PL438266A1 - Method for producing a polyacrylate copolymer constituting the adhesive layer of a transdermal patch and a method for producing a transdermal patch - Google Patents

Method for producing a polyacrylate copolymer constituting the adhesive layer of a transdermal patch and a method for producing a transdermal patch

Info

Publication number
PL438266A1
PL438266A1 PL438266A PL43826621A PL438266A1 PL 438266 A1 PL438266 A1 PL 438266A1 PL 438266 A PL438266 A PL 438266A PL 43826621 A PL43826621 A PL 43826621A PL 438266 A1 PL438266 A1 PL 438266A1
Authority
PL
Poland
Prior art keywords
producing
transdermal patch
weight
adhesive layer
polyacrylate copolymer
Prior art date
Application number
PL438266A
Other languages
Polish (pl)
Inventor
Paula Ossowicz-Rupniewska
Paulina Bednarczyk
Małgorzata Nowak
Original Assignee
Zachodniopomorski Uniwersytet Technologiczny W Szczecinie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zachodniopomorski Uniwersytet Technologiczny W Szczecinie filed Critical Zachodniopomorski Uniwersytet Technologiczny W Szczecinie
Priority to PL438266A priority Critical patent/PL438266A1/en
Publication of PL438266A1 publication Critical patent/PL438266A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/04—Polymerisation in solution
    • C08F2/06—Organic solvent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09J133/08—Homopolymers or copolymers of acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09J133/10—Homopolymers or copolymers of methacrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J7/00—Adhesives in the form of films or foils
    • C09J7/30—Adhesives in the form of films or foils characterised by the adhesive composition
    • C09J7/38—Pressure-sensitive adhesives [PSA]
    • C09J7/381—Pressure-sensitive adhesives [PSA] based on macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C09J7/385—Acrylic polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Polymerisation Methods In General (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania kopolimeru poliakrylanowego stanowiącego warstwę klejową plastra transdermalnego, polegający na polimeryzacji rozpuszczalnikowej (np. octan etylu) monomerów akrylanowych w obecności inicjatora i fotoinicjatora. Sposób charakteryzuje się tym, że polimeryzacji poddaje się 60 ÷ 90% wagowych estrów alkilowych kwasu akrylowego o długości łańcucha węglowego powyżej 3 atomów, 1 ÷ 5% wagowych kwasu akrylowego, 1 ÷ 30% wagowych akrylowanego biosurowca w postaci metakrylanu izobornylu i 0,01 ÷ 5% wagowych nienasyconego fotoinicjatora, przy czym udział wagowy wszystkich komponentów mieszaniny reakcyjnego wynosi 100%, a jako inicjator polimeryzacji wolnorodnikowej stosuje się 2,2'-azobisizobutyronitrylu. Przedmiotem zgłoszenia jest także sposób wytwarzania plastra transdermalnego, polegający na naniesieniu na nośnik warstwy klejowej i zabezpieczeniu folią zabezpieczającą. Sposób charakteryzuje się tym, że kopolimer poliakrylanowy z wbudowanym fotoinicjatorem, otrzymany sposobem opisanym powyżej powleka się na nośniku, suszy się w podwyższonej temperaturze od 100 - 140°C, a następnie sieciuje się naświetlając promieniami UV w zakresie 200 — 400 nm.The subject of the application is a method of producing a polyacrylate copolymer constituting the adhesive layer of a transdermal patch, consisting in solvent polymerization (e.g. ethyl acetate) of acrylate monomers in the presence of an initiator and a photoinitiator. The method is characterized in that 60 ÷ 90% by weight of acrylic acid alkyl esters with a carbon chain length of more than 3 atoms, 1 ÷ 5% by weight of acrylic acid, 1 ÷ 30% by weight of acrylated bio-raw material in the form of isobornyl methacrylate and 0.01 ÷ 5% by weight of unsaturated photoinitiator, where the weight share of all components of the reaction mixture is 100%, and 2,2'-azobisisobutyronitrile is used as the initiator of the free radical polymerization. The subject of the application is also a method of producing a transdermal patch, consisting in applying an adhesive layer to a carrier and securing it with a protective foil. The method is characterized in that the polyacrylate copolymer with built-in photoinitiator, obtained by the method described above, is coated on a support, dried at an elevated temperature of 100 - 140°C, and then crosslinked by irradiation with UV rays in the range of 200 - 400 nm.

PL438266A 2021-06-25 2021-06-25 Method for producing a polyacrylate copolymer constituting the adhesive layer of a transdermal patch and a method for producing a transdermal patch PL438266A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL438266A PL438266A1 (en) 2021-06-25 2021-06-25 Method for producing a polyacrylate copolymer constituting the adhesive layer of a transdermal patch and a method for producing a transdermal patch

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL438266A PL438266A1 (en) 2021-06-25 2021-06-25 Method for producing a polyacrylate copolymer constituting the adhesive layer of a transdermal patch and a method for producing a transdermal patch

Publications (1)

Publication Number Publication Date
PL438266A1 true PL438266A1 (en) 2022-12-27

Family

ID=84603211

Family Applications (1)

Application Number Title Priority Date Filing Date
PL438266A PL438266A1 (en) 2021-06-25 2021-06-25 Method for producing a polyacrylate copolymer constituting the adhesive layer of a transdermal patch and a method for producing a transdermal patch

Country Status (1)

Country Link
PL (1) PL438266A1 (en)

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