacharozę, wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 7-metoksyflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, dalej transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 7-metoksy-3'-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2 znajduje się we frakcji o wyższej polarności, w trzecim paśmie od linii startu.The subject of the application is 7-methoxy-3'-O-β-D- (4 "-O-methylglucopyranosyl) -flavanone of the formula 2. The application also includes a process for the preparation of 7-methoxy-3'-O-β-D- (4 "-O-methylglucopyranosyl) -flavanone characterized in that the Isaria fumosorosea KCH J2 strain is introduced into a substrate suitable for filamentous fungi containing sucrose, then after at least 72 hours the substrate is introduced into the culture, which is 7-methoxyflavanone with of formula 1, dissolved in a water-miscible organic solvent, the transformation is further carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, then the product is extracted with a water-immiscible organic solvent and purified by chromatography with wherein the 7-methoxy-3'-O-β-D- (4 "-O-methylglucopyranosyl) -flavanone of formula II is in the higher polarity fraction in the third band from the starting line.

PL436246A 2020-12-06 2020-12-06 7-Methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone PL244214B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL436246A PL244214B1 (en) 2020-12-06 2020-12-06 7-Methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL436246A PL244214B1 (en) 2020-12-06 2020-12-06 7-Methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Publications (2)

Publication Number Publication Date
PL436246A1 true PL436246A1 (en) 2022-06-13
PL244214B1 PL244214B1 (en) 2023-12-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL436246A PL244214B1 (en) 2020-12-06 2020-12-06 7-Methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method of preparing 7-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

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Also Published As

Publication number Publication date
PL244214B1 (en) 2023-12-18

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